Zobrazeno 1 - 10
of 11
pro vyhledávání: '"LeMoyne Mueller"'
Publikováno v:
Blood Cells, Molecules, and Diseases. 39:307-315
Certain myeloid leukemia cells, particularly the acute promyelocytic leukemia (APL) subset, undergo terminal granulocytic differentiation in response to retinoic acid (RA). RA mediates its biologic effects through specific retinoic acid receptors (RA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce683e10fadf5b078045bb5ae926b09f
https://doi.org/10.1016/j.bcmd.2007.05.009
https://doi.org/10.1016/j.bcmd.2007.05.009
Publikováno v:
Journal of Clinical Investigation. 117:1412-1421
Retinoic acid receptors (RARs) are members of the nuclear hormone receptor family and regulate the proliferation and differentiation of multiple different cell types, including promyelocytic leukemia cells. Here we describe a biochemical/functional i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8033c81dab66b2319d9f4ec856b5113c
https://doi.org/10.1172/jci30779
https://doi.org/10.1172/jci30779
Publikováno v:
Blood. 99:746-753
The disruption of retinoic acid receptor (RAR) activity that characterizes human acute promyelocytic leukemia (APL) is associated with a block to granulocytic differentiation indicating that RARs are critical regulators of normal myeloid differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef948c5442be1117e93bfdacd8167049
https://doi.org/10.1182/blood.v99.3.746
https://doi.org/10.1182/blood.v99.3.746
Publikováno v:
Blood. 88:2517-2530
Retinoic acid (RA)-induced maturation mediated by the retinoic acid receptor alpha (RAR alpha) has been implicated in myeloid development. We have used differential hybridization analysis of a cDNA library constructed from the murine RA-inducible MPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68d1157efda6d6f93ed56096d0083b4a
https://doi.org/10.1182/blood.v88.7.2517.bloodjournal8872517
https://doi.org/10.1182/blood.v88.7.2517.bloodjournal8872517
Publikováno v:
Molecular and Cellular Biology. 12:3743-3749
The complex and diverse biological effects of retinoic acid (RA) are mediated through specific receptors that are members of the steroid hormone family of nuclear transcription factors. The RA receptor family consists of multiple structurally distinc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f19a505e58bd33489cc9872df4e27cf
https://doi.org/10.1128/mcb.12.9.3743
https://doi.org/10.1128/mcb.12.9.3743
Publikováno v:
Blood. 77:340-347
Although mRNA for the retinoic acid receptor alpha (RAR-alpha) is expressed in many different myeloid leukemias, most of these leukemia cells exhibit little if any phenotypic response when exposed to retinoic acid (RA). To determine whether such RA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d430cbd7c27ae81a46e07d849a20291a
https://doi.org/10.1182/blood.v77.2.340.340
https://doi.org/10.1182/blood.v77.2.340.340
Publikováno v:
Molecular and Cellular Biology. 10:2154-2163
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d183395f17c01a05aeac4c3a64208f3
https://doi.org/10.1128/mcb.10.5.2154-2163.1990
https://doi.org/10.1128/mcb.10.5.2154-2163.1990
Publikováno v:
Molecular and Cellular Biology. 10:2154-2163
Retinoic acid (RA) induces terminal granulocytic differentiation of the HL-60 promyelocytic leukemia cell line as well as certain other human myeloid leukemias. Specific RA receptors that are members of the steroid-thyroid hormone superfamily of nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1c8fc94af451ef464a15a0749d0c810
https://doi.org/10.1128/mcb.10.5.2154
https://doi.org/10.1128/mcb.10.5.2154
Publikováno v:
Leukemia research. 31(5)
KN-62, an inhibitor of the calmodulin-dependent protein kinases (CaMKs), enhances the terminal differentiation of retinoic acid sensitive human myeloid leukemia cell lines. In an effort to identify additional CaMK inhibitors that exhibit more potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81e6c046d8c613e1405de996a8d971b
https://pubmed.ncbi.nlm.nih.gov/16963120
https://pubmed.ncbi.nlm.nih.gov/16963120
Autor:
Steven J. Collins, Richard A. Heyman, LeMoyne Mueller, Elizabeth A. Allegretto, Barton S. Johnson, Roshantha A.S. Chandraratna
The multiple biologic activities of retinoic acid (RA) are mediated through RAR and retinoid X receptor (RXR) nuclear receptors that interact with specific DNA target sequences as heterodimers (RXR-RAR) or homodimers (RXR-RXR). RA receptor activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edf97f7633e276fef13c402496df3d0
https://europepmc.org/articles/PMC84130/
https://europepmc.org/articles/PMC84130/
