AMPK-mediated regulation of endogenous cholesterol synthesis does not affect atherosclerosis in a murine Pcsk9-AAV model.

Autor: Smith TKT; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Ghorbani P; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., LeBlond ND; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Nunes JRC; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., O'Dwyer C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Ambursley N; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Fong-McMaster C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Minarrieta L; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Burkovsky LA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., El-Hakim R; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Trzaskalski NA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., Locatelli CAA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., Stotts C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., Pember C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Rayner KJ; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., Kemp BE; Protein Chemistry and Metabolism, St. Vincent's Institute of Medical Research, Fitzroy, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia., Loh K; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia., Harper ME; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Mulvihill EE; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada., St-Pierre J; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada., Fullerton MD; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, ON, Canada; Centre for Catalysis Research and Innovation, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada. Electronic address: morgan.fullerton@uottawa.ca.

Publikováno v: Atherosclerosis [Atherosclerosis] 2024 Oct; Vol. 397, pp. 117608. Date of Electronic Publication: 2024 Jun 03.

Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice.

Autor: LeBlond ND; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, Ontario, Canada; Centre for Catalysis Research and Innovation, Ottawa, Ontario, Canada., Ghorbani P; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, Ontario, Canada; Centre for Catalysis Research and Innovation, Ottawa, Ontario, Canada., O'Dwyer C; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, Ontario, Canada; Centre for Catalysis Research and Innovation, Ottawa, Ontario, Canada., Ambursley N; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada., Nunes JRC; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, Ontario, Canada; Centre for Catalysis Research and Innovation, Ottawa, Ontario, Canada., Smith TKT; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, Ontario, Canada; Centre for Catalysis Research and Innovation, Ottawa, Ontario, Canada., Trzaskalski NA; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, Ontario, Canada; University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Mulvihill EE; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, Ontario, Canada; University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Viollet B; Université de Paris, Institut Cochin, CNRS, INSERM, Paris, France., Foretz M; Université de Paris, Institut Cochin, CNRS, INSERM, Paris, France., Fullerton MD; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Centre for Infection, Immunity and Inflammation, Ottawa, Ontario, Canada; Centre for Catalysis Research and Innovation, Ottawa, Ontario, Canada. Electronic address: morgan.fullerton@uottawa.ca.

Publikováno v: Journal of lipid research [J Lipid Res] 2020 Dec; Vol. 61 (12), pp. 1697-1706. Date of Electronic Publication: 2020 Sep 25.

Hepatic Choline Transport Is Inhibited During Fatty Acid-Induced Lipotoxicity and Obesity.

Autor: O'Dwyer C; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Yaworski R; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Katsumura S; Department of Molecular Medicine University of Texas Health Science Center at San Antonio San Antonio TX., Ghorbani P; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Gobeil Odai K; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Nunes JRC; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., LeBlond ND; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Sanjana S; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Smith TTK; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Han S; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Margison KD; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Alain T; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada.; Children's Hospital of Eastern Ontario Research Institute Ottawa ON Canada., Morita M; Department of Molecular Medicine University of Texas Health Science Center at San Antonio San Antonio TX.; Barshop Institute for Longevity and Aging Studies University of Texas Health Science Center at San Antonio San Antonio TX.; Institute of Resource Development and Analysis Kumamoto University Kumamoto Japan., Fullerton MD; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada.

Publikováno v: Hepatology communications [Hepatol Commun] 2020 Apr 10; Vol. 4 (6), pp. 876-889. Date of Electronic Publication: 2020 Apr 10 (Print Publication: 2020).

Maternal choline supplementation in neurodevelopmental disorders: mechanistic insights from animal models and future directions.

Autor: King, Cole¹ (AUTHOR), Plakke, Bethany¹ (AUTHOR) bplakke@ksu.edu

Publikováno v: Nutritional Neuroscience. Jul2024, p1-20. 20p. 3 Illustrations.

A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling.

Autor: van der Veen JN; Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada.; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada., Lingrell S; Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada.; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada., McCloskey N; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., LeBlond ND; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Galleguillos D; Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada.; Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada; and., Zhao YY; Department of Agricultural, Food, and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada., Curtis JM; Department of Agricultural, Food, and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada., Sipione S; Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada.; Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada; and., Fullerton MD; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Vance DE; Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada.; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada., Jacobs RL; Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada.; Department of Agricultural, Food, and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Apr; Vol. 33 (4), pp. 5045-5057. Date of Electronic Publication: 2019 Jan 07.