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P2.12-05 Cancer and Atopy: Parallel Drivers? IL-4 Blockade Synergizes with PD-L1 Blockade to Reverse Type-2Mediated Immunosuppression.

Autor: Marron, T.U., Maier, B., LaMarche, N.M., Hegde, S., Belabed, M., Mattiuz, R., Hennequin, C., LeBerichel, J., Park, M.D., Hall, N., Ogrady, D., Fitzgerald, B., Gomez, J.E., Doroshow, D.B., Veluswamy, R., Rolfo, C., Smith, C.B., Rohs, N., Yankelevitz, D., Chaddha, U.

Publikováno v: Journal of Thoracic Oncology; 2022 Supplement, Vol. 17 Issue 9, pS153-S154, 2p

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Shift of lung macrophage composition is associated with COVID-19 disease severity and recovery.

Autor: Chen ST; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Park MD; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Del Valle DM; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Buckup M; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Tabachnikova A; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Simons NW; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Mouskas K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Lee B; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Geanon D; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., D'Souza D; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Dawson T; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Marvin R; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Nie K; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Thompson RC; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, 10029, USA., Zhao Z; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., LeBerichel J; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Chang C; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Jamal H; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Chaddha U; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Mathews K; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Acquah S; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Brown SA; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Reiss M; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Harkin T; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Feldmann M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK., Powell CA; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Hook JL; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Kim-Schulze S; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Rahman AH; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Immunai, New York, NY, USA., Brown BD; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, 10029, USA., Beckmann ND; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, 10029, USA., Gnjatic S; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Kenigsberg E; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, 10029, USA., Charney AW; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Merad M; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2022 Jan 12. Date of Electronic Publication: 2022 Jan 12.