Socioeconomic Status and the Gut Microbiome: A TwinsUK Cohort Study

Autor: Bowyer, RCE, Jackson, MA, Le Roy, CI, Ni Lochlainn, M, Spector, TD, Dowd, JB, Steves, CJ

Publikováno v: Microorganisms
Volume 7
Issue 1
Microorganisms, Vol 7, Iss 1, p 17 (2019)

Socioeconomic inequalities in health and mortality are well established, but the biological mechanisms underlying these associations are less understood. In parallel, the gut microbiome is emerging as a potentially important determinant of human heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9594b9582806bad700f2d399c7f5824b

A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning.

Autor: Vatanen T; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Liggins Institute, University of Auckland, New Zealand., Ang QY; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Siegwald L; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland., Sarker SA; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Le Roy CI; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland., Duboux S; Nestlé Institute of Material Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland., Delannoy-Bruno O; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland., Ngom-Bru C; Nestlé Institute of Food Safety and Analytical Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland., Boulangé CL; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland., Stražar M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Avila-Pacheco J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Deik A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pierce K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bullock K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dennis C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sultana S; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Sayed S; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Rahman M; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Ahmed T; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Modesto M; Department of Agricultural and Food Sciences, University of Bologna, Viale Fanin 42, 40127 Bologna, Italy., Mattarelli P; Department of Agricultural and Food Sciences, University of Bologna, Viale Fanin 42, 40127 Bologna, Italy., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Plichta DR; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA., Sakwinska O; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland. Electronic address: olga.sakwinska@rdls.nestle.com., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA. Electronic address: rxavier@broadinstitute.org.

Publikováno v: Cell [Cell] 2022 Nov 10; Vol. 185 (23), pp. 4280-4297.e12. Date of Electronic Publication: 2022 Nov 01.

Yoghurt consumption is associated with changes in the composition of the human gut microbiome and metabolome.

Autor: Le Roy CI; Department of Twin Research & Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Kurilshikov A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Leeming ER; Department of Twin Research & Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Visconti A; Department of Twin Research & Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Bowyer RCE; Department of Twin Research & Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Menni C; Department of Twin Research & Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Falchi M; Department of Twin Research & Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Koutnikova H; Danone Nutricia Research, Palaiseau, France., Veiga P; Danone Nutricia Research, Palaiseau, France., Zhernakova A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Derrien M; Danone Nutricia Research, Palaiseau, France. Muriel.DERRIEN@danone.com., Spector TD; Department of Twin Research & Genetic Epidemiology, King's College London, London, SE1 7EH, UK. tim.spector@kcl.ac.uk.

Publikováno v: BMC microbiology [BMC Microbiol] 2022 Feb 03; Vol. 22 (1), pp. 39. Date of Electronic Publication: 2022 Feb 03.

Large-scale association analyses identify host factors influencing human gut microbiome composition.

Autor: Kurilshikov A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. alexa.kur@gmail.com., Medina-Gomez C; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; The Generation R Study, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Bacigalupe R; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; Center for Microbiology, VIB, Leuven, Belgium., Radjabzadeh D; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Wang J; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; Center for Microbiology, VIB, Leuven, Belgium.; Institute of Microbiology, Chinese Academy of Sciences, Beijing, China., Demirkan A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Section of Statistical Multi-Omics, Department of Clinical & Experimental Medicine, School of Biosciences & Medicine, University of Surrey, Guildford, UK., Le Roy CI; Department of Twin Research & Genetic Epidemiology, King's College London, London, UK., Raygoza Garay JA; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Gastroenterology, Mount Sinai Hospital, Toronto, Ontario, Canada., Finnicum CT; Avera Institute of Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA., Liu X; Center for Molecular Medicine and Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Zhernakova DV; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Laboratory of Genomic Diversity, Center for Computer Technologies, ITMO University, St. Petersburg, Russia., Bonder MJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Hansen TH; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Frost F; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany., Rühlemann MC; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Turpin W; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Gastroenterology, Mount Sinai Hospital, Toronto, Ontario, Canada., Moon JY; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Kim HN; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea., Lüll K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Barkan E; Department of Computer Science and Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Shah SA; COPSAC, Copenhagen University Hospital, Copenhagen, Denmark., Fornage M; Institute of Molecular Medicine McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Szopinska-Tokov J; Department of Psychiatry, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands., Wallen ZD; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Borisevich D; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Agreus L; Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Andreasson A; Stress Research Institute, Stockholm University, Stockholm, Sweden., Bang C; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Bedrani L; Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Bell JT; Department of Twin Research & Genetic Epidemiology, King's College London, London, UK., Bisgaard H; COPSAC, Copenhagen University Hospital, Copenhagen, Denmark., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Boomsma DI; Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands., Burk RD; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA., Claringbould A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Croitoru K; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Gastroenterology, Mount Sinai Hospital, Toronto, Ontario, Canada., Davies GE; Avera Institute of Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA.; Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands., van Duijn CM; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Duijts L; The Generation R Study, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Falony G; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; Center for Microbiology, VIB, Leuven, Belgium., Fu J; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., van der Graaf A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Homuth G; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Hughes DA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, Bristol, UK., Ijzerman RG; Department of Endocrinology, Amsterdam University Medical Center, location VUMC, Amsterdam, the Netherlands., Jackson MA; Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Jaddoe VWV; The Generation R Study, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Joossens M; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; Center for Microbiology, VIB, Leuven, Belgium., Jørgensen T; Centre for Clinical Research and Prevention, Bispebjerg/Frederiksberg Hospital, Capital Region of Copenhagen and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Keszthelyi D; Division of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands.; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands., Knight R; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation and Department of Bioengeering, University of California, San Diego, La Jolla, CA, USA., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Laudes M; Department of Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Launer LJ; Laboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD, USA., Lieb W; Institute of Epidemiology, Kiel University, Kiel, Germany., Lusis AJ; Departments of Microbiology, Immunology and Molecular Genetics, and Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Masclee AAM; Division of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands.; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands., Moll HA; Department of Pediatrics, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Mujagic Z; Division of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands.; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands., Qibin Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Rothschild D; Department of Computer Science and Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Shin H; Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Sørensen SJ; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Steves CJ; Department of Twin Research & Genetic Epidemiology, King's College London, London, UK., Thorsen J; COPSAC, Copenhagen University Hospital, Copenhagen, Denmark., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, Bristol, UK., Tito RY; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; Center for Microbiology, VIB, Leuven, Belgium., Vieira-Silva S; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; Center for Microbiology, VIB, Leuven, Belgium., Völker U; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Võsa U; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Wade KH; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, Bristol, UK., Walter S; Department of Biomedical and Clinical Sciences, University of Linköping, Linköping, Sweden.; Department of Gastroenterology, County Council of Östergötland, Linköping, Sweden., Watanabe K; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Amsterdam, the Netherlands., Weiss S; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Weiss FU; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany., Weissbrod O; School of Public Health, Harvard University, Boston, MA, USA., Westra HJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Willemsen G; Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands., Payami H; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Jonkers DMAE; Division of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands.; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands., Arias Vasquez A; Department of Psychiatry, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.; Department of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands., de Geus EJC; Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam UMC, Amsterdam, the Netherlands., Meyer KA; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA., Stokholm J; COPSAC, Copenhagen University Hospital, Copenhagen, Denmark., Segal E; Department of Computer Science and Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Org E; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Wijmenga C; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Kim HL; Department of Biochemistry, Ewha Womans University School of Medicine, Seoul, Republic of Korea., Kaplan RC; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Spector TD; Department of Twin Research & Genetic Epidemiology, King's College London, London, UK., Uitterlinden AG; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; The Generation R Study, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Rivadeneira F; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; The Generation R Study, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Lerch MM; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany., Franke L; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Sanna S; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Istituto di Ricerca Genetica e Biomedica, National Research Council, Monserrato, Italy., D'Amato M; Center for Molecular Medicine and Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.; Department of Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastián, Spain.; Ikerbasque, Basque Science Foundation, Bilbao, Spain., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Paterson AD; Genetics and Genome Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada., Kraaij R; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Raes J; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; Center for Microbiology, VIB, Leuven, Belgium., Zhernakova A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. sasha.zhernakova@gmail.com.

Publikováno v: Nature genetics [Nat Genet] 2021 Feb; Vol. 53 (2), pp. 156-165. Date of Electronic Publication: 2021 Jan 18.

A reference map of potential determinants for the human serum metabolome.

Autor: Bar N; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Korem T; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.; CIFAR Azrieli Global Scholars Program, CIFAR, Toronto, Ontario, Canada., Weissbrod O; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Zeevi D; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Center for Studies in Physics and Biology, The Rockefeller University, New York, NY, USA., Rothschild D; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Leviatan S; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Kosower N; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Lotan-Pompan M; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Weinberger A; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Le Roy CI; Department for Twin Research & Genetic Epidemiology, King's College London, London, UK., Menni C; Department for Twin Research & Genetic Epidemiology, King's College London, London, UK., Visconti A; Department for Twin Research & Genetic Epidemiology, King's College London, London, UK., Falchi M; Department for Twin Research & Genetic Epidemiology, King's College London, London, UK., Spector TD; Department for Twin Research & Genetic Epidemiology, King's College London, London, UK., Adamski J; Research Unit Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Franks PW; Lund University Diabetes Center, Department of Clinical Sciences, Lund University, Malmö, Sweden.; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Segal E; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel. eran.segal@weizmann.ac.il.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. eran.segal@weizmann.ac.il.

Publikováno v: Nature [Nature] 2020 Dec; Vol. 588 (7836), pp. 135-140. Date of Electronic Publication: 2020 Nov 11.