R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth

Autor: CHASSOT, Anne Amandine, De Cian, Marie-Cécile, Gregoire, Elodie, Le Rolle, Morgane, Lachambre, Simon, Mondin, Magali, Bell, Sheila, Guigon, Céline, Chassot, Anne-Amandine, Chaboissier, Marie-Christine

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, 2020, 27 (10), pp.2856-2871. ⟨10.1038/s41418-020-0547-7⟩
Cell Death and Differentiation, Nature Publishing Group, 2020, 27 (10), pp.2856-2871. ⟨10.1038/s41418-020-0547-7⟩
Cell Death and Differentiation, Nature Publishing Group, 2020, 27, pp.2856-2871. ⟨10.1038/s41418-020-0547-7⟩
Cell Death and Differentiation, Nature Publishing Group, 2020, ⟨10.1038/s41418-020-0547-7⟩

R-spondin2 (RSPO2) is a member of the R-spondin family, which are secreted activators of the WNT/β-catenin (CTNNB1) signaling pathway. In the mouse postnatal ovary, WNT/CTNNB1 signaling is active in the oocyte and in the neighboring supporting cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3550745c83c4ac22cb564ba8af2309
https://hal.science/hal-02992481

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WNT/β-catenin signaling pathway and germ cell differentiation in mammals

Autor: Le Rolle, Morgane

Publikováno v: Biologie de la reproduction. COMUE Université Côte d'Azur (2015-2019), 2019. Français. ⟨NNT : 2019AZUR6014⟩

Since the last decennials, fertility is decreasing in industrial countries, and nowadays, infertility reaches a prevalence of 9 to 18% of the general population, with a significant proportion of cases being due to defective gametogenesis. Accordingly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::0ead2a2d411f42929f26bd6694507b1c
https://theses.hal.science/tel-03505553