Inhibitor‐induzierte Dimerisierung einer essentiellen Oxidoreduktase aus afrikanischen Trypanosomen.

Autor: Wagner, Annika^1,2, Le, Thien Anh³, Brennich, Martha⁴, Klein, Philipp⁵, Bader, Nicole⁶, Diehl, Erika^1,2, Paszek, Daniel¹, Weickhmann, A. Katharina², Dirdjaja, Natalie⁷, Krauth‐Siegel, R. Luise⁷, Engels, Bernd³, Opatz, Till⁵, Schindelin, Hermann⁶ hermann.schindelin@virchow.uni-wuerzburg.de, Hellmich, Ute A.^1,2 u.hellmich@uni-mainz.de

Publikováno v: Angewandte Chemie. 3/11/2019, Vol. 131 Issue 11, p3679-3683. 5p.

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Inhibitor‐Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.

Autor: Wagner, Annika, Le, Thien Anh, Brennich, Martha, Klein, Philipp, Bader, Nicole, Diehl, Erika, Paszek, Daniel, Weickhmann, A. Katharina, Dirdjaja, Natalie, Krauth‐Siegel, R. Luise, Engels, Bernd, Opatz, Till, Schindelin, Hermann, Hellmich, Ute A.

Publikováno v: Angewandte Chemie International Edition; 3/11/2019, Vol. 58 Issue 11, p3640-3644, 5p

Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases—Studies on Inhibition Mechanism and Kinetics.

Autor: Klein, Philipp, Barthels, Fabian, Johe, Patrick, Wagner, Annika, Tenzer, Stefan, Distler, Ute, Le, Thien Anh, Schmid, Paul, Engel, Volker, Engels, Bernd, Hellmich, Ute A., Opatz, Till, Schirmeister, Tanja

Publikováno v: Molecules; May2020, Vol. 25 Issue 9, p2064, 1p, 3 Diagrams, 5 Charts, 9 Graphs

A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure.

Autor: Eltschkner S; Rudolf Virchow Center for Integrative and Translational Bioimaging, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany.; Molecular Ecology and Evolution Lab, Department of Biology, Lund University, 223 62 Lund, Sweden., Kehrein J; Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany., Le TA; Institute of Physical and Theoretical Chemistry, University of Würzburg, 97074 Würzburg, Germany.; Department of Experimental Physics 5 (Biophysics), University of Würzburg, 97074 Würzburg, Germany., Davoodi S; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States., Merget B; Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany., Basak S; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States., Weinrich JD; Rudolf Virchow Center for Integrative and Translational Bioimaging, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany.; Department of Microbiology, Biocenter, University of Würzburg, 97074 Würzburg, Germany., Schiebel J; Rudolf Virchow Center for Integrative and Translational Bioimaging, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany., Tonge PJ; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States., Engels B; Institute of Physical and Theoretical Chemistry, University of Würzburg, 97074 Würzburg, Germany., Sotriffer C; Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany., Kisker C; Rudolf Virchow Center for Integrative and Translational Bioimaging, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2021 Apr 09; Vol. 7 (4), pp. 746-758. Date of Electronic Publication: 2021 Mar 12.