Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Laziza Amniai"'
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Akademický článek
Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.
Autor: Isabelle Landrieu, Caroline Smet-Nocca, Laziza Amniai, Justin Vijay Louis, Jean-Michel Wieruszeski, Jozef Goris, Veerle Janssens, Guy Lippens
Publikováno v: PLoS ONE, Vol 6, Iss 6, p e21521 (2011)
Tau phosphorylation and dephosphorylation regulate in a poorly understood manner its physiological role of microtubule stabilization, and equally its integration in Alzheimer disease (AD) related fibrils. A specific phospho-pattern will result from t
Externí odkaz: https://doaj.org/article/21141210c88a435cac1fad79244717ea
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2
Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein
Autor: Nathalie Sibille, Dries Verdegem, Laziza Amniai, Jean-Michel Wieruszeski, Guy Lippens, Caroline Fauquant, Isabelle Landrieu, Isabelle Huvent, Arnaud Leroy
Publikováno v: Proteins: Structure, Function, and Bioinformatics. 80:454-462
Phosphorylation of the neuronal Tau protein is implicated in both the regulation of its physiological function of microtubule stabilization and its pathological propensity to aggregate into the fibers that characterize Alzheimer's diseased neurons. H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8a4db2d41e24b84882517e2d9b3283b
https://doi.org/10.1002/prot.23210
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3
A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein
Autor: Predrag Kukic, Yves Jacquot, Isabelle Landrieu, Guy Lippens, Neha S. Gandhi, Ricardo L. Mancera, Jean-Michel Wieruszeski, Laziza Amniai, Cillian Byrne, François-Xavier Cantrelle
Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2015, 127 (23), pp.6923-6927 ⟨10.1002/ange.201501898⟩
Angewandte Chemie (English Edition)
Angewandte Chemie (English Edition), John Wiley & Sons, 2015, 127 (23), pp.6923-6927 ⟨10.1002/ange.201501898⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2015, 127 (23), pp.6923-6927 ⟨10.1002/ange.201501898⟩
Post mortem biochemical staging of Alzheimer’s disease is currently based on immunochemical analysis of brain slices with the AT8 antibody. The epitope of AT8 is described around the pSer202/pThr205 region of the hyperphosphorylated form of the neu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cbbeb98280503cfb454907c016fd9a
https://hal.science/hal-01145963
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4
Towards understanding the phosphorylation code of tau
Autor: Laziza Amniai, Arnaud Leroy, Guy Lippens, Alain Sillen, Isabelle Landrieu, Jean Michel Wieruszeski
Publikováno v: Biochemical Society Transactions
Biochemical Society Transactions, Portland Press, 2012, 40 (4), pp.698-703. ⟨10.1042/BST20120050⟩
Biochemical Society Transactions, 2012, 40 (4), pp.698-703. ⟨10.1042/BST20120050⟩
International audience; We describe our efforts to combine in vitro enzymatic reactions with recombinant kinases to phosphorylate the neuronal tau protein, and NMR spectroscopy to unravel the resulting phosphorylation pattern in both qualitative and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cb75a6a55e9c4ec9e4b7567f29791b
https://hal.archives-ouvertes.fr/hal-00765867
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5
Characterization of the AT180 epitope of phosphorylated Tau protein by a combined nuclear magnetic resonance and fluorescence spectroscopy approach
Autor: Isabelle Landrieu, Laziza Amniai, Guy Lippens
Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2011, epub ahead of print. ⟨10.1016/j.bbrc.2011.08.046⟩
Biochemical and Biophysical Research Communications, 2011, epub ahead of print. ⟨10.1016/j.bbrc.2011.08.046⟩
International audience; We present here the characterization of the epitope recognized by the AT180 monoclonal antibody currently used to define an Alzheimer's disease (AD)-related pathological form of the phosphorylated Tau protein. Some ambiguity r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfb10469eb7df771edcddf42a0cf61e
https://hal.archives-ouvertes.fr/hal-00618266
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6
NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease
Autor: Arnaud Leroy, Isabelle Huvent, Luc Buée, Isabelle Landrieu, Malika Hamdane, Guy Lippens, Caroline Smet-Nocca, Laziza Amniai, Jean-Michel Wieruszeski, Nathalie Sibille
Publikováno v: Biochemical Society Transactions
Biochemical Society Transactions, Portland Press, 2010, 38 (4), pp.1006-11. ⟨10.1042/BST0381006⟩
Biochemical Society Transactions, 2010, 38 (4), pp.1006-11. ⟨10.1042/BST0381006⟩
International audience; NMR spectroscopy was used to explore the different aspects of the normal and pathological functions of tau, but proved challenging because the protein contains 441 amino acids and has poor signal dispersion. We have set out to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1da2ed025b8d8b7e3d66c14d9d171ad
https://pubmed.ncbi.nlm.nih.gov/20658994
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7
NMR observation of Tau in Xenopus oocytes
Autor: Guy Lippens, Arlette Rousseau-Lescuyer, Jean-Michel Wieruszeski, Jean-François Bodart, Isabelle Landrieu, Laziza Amniai, Arnaud Leroy, Jean-Pierre Vilain
Publikováno v: Journal of Magnetic Resonance
Journal of Magnetic Resonance, Elsevier, 2008, epub ahead of print. ⟨10.1016/j.jmr.2008.03.006⟩
Journal of Magnetic Resonance, 2008, epub ahead of print. ⟨10.1016/j.jmr.2008.03.006⟩
The observation by NMR spectroscopy of microinjected (15)N-labelled proteins into Xenopus laevis oocytes might open the way to link structural and cellular biology. We show here that embedding the oocytes into a 20% Ficoll solution maintains their st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9632bf6c16be66e839675d167f350b7
https://hal.archives-ouvertes.fr/hal-00273308
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8
Tau Aggregation in Alzheimer's Disease: What Role for Phosphorylation?
Autor: Alain Sillen, Xavier Hanoulle, Arnaud Leroy, Pascale Barbier, Guy Lippens, Laziza Amniai, Jean-Michel Wieruszeski, Isabelle Landrieu, Nathalie Sibille
Publikováno v: Prion
Prion, Taylor & Francis, 2007, 1 (1), pp.21-25
Prion, 2007, 1 (1), pp.21-25
The crucial role of the neuronal Tau protein in microtubule stabilization and axonal transport suggests that too little or too much Tau might lead to neuronal dysfunction. The presence of a hyper phosphorylated but non aggregated molecule as a toxic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08f1e5cfd416f8cf6fd16ef276d8b9e
https://europepmc.org/articles/PMC2633703/
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