Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lazer Edward S"'
Autor:
Sorcek Ronald J, Julian Adams, Lazer Edward S, J. M. Watrous, Yvan Guindon, H.‐C. Wong, Carol Ann Homon, Kollol Pal, Jürgen H. Nagel, Mark L. Behnke, A. Shah, Miao Clara K, A. G. Graham, A. Gilman, Denice M. Spero, Peter R. Farina
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ade8f0d4a443d8ee74fe9e365953d8c0
https://doi.org/10.1002/chin.199434152
https://doi.org/10.1002/chin.199434152
Autor:
Sorcek Ronald J, L. Churchill, Lazer Edward S, Genus J. Possanza, Charles L. Cywin, Diane Thome, A. G. Graham
Publikováno v:
ChemInform. 29
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase-2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f54a6a730de269c3f6fc944343649810
https://doi.org/10.1002/chin.199838165
https://doi.org/10.1002/chin.199838165
Publikováno v:
Journal of Medicinal Chemistry. 33:1892-1898
A series of 2,6-disubstituted 4-(2-arylethenyl)phenols with potent human neutrophil 5-lipoxygenase (5-LO) inhibiting activity (IC 50 s in the 10 −7 M range) and weaker human platelet cyclooxygenase (CO) inhibiting activity (IC 50 s in the 10 −6 M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabb742939bf04e8158da3e407aebf91
https://doi.org/10.1021/jm00169a010
https://doi.org/10.1021/jm00169a010
Autor:
Charles L. Cywin, Diane Thome, Lazer Edward S, A. G. Graham, Sorcek Ronald J, L. Churchill, Genus J. Possanza
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(10)
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase-2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cd313b3ca6af5229d7cbce67098888
https://pubmed.ncbi.nlm.nih.gov/9871731
https://pubmed.ncbi.nlm.nih.gov/9871731
Autor:
Sorcek Ronald J, Simon J. Coutts, L. Churchill, Eva David, Mcneil Daniel W, Gunter Trummlitz, Hin-Chor Wong, Peter M. Grob, Ian Potocki, Hans Meier, Matt Aaron Tschantz, Wolfhard Engel, Lazer Edward S, Miao Clara K, A. G. Graham, Terence A. Kelly, Charles L. Cywin, Maryann Hoermann, Zhaoxing Meng, Roger J. Snow
Publikováno v:
Journal of medicinal chemistry. 40(6)
Meloxicam (5), an NSAID in the enol-carboxamide class, was developed on the basis of its antiinflammatory activity and relative safety in animal models. In subsequent screening in microsomal assays using human COX-1 and COX-2, we discovered that it p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50186f66868fad80b86b655e901a13d8
https://pubmed.ncbi.nlm.nih.gov/9083488
https://pubmed.ncbi.nlm.nih.gov/9083488
Publikováno v:
The Search for Anti-Inflammatory Drugs ISBN: 9781461598480
Several events in the late 1970s and early 1980s helped to shape the research agenda for pharmaceutical companies engaged in the search for a new generation of anti-inflammatory agents. The structural identity of the arachi- donic acid (AA) metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0b58d3cfce2c64bb4705318bb1b526c
https://doi.org/10.1007/978-1-4615-9846-6_9
https://doi.org/10.1007/978-1-4615-9846-6_9
Autor:
A. Gilman, Hin Chor Wong, Miao Clara K, Denice M. Spero, Kollol Pal, Mark L. Behnke, A. G. Graham, J. M. Watrous, Sorcek Ronald J, Lazer Edward S
Publikováno v:
Journal of medicinal chemistry. 37(7)
A series of benzoxazolamine and benzothiazolamine analogs that inhibit leukotriene (LT) biosynthesis are described. The initial lead, (S)-N-(benzothiazol-2- yl)phenylalanine ethyl ester (5a), was discovered in a screening program for inhibition of Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4b4c63e97b414e943b72649e4ef842
https://pubmed.ncbi.nlm.nih.gov/8151618
https://pubmed.ncbi.nlm.nih.gov/8151618
Autor:
Jager Paul D, L. Gordon Letts, Mark J. Kontny, C. C. Clarke, William M. Abraham, Peter R. Farina, Craig D. Wegner, Lazer Edward S, Carol A. Torcellini, Walter W. Wolyniec, R. H. Gundel, Edward S. Schulman, Carol Ann Homon, A. G. Graham
Publikováno v:
The Journal of allergy and clinical immunology. 91(4)
Background: The action of 5-lipoxygenase on arachidonic acid generates potent inflammatory mediators that may contribute to the pathophysiology of asthma. Methods: Using the potent and selective 5-lipoxygenase inhibitor BI-L-239, we have examined the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5188333ae7367b87f6f47c3155891a3e
https://pubmed.ncbi.nlm.nih.gov/8473681
https://pubmed.ncbi.nlm.nih.gov/8473681
Autor:
Mark J. Kontny, Walter W. Wolyniec, L. G. Letts, Lazer Edward S, A. M. LaPlante, Craig D. Wegner
Publikováno v:
Agents and actions. 34(1-2)
Male Hartley guinea pigs were actively sensitized to ovalbumin (OA). Respiratory system resistance (Rrs) was measured by forced oscillations superimposed on tidal breathing. Airway responsiveness (inhaled methacholine PC100) was determined three days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813486773300e3c777dc2c5727aea93e
https://pubmed.ncbi.nlm.nih.gov/1793056
https://pubmed.ncbi.nlm.nih.gov/1793056
Autor:
L. G. Letts, William M. Abraham, Mark J. Kontny, Peter R. Farina, Lazer Edward S, Edward S. Schulman, R. H. Gundel, Craig D. Wegner
Publikováno v:
Journal of Allergy and Clinical Immunology. 87:313
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17a90d92a7945c13662881e7b4ffbda7
https://doi.org/10.1016/0091-6749(91)91975-y
https://doi.org/10.1016/0091-6749(91)91975-y