Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Lazaros C. Foukas"'
Autor:
Sarah E. Conduit, Wayne Pearce, Amandeep Bhamra, Benoit Bilanges, Laura Bozal-Basterra, Lazaros C. Foukas, Mathias Cobbaut, Sandra D. Castillo, Mohammad Amin Danesh, Mahreen Adil, Arkaitz Carracedo, Mariona Graupera, Neil Q. McDonald, Peter J. Parker, Pedro R. Cutillas, Silvia Surinova, Bart Vanhaesebroeck
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Primary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia disassembly, the proc
Externí odkaz:
https://doaj.org/article/73d0a1177d1d4ad6bd109cda96644ef1
Autor:
Carina C. Kern, StJohn Townsend, Antoine Salzmann, Nigel B. Rendell, Graham W. Taylor, Ruxandra M. Comisel, Lazaros C. Foukas, Jürg Bähler, David Gems
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
It is unclear why C. elegans continues to produce large quantities of yolk after reproduction. Here the authors show that post-reproductive C. elegans mothers vent yolk which supports their offspring’s growth, serving as a form of primitive lactati
Externí odkaz:
https://doaj.org/article/055664668cb24b469c3a15be409762ad
Autor:
Caroline Araiz, Anqi Yan, Lucia Bettedi, Isabella Samuelson, Sam Virtue, Anne K. McGavigan, Christian Dani, Antonio Vidal-Puig, Lazaros C. Foukas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancin
Externí odkaz:
https://doaj.org/article/f62feb23d732418d85b428408797a4db
Autor:
Caroline Araiz, Anqi Yan, Lucia Bettedi, Isabella Samuelson, Sam Virtue, Anne K. McGavigan, Christian Dani, Antonio Vidal-Puig, Lazaros C. Foukas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/280545492a2b43cfbd5468960feae291
Autor:
Lazaros C. Foukas, Benoit Bilanges, Lucia Bettedi, Wayne Pearce, Khaled Ali, Sara Sancho, Dominic J. Withers, Bart Vanhaesebroeck
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 4, Pp 563-571 (2013)
Abstract The insulin/insulin‐like growth factor‐1 signalling (IIS) pathway regulates cellular and organismal metabolism and controls the rate of aging. Gain‐of‐function mutations in p110α, the principal mammalian IIS‐responsive isoform of
Externí odkaz:
https://doaj.org/article/df865ab73972452abb15dcff32eb9aca
Autor:
Jürg Bähler, Graham W. Taylor, StJohn Townsend, Lazaros C. Foukas, Ruxandra M. Comisel, Nigel B. Rendell, Antoine Salzmann, Carina C. Kern, David Gems
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The nematode Caenorhabditis elegans exhibits rapid senescence that is promoted by the insulin/IGF-1 signalling (IIS) pathway via regulated processes that are poorly understood. IIS also promotes production of yolk for egg provisioning, which in post-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7823c7ce4a238cab80caf945e19499
https://pubmed.ncbi.nlm.nih.gov/34611154
https://pubmed.ncbi.nlm.nih.gov/34611154
Autor:
Comisel Rm, StJohn Townsend, Nigel B. Rendell, Antoine Salzmann, Carina C. Kern, David Gems, Jürg Bähler, Graham W. Taylor, Lazaros C. Foukas
AdultC. eleganshermaphrodites exhibit severe senescent pathology that begins to develop within days of reaching sexual maturity (Ezcurra et al., 2018; Garigan et al., 2002; Herndon et al., 2002; Wang et al., 2018). For example, after depletion of sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21197b8711496131c6e5557d44c480f6
https://doi.org/10.1101/2020.11.15.380253
https://doi.org/10.1101/2020.11.15.380253
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12813, p 12813 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12813
International Journal of Molecular Sciences, Vol 22, Iss 12813, p 12813 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12813
Attribution of specific roles to the two ubiquitously expressed PI 3-kinase (PI3K) isoforms p110α and p110β in biological functions they have been implicated, such as in insulin signalling, has been challenging. While p110α has been demonstrated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c2f37f34155a5fad9252002f54fcc2
https://pubmed.ncbi.nlm.nih.gov/34884613
https://pubmed.ncbi.nlm.nih.gov/34884613
Autor:
Lucia Bettedi, Lazaros C. Foukas
Publikováno v:
Biogerontology
The field of the biology of ageing has received increasing attention from a biomedical point of view over the past decades. The main reason has been the realisation that increases in human population life expectancy are accompanied by late onset dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a192a46b275f02e7e8ec248b03d7de11
http://europepmc.org/articles/PMC5684302
http://europepmc.org/articles/PMC5684302
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
The Insulin/IGF-1 signalling (IIS) pathway plays an essential role in the regulation of glucose and lipid homeostasis. At the same time, a reduction in the IIS pathway activity can extend lifespan and healthspan in various model organisms. Amongst a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c498465df7627c695dba065b26b80146
https://pubmed.ncbi.nlm.nih.gov/32099025
https://pubmed.ncbi.nlm.nih.gov/32099025