Výsledky vyhledávání

Akademický článek

The Design and Evaluation of an l-Dopa–Lazabemide Prodrug for the Treatment of Parkinson’s Disease

Autor: Monique Hoon, Jacobus P. Petzer, Francois Viljoen, Anél Petzer

Publikováno v: Molecules, Vol 22, Iss 12, p 2076 (2017)

l-Dopa, the metabolic precursor of dopamine, is the treatment of choice for the symptomatic relief of the advanced stages of Parkinson’s disease. The oral bioavailability of l-dopa, however, is only about 10% to 30%, and less than 1% of the oral do

Externí odkaz: https://doaj.org/article/0d4fec65e57e4c7c9ae7c750f5396f75

Zobrazit plný text záznamu

Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors

Autor: Sanal Dev, Anusree Venkidath, Bijo Mathew, Shebina P Rasheed, Nicola Gambacorta, Jong Min Oh, Ginson George, Hoon Kim, Ajeesh Vengamthodi, Ahmed Khames, Orazio Nicolotti, Mohamed A. Abdelgawad, Elham Amin

Publikováno v: Molecules
Volume 26
Issue 19
Molecules, Vol 26, Iss 6004, p 6004 (2021)

A small series of nitro group-bearing enamides was designed, synthesized (NEA1–NEA5), and evaluated for their inhibitory profiles of monoamine oxidases (MAOs) and β-site amyloid precursor protein cleaving enzyme 1 (β-secretase, BACE1). Compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc1558c8dfc7b9cd1784173697d4b71
https://pubmed.ncbi.nlm.nih.gov/34641548

Zobrazit plný text záznamu

Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors

Autor: Bijo Mathew, Nicola Gambacorta, Anna Rita Tondo, Raj Pal Singh, Hoon Kim, Manjula Singh, Reeta Chaudhary, Rishi Pal Singh, Jong Min Oh, T. M. Rangarajan, Orazio Nicolotti

Publikováno v: Molecules, Vol 25, Iss 2356, p 2356 (2020)
Molecules
Volume 25
Issue 10

Previously synthesized novel chalcone oxime ethers (COEs) were evaluated for inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Twenty-two of the 24 COEs synthesized, except COE-17 and COE-24, had potent and/or s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abc937d697e761da52b4ec0228ce853
https://www.mdpi.com/1420-3049/25/10/2356

Zobrazit plný text záznamu

Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase

Autor: Shiyang Zhou, Gangliang Huang, Guang-Ying Chen

Publikováno v: Bioorganic & Medicinal Chemistry. 26:4863-4870

In the studied a series novel of lazabemide derivatives were designed, synthesized and evaluated as inhibitors of monoamine oxidase (MAO-A or MAO-B). These compounds used lazabemide as the lead compound, and the chemistry structures were modified by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fdd4fd4cecec5003740d9d51a752cc
https://doi.org/10.1016/j.bmc.2018.08.024

Zobrazit plný text záznamu

Discovery of potent and reversible MAO-B inhibitors as furanochalcones

Autor: Bijo Mathew, Jerad Suresh, Hoon Kim, Seung Cheol Baek, Surya Parakkot Ramakrishnan

Publikováno v: International Journal of Biological Macromolecules. 108:660-664

A series of twelve furanochalcones (F1-F12) was synthesized and investigated for their human monoamine oxidase inhibitory activities. Among the series, compound (2E, 4E)-1-(furan-2-yl)-5-phenylpenta-2, 4-dien-1-one (F1), which was analyzed by single-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f315b45006817bd53e8a815a666dc092
https://doi.org/10.1016/j.ijbiomac.2017.11.159

Zobrazit plný text záznamu

Deep-learning-based target screening and similarity search for the predicted inhibitors of the pathways in Parkinson's disease

Autor: Abbas Khan, Nisar Ahmad, Dong-Qing Wei, Aman Chandra Kaushik, Syed Shujait Ali

Publikováno v: RSC advances. 9(18)

Herein, a two-step de novo approach was developed for the prediction of piperine targets and another prediction of similar (piperine) compounds from a small molecule library using a deep-learning method. Deep-learning and neural-network approaches we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e63eac9c616ca6f5ca79b6c4f40bf84
https://pubmed.ncbi.nlm.nih.gov/35520925

Zobrazit plný text záznamu

Perseveration in a spatial-discrimination serial reversal learning task is differentially affected by MAO-A and MAO-B inhibition and associated with reduced anxiety and peripheral serotonin levels

Autor: Sajeed Ali, Bianca Jupp, Jessica Griffiths, Peter Zhukovsky, Johan Alsiö, Errin Riley, Angela C. Roberts, Jing Xia, Lucy Jenner, Chiara Guiliano, Trevor W. Robbins, Jeffrey W. Dalley

Publikováno v: Psychopharmacology

$\textit{Rationale}$ Impairments in behavioral flexibility lie at the core of anxiety and obsessive-compulsive disorders. Few studies, however, have investigated the neural substrates of natural variation in behavioral flexibility and whether inflexi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7380da0ba76a76180c2dc6182bf96ca6
https://www.repository.cam.ac.uk/handle/1810/263998

Zobrazit plný text záznamu

Ethyl acetohydroxamate incorporated chalcones: Unveiling a novel class of chalcones for multitarget monoamine oxidase-b inhibitors against alzheimer's disease

Autor: Orazio Nicolotti, Jae Pil Lee, T. M. Rangarajan, Bijo Mathew, Hoon Kim, Giuseppe Felice Mangiatordi, Reeta, Manjula Singh, Ayushee, Seung Cheol Baek, Rishi Pal Singh

Publikováno v: CNS & neurological disorders. Drug targets 18 (2019): 643–654. doi:10.2174/1871527318666190906101326
info:cnr-pdr/source/autori:Reeta, null; Baek, Seung Cheol; Lee, Jae Pil; Rangarajan, T. M.; Ayushee, null; Singh, Rishi Pal; Singh, Manjula; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio; Kim, Hoon; Mathew, Bijo/titolo:Ethyl acetohydroxamate incorporated chalcones: Unveiling a novel class of chalcones for multitarget monoamine oxidase-b inhibitors against alzheimer's disease/doi:10.2174%2F1871527318666190906101326/rivista:CNS & neurological disorders. Drug targets/anno:2019/pagina_da:643/pagina_a:654/intervallo_pagine:643–654/volume:18

Background:Chalcones are considered as the selective scaffold for the inhibition of MAO-B.Objective:A previously synthesized ethyl acetohydroxamate-chalcones (L1-L22) were studied for their inhibitory activities against human recombinant monoamine ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fcc4df735cb653cc33b1da3ab2f805

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání