Výsledky vyhledávání - "Lays M Sobral"

Akademický článek

Proteomic approaches identify members of cofilin pathway involved in oral tumorigenesis.

Autor: Giovana M Polachini, Lays M Sobral, Ana M C Mercante, Adriana F Paes-Leme, Flávia C A Xavier, Tiago Henrique, Douglas M Guimarães, Alessandra Vidotto, Erica E Fukuyama, José F Góis-Filho, Patricia M Cury, Otávio A Curioni, Pedro Michaluart, Adriana M A Silva, Victor Wünsch-Filho, Fabio D Nunes, Andréia M Leopoldino, Eloiza H Tajara

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e50517 (2012)

The prediction of tumor behavior for patients with oral carcinomas remains a challenge for clinicians. The presence of lymph node metastasis is the most important prognostic factor but it is limited in predicting local relapse or survival. This highl

Externí odkaz: https://doaj.org/article/cc72c2d9fee04e0c94a08dfa74252918

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KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma

Autor: Joseph Hsieh, James C. Costello, Paul Jedlicka, Lays M. Sobral, Chelsea Self, Marybeth Sechler, Andrew Goodspeed, Janet K. Parrish, Kenneth L. Jones, Tyler S. McCann

Publikováno v: Oncotarget

Ewing sarcoma is an aggressive malignant neoplasm with high propensity for metastasis and poor clinical outcomes. The EWS/Fli1 oncofusion is the disease driver in > 90% of cases, but presents a difficult therapeutic target. Moreover, EWS/Fli1 plays a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6caf11a33b941f0c419e1904cd8f11
https://doi.org/10.18632/oncotarget.27737

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KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1‐driven and independent disease‐promoting gene expression in fusion‐positive Rhabdomyosarcoma

Autor: Tyler S. McCann, Joseph Hsieh, James C. Costello, Paul Jedlicka, Andrew Goodspeed, Lays M. Sobral, Janet K. Parrish, Hannah M. Hicks, Joshua C. Black

Publikováno v: Molecular Oncology, Vol 14, Iss 10, Pp 2471-2486 (2020)
Molecular Oncology

Fusion‐positive rhabdomyosarcoma (FP‐RMS) is an aggressive pediatric cancer. The chromatin factor KDM3A and the downstream transcription factor Ets1 comprise a new epigenetic axis that works together with, as well as independently of, the driver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3674546719b87787a0cc9743b1868ee7
https://doi.org/10.1002/1878-0261.12769

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KDM3A/Ets1/MCAM axis promotes growth and metastatic properties in Rhabdomyosarcoma

Autor: Janet K. Parrish, Kenneth L. Jones, Tyler S. McCann, Paul Jedlicka, Joshua C. Black, Marybeth Sechler, Lays M. Sobral

Publikováno v: Genes & Cancer

Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy of childhood. RMS exists as two major disease subtypes, with oncofusion-positive RMS (FP-RMS) typically carrying a worse prognosis than oncofusion-negative RMS (FN-RMS), in part due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c88b0181c4c1b6dcfa65ea6bad98101
https://pubmed.ncbi.nlm.nih.gov/32577157

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SET protein modulates H4 histone methylation status and regulates miR-137 level in oral squamous cell carcinoma

Autor: Lays M. Sobral, Lewis J. Greene, Luciana O. Almeida, Cristiana Bernadelli Garcia, Andréia Machado Leopoldino, Lucas Oliveira Sousa

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Aim: Histone acetylation and methylation control gene expression. We investigated the impact of SET knockdown on histone methylation status and the consequences for the miRNAs levels in oral squamous cell carcinoma (OSCC). Methods: OSCC cells with an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3209407bfbe0e273572c887ea8ae2cc6

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Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma

Autor: Michael P. Vitek, Gabriel da Silva, Andréia Machado Leopoldino, Lays M. Sobral, Renata Nishida Goto, Cristiana Bernadelli Garcia, Karina Stringhetta-Padovani

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

As SET protein is overexpressed and PP2A activity is reduced in oral squamous cell carcinoma (OSCC), this study aimed to assess the effects induced by OP449, a PP2A activator/SET inhibitor, on OSCC cells in vitro, and its potential either isolated or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4ed5be281e9f864bbdd751226a4ed0

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The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth

Autor: Tyler S. McCann, Paul Jedlicka, Kenneth L. Jones, Janet K. Parrish, Aik Choon Tan, Marybeth Sechler, Lays M. Sobral, Wen Hua Ren

Publikováno v: Oncotarget. 9:33110-33123

Ewing Sarcoma is an aggressive malignant neoplasm affecting children and young adults. Ewing Sarcoma is driven by transcription factor fusion oncoproteins, most commonly EWS/Fli1. While some patients can be cured with high-dose, multi-agent, chemothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52e508af4db8d3446fb76ca126c3f54
https://doi.org/10.18632/oncotarget.26011

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Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma

Autor: Andréia Machado Leopoldino, Estael Ochoa-Rodríguez, Lucas Oliveira Sousa, Norberto Peporine Lopes, Carlos Curti, Gilberto L. Pardo-Andreu, Javier Marín-Prida, Lays M. Sobral, Renata Nishida Goto, Cristiana Bernadelli Garcia, Yamila Verdecia-Reyes

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

This study aims to examine the effects of a new 1,4-dihydropyridine derivative, VdiE-2N, on cell signaling pathways and mitochondrial events in head and neck squamous cell carcinoma (HNSCC) cells, and on a mice model of xenograft tumor growth/cell pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20bb66314cf7246d5630949f3df7c64
https://doi.org/10.1016/j.ejphar.2017.12.009

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Relevance of CCL3/CCR5 axis in oral carcinogenesis

Autor: Aline Carvalho Batista, Celso Martins Queiroz-Junior, Andréia Machado Leopoldino, Janine Mayra da Silva, Mauro M. Teixeira, Lays M. Sobral, Remo Castro Russo, Milene Alvarenga Rachid, Tálita Pollyanna Moreira dos Santos, Amanda E. I. Proudfoot, Tarcília Aparecida Silva, Gustavo Pompermaier Garlet

Publikováno v: Oncotarget
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The chemokine CCL3 is a chemotactic cytokine crucial for inflammatory cell recruitment in homeostatic and pathological conditions. CCL3 might stimulate cancer progression by promoting leukocyte accumulation, angiogenesis and tumour growth. The expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6eedf6d41d60486ef97c118c84c4537
https://doi.org/10.18632/oncotarget.16882

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Lymph node or perineural invasion is associated with low miR-15a, miR-34c and miR-199b levels in head and neck squamous cell carcinoma

Autor: Rodrigo Alexandre Panepucci, Camila S. Matsumoto, Wilson A. Silva, Rossana Verónica Mendoza López, Lewis J. Greene, Carlos Curti, Fabiano Pinto Saggioro, Andréia Machado Leopoldino, Lucas Oliveira Sousa, Lays M. Sobral

Publikováno v: BBA Clinical
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background MicroRNAs (miRNAs or miRs) are post-transcriptional regulators of eukaryotic cells and knowledge of differences in miR levels may provide new approaches to diagnosis and therapy. Methods The present study measured the levels of nine miRs i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d58969399f97007516528dbb629e5de

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