The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome.

Autor: Xicota L; Sergievsky Center, Taub Institute, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Dang LT; Sergievsky Center, Taub Institute, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Lee A; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Krinsky-McHale S; Department of Psychology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA., Pang D; Department of Psychology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA., Melilli L; Sergievsky Center, Taub Institute, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., O'Bryant S; Institute of Translational Research, University of North Texas Health Sciences Center, Fort Worth, TX, USA., Henson RL; Department of Neurology, Washington University in St. Louis, St. Louis, MO., Laymon C; Departments of Radiology and Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA., Lai F; Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Rosas HD; Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Ances B; Department of Neurology, Washington University in St. Louis, St. Louis, MO., Lott I; Department of Neurology, UC Irvine, Irvine, CA, USA., Hom C; Department of Neurology, UC Irvine, Irvine, CA, USA., Christian B; Waisman Center and Department of Human Development and Family Studies, University of Wisconsin-Madison, Madison, WI, USA., Hartley S; Waisman Center and Department of Human Development and Family Studies, University of Wisconsin-Madison, Madison, WI, USA., Zaman S; Department of Psychiatry, University of Cambridge, Cambridge, UK., Head E; Department of Pathology & Laboratory Medicine and Department of Neurology, UC Irvine, Irvine, CA, USA., Mapstone M; Department of Neurology, UC Irvine, Irvine, CA, USA., Jin Z; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA., Silverman W; Department of Neurology, UC Irvine, Irvine, CA, USA., Schupf N; Sergievsky Center, Taub Institute, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Handen B; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Lee JH; Sergievsky Center, Taub Institute, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address: JHL2@cumc.columbia.edu.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Nov 04; Vol. 110, pp. 105433. Date of Electronic Publication: 2024 Nov 04.

AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome.

Autor: Hartley SL; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; School of Human Ecology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Handen B; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Tudorascu D; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Lee L; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Cohen A; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Schworer EK; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Peven JC; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Zammit M; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA., Klunk W; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Laymon C; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Minhas D; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Luo W; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Zaman S; Department of Psychiatry, University of Cambridge, Cambridge, UK., Ances B; Department of Neurology, Washington University at St. Louis, St. Louis, Missouri, USA., Preboske G; Mayo Clinic, Rochester, Minnesota, USA., Christian BT; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jan; Vol. 20 (1), pp. 366-375. Date of Electronic Publication: 2023 Aug 28.

Weight Loss and Alzheimer's Disease in Down Syndrome.

Autor: Fleming V; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; School of Human Ecology, University of Wisconsin-Madison, WI, USA., Helsel BC; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA., Ptomey LT; Departmentof Internal Medicine, University of Kansas Medical Center, KansasCity, KS, USA., Rosas HD; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Handen B; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Laymon C; Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA., Christian BT; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA., Head E; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, USA., Mapstone M; Department of Neurology, University of California Irvine, Irvine, CA, USA., Lai F; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, USA.; Department of Pediatrics, University of California Irvine, Irvine, CA, USA., Krinsky-McHale S; Department of Psychology, New York Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA., Zaman S; Department of Psychiatry, Clinical School, University of Cambridge, Cambridge, UK & Cambridgeshire and Peterborough Foundation NHS Trust, Cambridge, UK., Ances BM; Department of Neurology, Washington University Saint Louis, St. Louis, MO, USA., Lee JH; Departments of Neurology and Epidemiology, Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Hartley SL; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; School of Human Ecology, University of Wisconsin-Madison, WI, USA.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 91 (3), pp. 1215-1227.

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Role of tau deposition in early cognitive decline in Down syndrome.

Autor: Hartley SL; Waisman Center University of Wisconsin-Madison Madison Wisconsin USA.; School of Human Ecology University of Wisconsin-Madison Madison Wisconsin USA., Handen BL; Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA., Tudorascu D; Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA., Lee L; Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA., Cohen A; Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA., Piro-Gambetti B; Waisman Center University of Wisconsin-Madison Madison Wisconsin USA.; School of Human Ecology University of Wisconsin-Madison Madison Wisconsin USA., Zammit M; Waisman Center University of Wisconsin-Madison Madison Wisconsin USA.; Department of Medical Physics University of Wisconsin-Madison Madison Wisconsin USA., Klunk W; Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA., Laymon C; Department of Radiology and Bioengineering University of Pittsburgh Pittsburgh Pennsylvania USA., Zaman S; Department of Psychiatry University of Cambridge Cambridge UK., Ances BM; Department of Neurology Washington University at St. Louis St. Louis Missouri USA., Sabbagh M; Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas Nevada USA., Christian BT; Waisman Center University of Wisconsin-Madison Madison Wisconsin USA.; Department of Medical Physics University of Wisconsin-Madison Madison Wisconsin USA.

Publikováno v: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2022 Apr 01; Vol. 14 (1), pp. e12256. Date of Electronic Publication: 2022 Apr 01 (Print Publication: 2022).