A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome

Autor: Elena G. Bochukova, Katherine Lawler, Sophie Croizier, Julia M. Keogh, Nisha Patel, Garth Strohbehn, Kitty K. Lo, Jack Humphrey, Anita Hokken-Koelega, Layla Damen, Stephany Donze, Sebastien G. Bouret, Vincent Plagnol, I. Sadaf Farooqi

Publikováno v: Cell Reports, Vol 22, Iss 13, Pp 3401-3408 (2018)

Summary: Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome

Externí odkaz: https://doaj.org/article/4798546d39bd4dc69ff2ac49075ed378

Bone mineral density during 3 years of growth hormone in previously GH-treated young adults with PWS

Autor: Lionne N Grootjen, Stephany Donze, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega, Janiëlle A E M van der Velden, Layla Damen

Publikováno v: European Journal of Endocrinology, 184, 6, pp. 773-782
European Journal of Endocrinology, 184(6), 773-782. Bioscientifica Ltd
European Journal of Endocrinology, 184, 773-782

Objective In children with Prader–Willi syndrome (PWS), growth hormone (GH) treatment has positive effects on bone mineral density (BMD). Two 1-year studies did not show a difference between GH or placebo on BMD in young adults with PWS. However, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0b8f981b94afeefb03cd98151bd4a8
https://hdl.handle.net/2066/237282

Free Insulin-like Growth Factor (IGF)-I in Children with PWS

Autor: Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega

Publikováno v: Journal of Clinical Medicine, 11(5):1280. Multidisciplinary Digital Publishing Institute (MDPI)
Journal of Clinical Medicine; Volume 11; Issue 5; Pages: 1280

In children with Prader–Willi syndrome (PWS), the standard growth hormone (GH) dose often results in high immunoreactive IGF-I levels. These high immunoreactive IGF-I levels lead to concern because their long-term effects are unknown. As a result,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9b40a91218dedde5607075301f8f0a
https://doi.org/10.3390/jcm11051280

Prevalence of growth hormone (GH) deficiency in previously GH-treated young adults with Prader-Willi syndrome

Autor: Gera Hoorweg-Nijman, Anita C. S. Hokken-Koelega, Martijn J. J. Finken, Mariette van Leeuwen, Stephany Donze, Gianni Bocca, Petr E. Jira, Janiëlle A E M van Alfen-van der Velden, Layla Damen

Publikováno v: Clinical Endocrinology, 91(1), 118-123. Wiley
Clinical Endocrinology, 91, 118-123
Clinical Endocrinology, 91, 1, pp. 118-123
Clinical Endocrinology, 91(1), 118-123. Wiley-Blackwell Publishing Ltd
Donze, S H, Damen, L, van Alfen-van der Velden, J A E M, Bocca, G, Finken, M J J, Hoorweg-Nijman, G J G, Jira, P E, van Leeuwen, M & Hokken-Koelega, A C S 2019, ' Prevalence of growth hormone (GH) deficiency in previously GH-treated young adults with Prader-Willi syndrome ', Clinical Endocrinology, vol. 91, no. 1, pp. 118-123 . https://doi.org/10.1111/cen.13988
Clinical Endocrinology
Clinical Endocrinology, 91(1), 118-123. Wiley-Blackwell

OBJECTIVE: Some features of subjects with Prader-Willi syndrome (PWS) resemble those seen in growth hormone deficiency (GHD). Children with PWS are treated with growth hormone (GH), which has substantially changed their phenotype. Currently, young ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552835ff4798d883669ccbafe26dea8a
https://hdl.handle.net/2066/204782

Long-term cortisol levels in hair of children and adolescents with Prader-Willi Syndrome

Autor: Lionne N Grootjen, Anita C. S. Hokken-Koelega, Stephany Donze, Layla Damen

Publikováno v: Psychoneuroendocrinology, 132:105335. Elsevier Ltd.

Context: Prader-Willi syndrome (PWS) is characterized by hypothalamic dysfunction. In children with PWS, stress-induced central adrenal insufficiency (CAI) has been described, however, daily life cortisol production may be normal. Hair cortisol conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01a3dc30ba4a54a0df7cc05226e7e14
https://pubmed.ncbi.nlm.nih.gov/34225184