Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Layka Abbasi Asbagh"'
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Akademický článek
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination
Autor: Maria Francesca Baietti, Michal Simicek, Layka Abbasi Asbagh, Enrico Radaelli, Sam Lievens, Jonathan Crowther, Mikhail Steklov, Vasily N Aushev, David Martínez García, Jan Tavernier, Anna A Sablina
Publikováno v: EMBO Molecular Medicine, Vol 8, Iss 3, Pp 288-303 (2016)
Abstract Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggest
Externí odkaz: https://doaj.org/article/79e265d8964a42cface67fb45542386d
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Supplementary Figures from Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth
Autor: Veerle Janssens, Anna Sablina, Etienne Waelkens, Frédéric Amant, Yana Hoorne, Stefanie Schrauwen, Antoine Hubert, Rita Derua, Layka Abbasi Asbagh, Dorien Haesen
Supplemental Figure 1: Cellular binding assays in HEK293 cells, assessing binding of B55/B, B56/B' and PR72/B" subunits to endometrial cancer-associated Aα mutants. Supplemental Figure 2: Comparative analysis of binding of Aα mutants and endoge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e859019850b82966863ff59b59eb23
https://doi.org/10.1158/0008-5472.22413384.v1
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Data from Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth
Autor: Veerle Janssens, Anna Sablina, Etienne Waelkens, Frédéric Amant, Yana Hoorne, Stefanie Schrauwen, Antoine Hubert, Rita Derua, Layka Abbasi Asbagh, Dorien Haesen
Somatic missense mutations in the Ser/Thr protein phosphatase 2A (PP2A) Aα scaffold subunit gene PPP2R1A are among the few genomic alterations that occur frequently in serous endometrial carcinoma (EC) and carcinosarcoma, two clinically aggressive s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33dbb00a02b664035625ff9c6edc8fc1
https://doi.org/10.1158/0008-5472.c.6508701.v1
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Data from p16INK4a Impairs Homologous Recombination–Mediated DNA Repair in Human Papillomavirus–Positive Head and Neck Tumors
Autor: Sandra Nuyts, Anna Sablina, Esther Hauben, Iria Vázquez, Layka Abbasi Asbagh, Evert Jan Van Limbergen, Peter Kalev, Rüveyda Dok
The p16INK4a protein is a principal cyclin-dependent kinase inhibitor that decelerates the cell cycle. Abnormally high levels of p16INK4a are commonly observed in human papillomavirus (HPV)–positive head and neck squamous cell carcinomas (HNSCC). W
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df30b5151cf5430d83ae47bcb183162
https://doi.org/10.1158/0008-5472.c.6505676
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10
Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism
Autor: Jonas Dehairs, Tibor J. Pastor, Magdalena De Troyer, Johannes V. Swinnen, Layka Abbasi Asbagh, Anna Sablina, Iria Vazquez, Fabrizio Renzi, Maria Francesca Baietti, Jonathan Crowther, Yanyan Cai, Ali Talebi
Publikováno v: Cancer Cell. 29:751-766
Large-scale heterozygous deletions are a hallmark of cancer genomes. The concomitant loss of multiple genes creates vulnerabilities that are impossible to reveal through the study of individual genes. To delineate the functional outcome of chromosome
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748837aba7668bb9258c21444d5882e5
https://doi.org/10.1016/j.ccell.2016.04.003
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