Vitamin D-VDR signaling inhibits Wnt/beta-catenin-mediated melanoma progression and promotes anti-tumor immunity

Autor: Muralidhar, S, Filia, A, Nsengimana, J, Pozniak, J, O'Shea, SJ, Diaz, JM, Harland, M, Randerson-Moor, JA, Reichrath, J, Laye, JP, van der Weyden, L, Adams, DJ, Bishop, DT, Newton-Bishop, J

1α,25-dihydroxyvitamin D3 signals via the Vitamin D Receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As melanoma patients commonly avoid sun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::9ea8d8de776eb9afe72826610c9b9abe
https://eprints.whiterose.ac.uk/150850/1/Accepted_sept2019.pdf

Tumour infiltrating lymphocytes and survival after adjuvant chemotherapy in patients with gastric cancer: post-hoc analysis of the CLASSIC trial.

Autor: Liu DHW; Department of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands.; Institute of Clinical Pathology and Molecular Pathology, Kepler University Hospital and Johannes Kepler University, Linz, Austria., Kim YW; Department of Cancer Policy and Population Health, National Cancer Center Graduate School of Cancer Science and Policy and Center for Gastric Cancer and Department of Surgery, National Cancer Center, Goyang, Republic of Korea., Sefcovicova N; Department of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands., Laye JP; Pathology and Data Analytics, Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK., Hewitt LC; Department of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands.; Department of Precision Medicine, GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands., Irvine AF; Pathology and Data Analytics, Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK., Vromen V; Department of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands.; Cicero Zorgroep, Zuid-Limburg, The Netherlands., Janssen Y; Department of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands., Davarzani N; Department of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands., Fazzi GE; Department of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands., Jolani S; Department of Methodology and Statistics, CAPHRI, Maastricht University, Maastricht, Netherlands., Melotte V; Department of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands.; Department of Clinical Genetics, University of Rotterdam, Erasmus University Medical Center, Rotterdam, The Netherlands., Magee DR; School of Computing, University of Leeds, Leeds, UK.; HeteroGenius Limited, Leeds, UK., Kook MC; Center for Gastric Cancer, Department of Pathology, National Cancer Center, Goyang, Republic of Korea., Kim H; Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea., Langer R; Institute of Clinical Pathology and Molecular Pathology, Kepler University Hospital and Johannes Kepler University, Linz, Austria., Cheong JH; Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. jhcheong@yuhs.ac.; Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, Republic of Korea. jhcheong@yuhs.ac.; Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea. jhcheong@yuhs.ac., Grabsch HI; Department of Pathology, GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands. h.grabsch@maastrichtuniversity.nl.; Pathology and Data Analytics, Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK. h.grabsch@maastrichtuniversity.nl.

Publikováno v: British journal of cancer [Br J Cancer] 2023 Jun; Vol. 128 (12), pp. 2318-2325. Date of Electronic Publication: 2023 Apr 07.

Transcriptomic Analysis Reveals Prognostic Molecular Signatures of Stage I Melanoma.

Autor: Thakur R; University of Leeds School of Medicine, Leeds, United Kingdom.; Department of Surgical Oncology, MD Anderson Cancer Center, Houston, Texas., Laye JP; University of Leeds School of Medicine, Leeds, United Kingdom., Lauss M; Division of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden., Diaz JMS; University of Leeds School of Medicine, Leeds, United Kingdom., O'Shea SJ; Mater Private Hospital Cork, Mahon, Cork, Ireland.; School of Medicine, University College Cork, Cork, Ireland., Poźniak J; University of Leeds School of Medicine, Leeds, United Kingdom.; Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Filia A; Centre for Translational Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece., Harland M; University of Leeds School of Medicine, Leeds, United Kingdom., Gascoyne J; University of Leeds School of Medicine, Leeds, United Kingdom., Randerson-Moor JA; University of Leeds School of Medicine, Leeds, United Kingdom., Chan M; University of Leeds School of Medicine, Leeds, United Kingdom., Mell T; University of Leeds School of Medicine, Leeds, United Kingdom., Jönsson G; Division of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden., Bishop DT; University of Leeds School of Medicine, Leeds, United Kingdom., Newton-Bishop J; University of Leeds School of Medicine, Leeds, United Kingdom., Barrett JH; University of Leeds School of Medicine, Leeds, United Kingdom., Nsengimana J; University of Leeds School of Medicine, Leeds, United Kingdom. J.Nsengimana@leeds.ac.uk.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2019 Dec 15; Vol. 25 (24), pp. 7424-7435. Date of Electronic Publication: 2019 Sep 12.

Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma.

Autor: Poźniak J; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom. joanna.m.pozniak@gmail.com., Nsengimana J; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom., Laye JP; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom., O'Shea SJ; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom.; Faculty of Medicine and Health, University College Cork, Cork, Ireland.; Mater Private Hospital Cork, Citygate, Mahon, Cork, Ireland., Diaz JMS; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom., Droop AP; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom.; Medical Research Council (MRC) Medical Bioinformatics Centre, University of Leeds, Leeds, United Kingdom., Filia A; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom.; Centre for Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Harland M; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom., Davies JR; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom., Mell T; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom., Randerson-Moor JA; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom., Muralidhar S; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom., Hogan SA; Department of Dermatology, University of Zürich Hospital, University of Zürich, Zürich, Switzerland., Freiberger SN; Department of Dermatology, University of Zürich Hospital, University of Zürich, Zürich, Switzerland., Levesque MP; Department of Dermatology, University of Zürich Hospital, University of Zürich, Zürich, Switzerland., Cook GP; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom., Bishop DT; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom., Newton-Bishop J; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom.

Publikováno v: Cancer research [Cancer Res] 2019 May 15; Vol. 79 (10), pp. 2684-2696. Date of Electronic Publication: 2019 Feb 17.

SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity.

Autor: Care MA; Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK Bioinformatics Group, School of Molecular and Cellular Biology, University of Leeds, Leeds, UK., Cocco M; Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK., Laye JP; Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK., Barnes N; Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK., Huang Y; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK., Wang M; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK., Barrans S; Haematological Malignancy Diagnostic Service, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Du M; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK., Jack A; Haematological Malignancy Diagnostic Service, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Westhead DR; Bioinformatics Group, School of Molecular and Cellular Biology, University of Leeds, Leeds, UK., Doody GM; Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK., Tooze RM; Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK Haematological Malignancy Diagnostic Service, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK r.tooze@leeds.ac.uk.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2014 Jul; Vol. 42 (12), pp. 7591-610. Date of Electronic Publication: 2014 May 29.