In vivo photopharmacology with light-activated opioid drugs.

Autor: McClain SP; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA; Neurosciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA., Ma X; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA., Johnson DA; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA., Johnson CA; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA., Layden AE; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA., Yung JC; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA., Lubejko ST; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA; Neurosciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA., Livrizzi G; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA; Biological Sciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA., He XJ; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA; Biological Sciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA., Zhou J; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA., Chang-Weinberg J; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA., Ventriglia E; Biobehavioral Imaging and Molecular, Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA., Rizzo A; Departament de Patologia i Terapèutica Experimental, Institut de Neurociències, Universitat de Barcelona, L'Hospitalet de Llobregat 08907, Catalonia, Spain; Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, L'Hospitalet de Llobregat 08907, Catalonia, Spain., Levinstein M; Biobehavioral Imaging and Molecular, Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA., Gomez JL; Biobehavioral Imaging and Molecular, Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA., Bonaventura J; Departament de Patologia i Terapèutica Experimental, Institut de Neurociències, Universitat de Barcelona, L'Hospitalet de Llobregat 08907, Catalonia, Spain; Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, L'Hospitalet de Llobregat 08907, Catalonia, Spain., Michaelides M; Biobehavioral Imaging and Molecular, Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA., Banghart MR; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: mbanghart@ucsd.edu.

Publikováno v: Neuron [Neuron] 2023 Dec 20; Vol. 111 (24), pp. 3926-3940.e10. Date of Electronic Publication: 2023 Oct 16.

In vivo photopharmacology with a caged mu opioid receptor agonist drives rapid changes in behavior.

Autor: Ma X; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA., Johnson DA; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA., He XJ; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA., Layden AE; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA., McClain SP; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA., Yung JC; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA., Rizzo A; Departament de Patologia i Terapèutica Experimental, Institut de Neurociències, Universitat de Barcelona, L'Hospitalet de Llobregat, Catalonia, Spain.; Neuropharmacology and Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Catalonia, Spain., Bonaventura J; Departament de Patologia i Terapèutica Experimental, Institut de Neurociències, Universitat de Barcelona, L'Hospitalet de Llobregat, Catalonia, Spain.; Neuropharmacology and Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, Catalonia, Spain., Banghart MR; Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA. mbanghart@ucsd.edu.

Publikováno v: Nature methods [Nat Methods] 2023 May; Vol. 20 (5), pp. 682-685. Date of Electronic Publication: 2023 Mar 27.