Výsledky vyhledávání - "Laychiluh Mekonnen"

Akademický článek

Discovery of N,4-Di(1H-pyrazol-4-yl)pyrimidin-2-amine-Derived CDK2 Inhibitors as Potential Anticancer Agents: Design, Synthesis, and Evaluation

Autor: Biruk Sintayehu Fanta, Jimma Lenjisa, Theodosia Teo, Lianmeng Kou, Laychiluh Mekonnen, Yuchao Yang, Sunita K. C. Basnet, Ramin Hassankhani, Matthew J. Sykes, Mingfeng Yu, Shudong Wang

Publikováno v: Molecules, Vol 28, Iss 7, p 2951 (2023)

Cyclin-dependent kinase 2 (CDK2) has been garnering considerable interest as a target to develop new cancer treatments and to ameliorate resistance to CDK4/6 inhibitors. However, a selective CDK2 inhibitor has yet to be clinically approved. With the

Externí odkaz: https://doaj.org/article/e7f7255ec5e440348ed681432266d49d

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Discovery of Potent Inhibitors of Cyclin-Dependent Kinases 7 and 9: Design, Synthesis, Structure-Activity Relationship Analysis and Biological Evaluation

Autor: Renjie Chen, Ramin Hassankhani, Yi Long, Sunita K. C. Basnet, Theodosia Teo, Yuchao Yang, Laychiluh Mekonnen, Mingfeng Yu, Shudong Wang

Publikováno v: ChemMedChem.

Cyclin-dependent kinases (CDKs) 7 and 9 are deregulated in various types of human cancer and are thus viewed as therapeutic targets. Accordingly, small-molecule inhibitors of both CDKs are highly sought-after. Capitalising on our previous discovery o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83191a927e012c62f7945736ad5349a5
https://pubmed.ncbi.nlm.nih.gov/36400715

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Kinase inhibitors: Opportunities for small molecule anticancer immunotherapies

Autor: Ava Safaroghli-Azar, Fatemeh Emadi, Jimma Lenjisa, Laychiluh Mekonnen, Shudong Wang

Publikováno v: Drug Discovery Today. 28:103525

Refereed/Peer-reviewed As the fifth pillar of cancer treatment, immunotherapy has dramatically changed the paradigm of therapeutic strategies by focusing on the host’s immune system. In the long road of immunotherapy development, the identification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddbbd3b369fa3de2c1d97d2304852ed
https://doi.org/10.1016/j.drudis.2023.103525

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Discovery of Novel and Potent Inhibitors of Cyclin-Dependent Kinases 7 and 9: Design, Synthesis, Structure-Activity Relationship Analysis and Biological Evaluation

Autor: Renjie Chen, Ramin Hassankhani, Yi Long, Sunita K. C. Basnet, Theodosia Teo, Yuchao Yang, Laychiluh Mekonnen, Mingfeng Yu, Shudong Wang

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bff383b48c8ea188b59eff5326d6c2f3
https://doi.org/10.2139/ssrn.4210989

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2-Anilino-4-(1-methyl-1H-pyrazol-4-yl)pyrimidine-derived CDK2 inhibitors as anticancer agents: Design, synthesis & evaluation

Autor: Biruk Sintayehu Fanta, Laychiluh Mekonnen, Sunita K.C. Basnet, Theodosia Teo, Jimma Lenjisa, Nishat Z. Khair, Lianmeng Kou, Solomon Tadesse, Matthew J. Sykes, Mingfeng Yu, Shudong Wang

Publikováno v: Bioorganic & Medicinal Chemistry. 80:117158

Refereed/Peer-reviewed Deregulation of cyclin-dependent kinase 2 (CDK2) and its activating partners, cyclins A and E, is associated with the pathogenesis of a myriad of human cancers and with resistance to anticancer drugs including CDK4/6 inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8f63a551dceced78f485f06da01662
https://doi.org/10.1016/j.bmc.2023.117158

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