Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Laychiluh B. Mekonnen"'
Autor:
Shudong Wang, Mingfeng Yu, Robert W. Milne, Cobus Gerber, Benjamin Noll, Saiful Islam, Sunita K.C. Basnet, Hugo Albrecht, Jingfeng Lu, Sarah Diab, Peng Li, Ahmed Abdelaziz, Laychiluh B. Mekonnen
Publikováno v:
Medicinal Chemistry. 15:602-623
Background:Aberrant expression of eukaryotic translation initiation factor 4E (eIF4E) is common in many types of cancer including acute myeloid leukaemia (AML). Phosphorylation of eIF4E by MAPK-interacting kinases (Mnks) is essential for the eIF4E-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78300ef209a34b429c837abbbb93df57
https://doi.org/10.2174/1573406415666181219111511
https://doi.org/10.2174/1573406415666181219111511
Autor:
Mingfeng Yu, Shudong Wang, Jimma L Lenjisa, Laychiluh B. Mekonnen, Solomon Tadesse, Michael P. Brown, Ge Zhu
Publikováno v:
Future Medicinal Chemistry. 9:1495-1506
Aim: Inhibitors of CDK4/6 have emerged as a powerful class of therapeutics for treatment of several malignancies. We herein describe the identification of a new series of molecules that demonstrated excellent selectivity for CDK4/6 over CDKs1, 7 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4d0eec8491df82e3ecd1d6a6a21462
https://doi.org/10.4155/fmc-2017-0076
https://doi.org/10.4155/fmc-2017-0076
Autor:
Muhammed H. Rahaman, Shudong Wang, Solomon Tadesse, Khamis Tomusange, Robert W. Milne, Laychiluh B. Mekonnen, Saiful Islam, Frankie Lam, Benjamin Noll, Hugo Albrecht, Sunita K.C. Basnet, Mingfeng Yu, Theodosia Teo
Publikováno v:
Journal of Medicinal Chemistry. 60:1892-1915
Cyclin D dependent kinases (CDK4 and CDK6) regulate entry into S phase of the cell cycle and are validated targets for anticancer drug discovery. Herein we detail the discovery of a novel series of 4-thiazol-N-(pyridin-2-yl)pyrimidin-2-amine derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1648237e2f97eba5963718c7cb65e8c3
https://doi.org/10.1021/acs.jmedchem.6b01670
https://doi.org/10.1021/acs.jmedchem.6b01670
Autor:
Hugo Albrecht, Solomon Tadesse, Matthew J. Sykes, Nishat Zareen Khair, Shudong Wang, Malika Kumarasiri, Jimma L Lenjisa, Robert W. Milne, Laychiluh B. Mekonnen, Sarah Diab, Man-jun Li, Sunita K.C. Basnet
Publikováno v:
ACS Med Chem Lett
Specific abrogation of cyclin-dependent kinase 5 (CDK5) activity has been validated as a viable approach for the development of anticancer agents. However, no selective CDK5 inhibitor has been reported to date. Herein, a structure-based in silico scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683ff5cd65cd9dc6bcc6078b1453b846
https://europepmc.org/articles/PMC6511963/
https://europepmc.org/articles/PMC6511963/
Autor:
Muhammed H. Rahaman, John D. Hayball, Theodosia Teo, Stephen Philip, Laychiluh B. Mekonnen, Shudong Wang, Yi Long, Man-jun Li, Preethi Eldi, Mingfeng Yu, Benjamin Noll, Gary K. Heinemann, Yuchao Yang, Abel Tesfaye Anshabo, Robert W. Milne, Sarah Diab
Publikováno v:
European Journal of Medicinal Chemistry. 214:113248
CDK8 regulates transcription either by phosphorylation of transcription factors or, as part of a four-subunit kinase module, through a reversible association of the kinase module with the Mediator complex, a highly conserved transcriptional coactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9410b245d422cfbe104b9416c59eb800
https://doi.org/10.1016/j.ejmech.2021.113248
https://doi.org/10.1016/j.ejmech.2021.113248
Autor:
Solomon Zeleke, Gary K. Heinemann, Jimma L Lenjisa, Benjamin Noll, Hugo Albrecht, Robert W. Milne, Shudong Wang, Martin K. Oehler, Mingfeng Yu, Laychiluh B. Mekonnen
Publikováno v:
Cancer Research. 78:1524-1524
Ovarian cancer is one of the most common malignancies, accounting for more deaths than any other cancer of the female reproductive system. Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ace73212ecdfacca3d0f94988917545
https://doi.org/10.1158/1538-7445.am2018-1524
https://doi.org/10.1158/1538-7445.am2018-1524