Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice

Autor: Yue Li, Norihiro Imai, Hayley T. Nicholls, Blaine R. Roberts, Samaksh Goyal, Tibor I. Krisko, Lay-Hong Ang, Matthew C. Tillman, Anne M. Roberts, Mahnoor Baqai, Eric A. Ortlund, David E. Cohen, Susan J. Hagen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Cold exposure activates thermogenesis and fatty acid oxidation in brown fat, a process suppressed by Them1. Here, the authors show that cold induces Them1 phosphorylation and loss of puncta that suppress fatty acid use, leading to a diffuse localizat

Externí odkaz: https://doaj.org/article/e474110267a740bcbae71a2b1885f9cd

Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

Autor: Mee Rie Sheen, Jennifer L Fields, Brian Northan, Judith Lacoste, Lay-Hong Ang, Steven Fiering, Reproducibility Project: Cancer Biology

Publikováno v: eLife, Vol 8 (2019)

As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Fiering et al., 2015) that described how we intended to replicate selected experiments from the paper ‘Biomechanical remodeling of the microenvironment by stro

Externí odkaz: https://doaj.org/article/f7f00516500a4cbf83d0625514846ee2

Data from The L6 Protein TM4SF1 Is Critical for Endothelial Cell Function and Tumor Angiogenesis

Autor: Harold F. Dvorak, Lawrence F. Brown, Janice A. Nagy, Lay-Hong Ang, Guanmei Liu, Dan Li, Andrew Zukauskas, Shou-Ching Shih

Transmembrane-4-L-six-family-1 (TM4SF1) was originally described as a cancer cell protein. Here, we show that it is highly expressed in the vascular endothelium of human cancers and in a banded pattern in the filopodia of cultured endothelial cells (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49cf912f8286be5ff0ded7cde4e625e9
https://doi.org/10.1158/0008-5472.c.6499659.v1

Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial Cells

Autor: Mahnoor Baqai, James G. Fox, Susan J. Hagen, Nishita Sinha, Yue Li, Tyler J. Caron, Jerrold R. Turner, Sureshkumar Muthupalani, Lay-Hong Ang, Kathleen E Scott

Publikováno v: Elsevier
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 783-801 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Tight junctions form a barrier to the paracellular passage of luminal antigens. Although most tight junction proteins reside within the apical tight junction complex, claudin-18 localizes mainly to the basolateral membrane where its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fe29aeb8bf6cde834e2ffb0c105a3b
https://doi.org/10.1016/j.jcmgh.2020.10.005

Extracellular Hsp90α Detoxifies β-Amyloid Fibrils Through an NRF2 and Autophagy Dependent Pathway

Autor: Woodbury M, Benjamin J. Lang, Choudhury R, Ayesha Murshid, Stuart K. Calderwood, Thiago J Borges, Tsuneya Ikezu, Lay-Hong Ang, Yasmine S, Clark-Matott J, Doshi Sp, Yuka Okusha

We have investigated the role of extracellular Heat shock protein 90alpha (eHsp90α) in conferring protection of neuronal cells against fibrillary amyloid beta (f-Aβ1-42) toxicity mediated by microglial cells. Formation of f-Aβ1-42 plaques leads to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa79b89e74ad1fc4c63b1cf0bef25d48
https://doi.org/10.1101/2021.04.16.440151