Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Lay Keng Tan"'
Autor:
Kun Yu, Kumaresan Ganesan, Lay Keng Tan, Mirtha Laban, Jeanie Wu, Xiao Dong Zhao, Hongmin Li, Carol Ho Wing Leung, Yansong Zhu, Chia Lin Wei, Shing Chuan Hooi, Lance Miller, Patrick Tan
Publikováno v:
PLoS Genetics, Vol 4, Iss 7, p e1000129 (2008)
Successful tumor development and progression involves the complex interplay of both pro- and anti-oncogenic signaling pathways. Genetic components balancing these opposing activities are likely to require tight regulation, because even subtle alterat
Externí odkaz:
https://doaj.org/article/b616a2162972477597178fd5b4f9eef8
Autor:
Taotao Sheng, Shamaine Wei Ting Ho, Wen Fong Ooi, Chang Xu, Manjie Xing, Nisha Padmanabhan, Kie Kyon Huang, Lijia Ma, Mohana Ray, Yu Amanda Guo, Ngak Leng Sim, Chukwuemeka George Anene-Nzelu, Mei Mei Chang, Milad Razavi-Mohseni, Michael A. Beer, Roger Sik Yin Foo, Raghav Sundar, Yiong Huak Chan, Angie Lay Keng Tan, Xuewen Ong, Anders Jacobsen Skanderup, Kevin P. White, Sudhakar Jha, Patrick Tan
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-25 (2021)
Abstract Background Enhancers are distal cis-regulatory elements required for cell-specific gene expression and cell fate determination. In cancer, enhancer variation has been proposed as a major cause of inter-patient heterogeneity—however, most p
Externí odkaz:
https://doaj.org/article/38cedd9ca8014168bc07ffb9aa64af83
Autor:
Nisha Padmanabhan, Huang Kie Kyon, Arnoud Boot, Kevin Lim, Supriya Srivastava, Shuwen Chen, Zhiyuan Wu, Hyung-O K Lee, Vineeth T. Mukundan, Charlene Chan, Yarn Kit Chan, Ong Xuewen, Jason J. Pitt, Zul Fazreen Adam Isa, Manjie Xing, Ming Hui Lee, Angie Lay Keng Tan, Shamaine Ho Wei Ting, Micah A. Luftig, Dennis Kappei, Warren D. Kruger, Jinsong Bian, Ying Swan Ho, Ming Teh, Steve George Rozen, Patrick Tan
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-29 (2021)
Abstract Background CIMP (CpG island methylator phenotype) is an epigenetic molecular subtype, observed in multiple malignancies and associated with the epigenetic silencing of tumor suppressors. Currently, for most cancers including gastric cancer (
Externí odkaz:
https://doaj.org/article/9fe03d39024a4581867a3f4455dc22c4
Autor:
Kie Kyon Huang, Jiawen Huang, Jeanie Kar Leng Wu, Minghui Lee, Su Ting Tay, Vikrant Kumar, Kalpana Ramnarayanan, Nisha Padmanabhan, Chang Xu, Angie Lay Keng Tan, Charlene Chan, Dennis Kappei, Jonathan Göke, Patrick Tan
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Background Deregulated gene expression is a hallmark of cancer; however, most studies to date have analyzed short-read RNA sequencing data with inherent limitations. Here, we combine PacBio long-read isoform sequencing (Iso-Seq) and Illumina
Externí odkaz:
https://doaj.org/article/3769f999db7f45c5ba41d9dc617249e6
Autor:
Song Li, Chwee Tat Koe, Su Ting Tay, Angie Lay Keng Tan, Shenli Zhang, Yingjie Zhang, Patrick Tan, Wing-Kin Sung, Hongyan Wang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The spindle matrix proteins, including Chro, are known to regulate mitotic spindle assembly in the cytoplasm. Here the authors show that in Drosophila larval brain, Chro promotes neural stem cell (NSC) reactivation and prevents activated NSCs from en
Externí odkaz:
https://doaj.org/article/56bb01d0b76b4e4b9c7eb4cb6ffab76a
Autor:
Amrita M. Nargund, Chang Xu, Amit Mandoli, Atsushi Okabe, Gao Bin Chen, Kie Kyon Huang, Taotao Sheng, Xiaosai Yao, Jia Ming Nickolas Teo, Raghav Sundar, Yee Jiun Kok, Yi Xiang See, Manjie Xing, Zhimei Li, Chern Han Yong, Aparna Anand, Zul Fazreen Bin Adam Isa, Lai Fong Poon, Michelle Shu Wen Ng, Javier Yu Peng Koh, Wen Fong Ooi, Su Ting Tay, Xuewen Ong, Angie Lay Keng Tan, Duane T. Smoot, Hassan Ashktorab, Heike I. Grabsch, Melissa J. Fullwood, Bin Tean Teh, Xuezhi Bi, Atsushi Kaneda, Shang Li, Patrick Tan
Publikováno v:
Cancer Research, 82(14), 2538-2551. American Association for Cancer Research Inc.
Mutations in the DNA mismatch repair gene MSH2 are causative of microsatellite instability (MSI) in multiple cancers. Here, we discovered that besides its well-established role in DNA repair, MSH2 exerts a novel epigenomic function in gastric cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61c53230d73fbce325f23134840d4a1
https://doi.org/10.1158/0008-5472.can-21-2072
https://doi.org/10.1158/0008-5472.can-21-2072
Autor:
Shamaine Wei Ting Ho, Taotao Sheng, Manjie Xing, Wen Fong Ooi, Chang Xu, Raghav Sundar, Kie Kyon Huang, Zhimei Li, Vikrant Kumar, Kalpana Ramnarayanan, Feng Zhu, Supriya Srivastava, Zul Fazreen Bin Adam Isa, Chukwuemeka George Anene-Nzelu, Milad Razavi-Mohseni, Dustin Shigaki, Haoran Ma, Angie Lay Keng Tan, Xuewen Ong, Ming Hui Lee, Su Ting Tay, Yu Amanda Guo, Weitai Huang, Shang Li, Michael A. Beer, Roger Sik Yin Foo, Ming Teh, Anders Jacobsen Skanderup, Bin Tean Teh, Patrick Tan
Publikováno v:
Gut. 72:226-241
ObjectiveGastric cancer (GC) comprises multiple molecular subtypes. Recent studies have highlighted mesenchymal-subtype GC (Mes-GC) as a clinically aggressive subtype with few treatment options. Combining multiple studies, we derived and applied a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536a9a34164d590ade272669919f2bcb
https://doi.org/10.1136/gutjnl-2021-326483
https://doi.org/10.1136/gutjnl-2021-326483
Autor:
Kie Kyon Huang, Haoran Ma, Tomoyuki Uchihara, Taotao Sheng, Roxanne Hui Heng Chong, Feng Zhu, Supriya Srivastava, Su Ting Tay, Raghav Sundar, Angie Lay Keng Tan, Xuewen Ong, Minghui Lee, Shamaine Wei Ting Ho, Tom Lesluyes, Peter Van Loo, Joy Shijia Chua, Kalpana Ramnarayanan, Tiing Leong Ang, Christopher Khor, Jonathan Wei Jie Lee, Stephen Kin Kwok Tsao, Ming Teh, Hyunsoo Chung, Jimmy Bok Yan So, Khay Guan Yeoh, Patrick Tan, Singapore Gastric Cancer Consortium
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with increased gastric cancer (GC) risk. We analyzed 1256 gastric samples (1152 IMs) from 692 subjects through a prospective 10-year study. We identified 26 IM d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a3dd04b8a9b173e34125acc12d92ea
https://doi.org/10.1101/2023.04.10.536195
https://doi.org/10.1101/2023.04.10.536195
Autor:
Patrick Tan, Jimmy Bok Yan So, Wei Peng Yong, Ming Teh, Huey Yew Jeffrey Lum, Kong-Peng Lam, Shengli Xu, Biyan Zhang, Qingfeng Chen, Asim Shabbir, Guowei Kim, Takatsugu Ishimoto, Angie Lay Keng Tan, Shamaine Wei Ting Ho, Su Ting Tay, Kie Kyon Huang, Vivien Koh, Tadahito Yasuda, Mayu Koiwa, Supriya Srivastava, Nisha Padmanabhan, Raghav Sundar, Kalpana Ramnarayanan, Vikrant Kumar
Gastric cancer heterogeneity represents a barrier to disease management. We generated a comprehensive single-cell atlas of gastric cancer (>200,000 cells) comprising 48 samples from 31 patients across clinical stages and histologic subtypes. We ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933ffc56e0e6a3c0e3446453cd9e102e
https://doi.org/10.1158/2159-8290.c.6549613.v1
https://doi.org/10.1158/2159-8290.c.6549613.v1
Autor:
Patrick Tan, Jimmy Bok Yan So, Wei Peng Yong, Ming Teh, Huey Yew Jeffrey Lum, Kong-Peng Lam, Shengli Xu, Biyan Zhang, Qingfeng Chen, Asim Shabbir, Guowei Kim, Takatsugu Ishimoto, Angie Lay Keng Tan, Shamaine Wei Ting Ho, Su Ting Tay, Kie Kyon Huang, Vivien Koh, Tadahito Yasuda, Mayu Koiwa, Supriya Srivastava, Nisha Padmanabhan, Raghav Sundar, Kalpana Ramnarayanan, Vikrant Kumar
Supplementary Data from Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c138bf982558607d1cdca0dea4a776
https://doi.org/10.1158/2159-8290.22541323.v1
https://doi.org/10.1158/2159-8290.22541323.v1