Výsledky vyhledávání - "Laxmi Iyer Ravi"

Virus-induced activation of the rac1 protein at the site of respiratory syncytial virus assembly is a requirement for virus particle assembly on infected cells

Autor: Boon Huan Tan, Laxmi Iyer Ravi, Richard J. Sugrue, Timothy J. C. Tan

Publikováno v: Virology. 557:86-99

The distributions of the rac1, rhoA and cdc42 proteins in respiratory syncytial virus (RSV) infected cells was examined. All three rhoGTPases were detected within inclusion bodies, and while the rhoA and rac1 proteins were associated with virus filam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57051f3bd76d79cb561149fdf08ae3e
https://doi.org/10.1016/j.virol.2021.02.008

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Caveolae provide a specialized membrane environment for respiratory syncytial virus assembly

Autor: Sara Sandin, Tra Huong Nguyen, Laxmi Iyer Ravi, Alexander Ludwig, Daniel Leong, Boon Huan Tan, Richard J. Sugrue

Publikováno v: Journal of Cell Science

Respiratory syncytial virus (RSV) is an enveloped virus that assembles into filamentous virus particles on the surface of infected cells. Morphogenesis of RSV is dependent upon cholesterol-rich (lipid raft) membrane microdomains, but the specific rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a989ec9e4fd4d98c4f8639eec7a1fe1d
https://doi.org/10.1242/jcs.198853

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Increased hydroxymethylglutaryl coenzyme A reductase activity during respiratory syncytial virus infection mediates actin dependent inter-cellular virus transmission

Autor: Li Liang, Pui San Wong, Boon Huan Tan, Gaie Brown, Laxmi Iyer Ravi, Richard J. Sugrue

Publikováno v: Antiviral Research. 100:259-268

We have examined the role that hydroxymethylglutaryl coenzyme A reductase (HMGCR) plays during respiratory syncytial virus (RSV) maturation. Imaging analysis indicated that virus-induced changes in F-actin structure correlated with the formation of v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b05d37f8c440b702cd248d3bde769c3
https://doi.org/10.1016/j.antiviral.2013.08.012

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Lovastatin treatment mitigates the pro-inflammatory cytokine response in respiratory syncytial virus infected macrophage cells

Autor: Pui San Wong, Richard Sutejo, Boon Huan Tan, Liang Li, Richard J. Sugrue, Laxmi Iyer Ravi

Publikováno v: Antiviral Research. 98:332-343

Disease severity following respiratory syncytial virus (RSV) infection is associated with inflammation due to enhanced pro-inflammatory cytokine secretion, and lung macrophage cells play a role in this process. In this study we evaluated the hydroxym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de4f5f8434b2b53e08477c04981ff3c
https://doi.org/10.1016/j.antiviral.2013.03.015

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Evidence for a biphasic mode of respiratory syncytial virus transmission in permissive HEp2 cell monolayers

Autor: Richard J. Sugrue, Tra Nguyen Huong, Laxmi Iyer Ravi, Boon Huan Tan

Publikováno v: Virology Journal

Background During respiratory syncytial virus (RSV) infection filamentous virus particles are formed on the cell surface. Although the virus infectivity remains cell-associated, low levels of cell-free virus is detected during advanced infection. It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2c431bce3d1fe273611027246f7b96
https://doi.org/10.1186/s12985-016-0467-9

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Morphogenesis of respiratory syncytial virus in human primary nasal ciliated epithelial cells occurs at surface membrane microdomains that are distinct from cilia

Autor: Chun Wei Li, Puisan Wong, Yan Yan, Laxmi Iyer Ravi, De Yun Wang, Boon Huan Tan, Muhammad Raihan Jumat, Tra Nguyen Huong, Richard J. Sugrue

Publikováno v: Virology. 484

The distribution of cilia and the respiratory syncytial virus (RSV) nucleocapsid (N) protein, fusion (F) protein, attachment (G) protein, and M2-1 protein in human ciliated nasal epithelial cells was examined at between 1 and 5 days post-infection (d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67aaeebb534e663317f6028fb40200d6
https://pubmed.ncbi.nlm.nih.gov/26231613

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Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis

Autor: Tra Ngyen Huong, Richard J. Sugrue, Rebecca Rongrong Stanford, Boon Huan Tan, Laxmi Iyer Ravi, Muhammad Raihan Jumat

Publikováno v: Antiviral research. 114

We examined the effect of respiratory syncytial virus (RSV) infection on viperin protein expression in the permissive HEp2 and non-permissive RAW 264.7 macrophage cell lines. In RSV-infected HEp2 cells low levels of the viperin protein was localized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede239887bdd790c3f96c74b82e699f1
https://pubmed.ncbi.nlm.nih.gov/25433308

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A systems-based approach to analyse the host response in murine lung macrophages challenged with respiratory syncytial virus

Autor: Boon Huan Tan, Liang Li, Richard J. Sugrue, Pui San Wong, Laxmi Iyer Ravi, Richard Sutejo, Hui Chen

Publikováno v: BMC Genomics

Background Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in young children. The degree of disease severity is determined by the host response to infection. Lung macrophages play an important early role i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474240fbad28841f26ea8bea2de694ae
https://doi.org/10.1186/1471-2164-14-190

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