Hypomethylation and Aberrant Expression of the Glioma Pathogenesis-Related 1 Gene in Wilms Tumors

Autor: Laxmi Chilukamarri, Anne L. Hancock, Sally Malik, Joanna Zabkiewicz, Jenny A. Baker, Alexander Greenhough, Anthony R. Dallosso, Tim Hui-Ming Huang, Brigitte Royer-Pokora, Keith W. Brown, Karim Malik

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 11, Pp 970-978 (2007)

Wilms tumors (WTs) have a complex etiology, displaying genetic and epigenetic changes, including loss of imprinting (LOI) and tumor suppressor gene silencing. To identify new regions of epigenetic perturbation in WTs, we screened kidney and tumor DNA

Externí odkaz: https://doaj.org/article/21d16ee5da0347cb9bba27ed239044f5

Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor.

Autor: Anthony R Dallosso, Anne L Hancock, Marianna Szemes, Kim Moorwood, Laxmi Chilukamarri, Hsin-Hao Tsai, Abby Sarkar, Jonathan Barasch, Raisa Vuononvirta, Chris Jones, Kathy Pritchard-Jones, Brigitte Royer-Pokora, Sean Bong Lee, Ceris Owen, Sally Malik, Yi Feng, Marcus Frank, Andrew Ward, Keith W Brown, Karim Malik

Publikováno v: PLoS Genetics, Vol 5, Iss 11, p e1000745 (2009)

Wilms' tumour (WT) is a pediatric tumor of the kidney that arises via failure of the fetal developmental program. The absence of identifiable mutations in the majority of WTs suggests the frequent involvement of epigenetic aberrations in WT. We there

Externí odkaz: https://doaj.org/article/7af8fa26a11e4c70987e9295678bdc7f

Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor

Autor: Keith W. Brown, Karim Malik, Yi Feng, Marianna Szemes, Hsin-Hao Tsai, Jonathan Barasch, Anthony R. Dallosso, Andrew Ward, Laxmi Chilukamarri, Ceris Owen, Kathy Pritchard-Jones, Anne L. Hancock, Brigitte Royer-Pokora, Raisa Vuononvirta, Kim Moorwood, Sean Bong Lee, Abby Sarkar, Chris Jones, Marcus Frank, Sally Malik

Publikováno v: Dallosso, A R, Hancock, A L, Szemes, M, Moorwood, K, Chilukamarri, L, Tsai, H-H, Sarkar, A, Barasch, J, Vuononvirta, R, Jones, C, Pritchard-Jones, K, Royer-Pokora, B, Lee, S B, Owen, C, Malik, S, Feng, Y, Frank, M, Ward, A, Brown, K W & Malik, K 2009, ' Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor ', PLoS Genetics, vol. 5, no. 11, e1000745 . https://doi.org/10.1371/journal.pgen.1000745
PLOS GENET, 5 (11), Article e1000745. (2009)
PLoS Genetics
Dallosso, A R, Hancock, A L, Szemes, M, Moorwood, K, Chilukamarri, L, Tsai, H H, Sarkar, A, Barasch, J, Vuononvirta, R, Jones, C, Pritchard-Jones, K, Royer-Pokora, B, Lee, S B, Owen, C, Malik, S, Feng, Y, Frank, M, Ward, A, Brown, K W & Malik, K 2009, ' Frequent long-range epigenetic silencing of Protocadherin gene clusters on chromosome 5q31 in Wilms' Tumor ', Plos Genetics, vol. 5, no. 11, e1000745 . https://doi.org/10.1371/journal.pgen.1000745
PLoS Genetics, Vol 5, Iss 11, p e1000745 (2009)

Wilms' tumour (WT) is a pediatric tumor of the kidney that arises via failure of the fetal developmental program. The absence of identifiable mutations in the majority of WTs suggests the frequent involvement of epigenetic aberrations in WT. We there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012c60532b00d73f79f85e1a94f89b74
https://www.pure.ed.ac.uk/ws/files/8144707/Frequent_long_range_epigenetic_silencing_of_protocadherin_gene_clusters_on_chromosome_5q31_in_Wilms_tumor.pdf