Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Laxman Ghimire"'
Autor:
Fengxia Ma, Laxman Ghimire, Qian Ren, Yuping Fan, Tong Chen, Arumugam Balasubramanian, Alan Hsu, Fei Liu, Hongbo Yu, Xuemei Xie, Rong Xu, Hongbo R. Luo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Both lytic and apoptotic cell death remove senescent and damaged cells in living organisms. However, they elicit contrasting pro- and anti-inflammatory responses, respectively. The precise cellular mechanism that governs the choice between t
Externí odkaz:
https://doaj.org/article/6968380613d44fba86d6fdc85ef34f14
Autor:
Laxman Ghimire, Sagar Paudel, John Le, Liliang Jin, Shanshan Cai, Dinesh Bhattarai, Samithamby Jeyaseelan
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSepsis remains a major cause of death in Intensive Care Units. Sepsis is a life-threatening multi-organ dysfunction caused by a dysregulated systemic inflammatory response. Pattern recognition receptors, such as TLRs and NLRs contribute t
Externí odkaz:
https://doaj.org/article/f0e2f60eaf86464bbcf7aca8b6046c69
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
During acute infectious and inflammatory conditions, a large number of neutrophils are in high demand as they are consumed in peripheral organs. The hematopoietic system rapidly responds to the demand by turning from steady state to emergency granulo
Externí odkaz:
https://doaj.org/article/68c3817c7fdd4f98adc0a4ac51a7ec3e
Publikováno v:
PLoS Pathogens, Vol 14, Iss 9, p e1007308 (2018)
Gram-positive bacteria, including Staphylococcus aureus are endemic in the U.S., which cause life-threatening necrotizing pneumonia. Neutrophils are known to be critical for clearance of S. aureus infection from the lungs and extrapulmonary organs. T
Externí odkaz:
https://doaj.org/article/a49d943a4376460d93310d449c76196c
Autor:
Arumugam Balasubramanian, Laxman Ghimire, Alan Y. Hsu, Hiroto Kambara, Xing Liu, Tomoya Hasegawa, Rong Xu, Muhammad Tahir, Hongbo Yu, Judy Lieberman, Hongbo R. Luo
Publikováno v:
bioRxiv
Gasdermin D (GSDMD)-mediated macrophage pyroptosis plays a critical role in inflammation and host defense. Plasma membrane perforation elicited by caspase-cleaved GSDMD N-terminal domain (GSDMD-NT) triggers membrane rupture and subsequent pyroptotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::addd8e19e4601ee0ddd9e7477a568a18
https://europepmc.org/articles/PMC9980122/
https://europepmc.org/articles/PMC9980122/
Autor:
Fei Liu, Laxman Ghimire, Arumugam Balasubramanian, Alan Y. Hsu, Zhaoran Zhang, Hongbo Yu, Fengxia Ma, Hongbo R. Luo
Publikováno v:
Blood.
Autor:
Sivakumar Periasamy, Shanshan Cai, Sagar Paudel, John T. Le, Laxman Ghimire, Samithamby Jeyaseelan, Liliang Jin, Tirumalai Rangasamy
Publikováno v:
J Immunol
Klebsiella pneumoniae is a common cause of Gram-negative pneumonia. The spread of antibiotic-resistant and hypervirulent strains has made treatment more challenging. This study sought to determine the immunomodulatory, antibacterial, and therapeutic