Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Laxma G. Reddy"'
Autor:
Jody L. Lutterman, Sean M. Mcgurran, Laxma G. Reddy, Kevin S. Gorski, Calin D. Dumitru, Elaine A. Egging, Kenneth E. Lipson, Melissa M. Piri, Gary W. Gullikson, Dave D. Johnson, Felicia R. Cochran, Mark A. Tomai, Mary A. Antonysamy, Joel Proksch
Publikováno v:
Cancer Immunology, Immunotherapy. 58:575-587
Innate immune stimulation with Toll-like receptor (TLR) agonists is a proposed modality for immunotherapy of melanoma. Here, a TLR7/8 agonist, 3M-011, was used effectively as a single systemic agent against disseminated mouse B16-F10 melanoma. The in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bdbe93f142191f83b42d1b7b4b788af
https://doi.org/10.1007/s00262-008-0581-7
https://doi.org/10.1007/s00262-008-0581-7
Defining the Molecular Components of Calcium Transport Regulation in a Reconstituted Membrane System
Publikováno v:
Biochemistry. 42:4585-4592
Using a chemically defined reconstitution system, we performed a systematic study of key factors in the regulation of the Ca-ATPase by phospholamban (PLB). We varied both the lipid/protein and PLB/Ca-ATPase ratios, determined the effects of PLB phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6d116a55199ea947d8304c713ebd89
https://doi.org/10.1021/bi026995a
https://doi.org/10.1021/bi026995a
Publikováno v:
Biophysical Journal. 76:2587-2599
We have developed a method using fluorescence energy transfer (FET) to analyze protein oligomeric structure. Two populations of a protein are labeled with fluorescent donor and acceptor, respectively, then mixed at a defined donor/acceptor ratio. A t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a9e2b85f83dd01cbeba231782f5ca9
https://doi.org/10.1016/s0006-3495(99)77411-4
https://doi.org/10.1016/s0006-3495(99)77411-4
Publikováno v:
Biochemistry. 38:3954-3962
Phospholamban (PLB), a 52-amino acid protein, regulates the Ca-ATPase (calcium pump) in cardiac sarcoplasmic reticulum (SR) through PLB phosphorylation mediated by beta-adrenergic stimulation. The mobility of PLB on SDS-PAGE indicates a homopentamer,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38521fdf0ee5f59a0dc121f46b744c17
https://doi.org/10.1021/bi981795d
https://doi.org/10.1021/bi981795d
Publikováno v:
Annals of the New York Academy of Sciences. 853:103-115
Significant advances have recently been made in understanding the regulation of Ca(2+)-ATPase by phospholamban and in modeling their structures. However, these insights would be furthered by determining the 3-D structure of both proteins within the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd6d27f2b26999945ed31190b1d334e
https://doi.org/10.1111/j.1749-6632.1998.tb08260.x
https://doi.org/10.1111/j.1749-6632.1998.tb08260.x
Publikováno v:
Biochemistry. 34:4448-4456
We have studied the secondary structure of native phospholamban (PLB), a 52-residue integral membrane protein that regulates calcium uptake into the cardiac sarcoplasmic reticulum, as well as its 27-residue carboxy-terminal transmembrane segment (PLB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893b60f6173487a6f3091f4bbcf63cb9
https://doi.org/10.1021/bi00013a038
https://doi.org/10.1021/bi00013a038
Autor:
Jeffrey J. O'Brian, Suren A. Tatulian, Larry R. Jones, Laxma G. Reddy, David L. Stokes, Steven E. Cala
Publikováno v:
Journal of Biological Chemistry. 270:9390-9397
Phospholamban (PLB) is a small, transmembrane protein that resides in the cardiac sarcoplasmic reticulum (SR) and regulates the activity of Ca(2+)-ATPase in response to beta-adrenergic stimulation. We have used the baculovirus expression system in Sf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d906943ad3db75d95b583a158f6fb2e7
https://doi.org/10.1074/jbc.270.16.9390
https://doi.org/10.1074/jbc.270.16.9390
Publikováno v:
The Journal of biological chemistry. 281(49)
Toll-like receptors (TLRs) TLR1, TLR2, TLR4, and TLR6 are evolutionarily conserved, highly homologous, and localized to plasma membranes of host cells and recognize pathogen-associated molecular patterns (PAMPs) derived from bacterial membranes. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567912be88628465b7198a747c6f0502
https://pubmed.ncbi.nlm.nih.gov/17040905
https://pubmed.ncbi.nlm.nih.gov/17040905
Autor:
Gregory W. Hunter, Laxma G. Reddy, David D. Thomas, Yvonne M. Angell, Christine B. Karim, George Barany
Publikováno v:
Peptides for the New Millennium ISBN: 0792364457
Calcium transport into the sarcoplasmic reticulum of cardiac muscle is catalyzed by the Ca pump and regulated by phospholamban (PLB), a 52-amino acid integral membrane peptide that inhibits the pump [1]. PLB is predominantly a homopentamer on electro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3213c240034a0e3971821dcb4056ca9
https://doi.org/10.1007/0-306-46881-6_153
https://doi.org/10.1007/0-306-46881-6_153
Autor:
George Barany, M. Germana Paterlini, Laxma G. Reddy, David D. Thomas, Gregory W. Hunter, Christine B. Karim
Publikováno v:
The Journal of biological chemistry. 276(42)
To study the structural and functional roles of the cysteine residues at positions 36, 41, and 46 in the transmembrane domain of phospholamban (PLB), we have used Fmoc (N-(9-fluorenyl)methoxycarbonyl) solid-phase peptide synthesis to prepare alpha-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efd4c37142faa07009be1c6aa7b113a
https://pubmed.ncbi.nlm.nih.gov/11477077
https://pubmed.ncbi.nlm.nih.gov/11477077