Výsledky vyhledávání - "Laximan Velip"

Involvement of Microbiome Gut–Brain Axis in Neuroprotective Effect of Quercetin in Mouse Model of Repeated Mild Traumatic Brain Injury

Autor: Ramya Balasubramanian, Mohd Rabi Bazaz, Tulasi Pasam, Naserunnisa Sharief, Laximan Velip, Gananadhamu Samanthula, Manoj P. Dandekar

Publikováno v: NeuroMolecular Medicine.

Repeated mild traumatic brain injury (rmTBI) poses adversity in the form of neurological deficits. The ignition of long-term neurological aberrations post-TBI is appended with the microbiota gut-brain axis perturbation. Herein, we examined whether qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe99bde4ceab8d9f9c05ecb7c97e0df
https://doi.org/10.1007/s12017-022-08732-z

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LC-HRMS and NMR studies for characterization of forced degradation impurities of ponatinib, a tyrosine kinase inhibitor, insights into in-silico degradation and toxicity profiles

Autor: Vijaya Madhyanapu Golla, Bhoopendra Singh Kushwah, Vivek Dhiman, Laximan Velip, Gananadhamu Samanthula

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 227:115280

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86cd65865902954b763039a3f1c48d3d
https://doi.org/10.1016/j.jpba.2023.115280

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Comprehensive degradation profiling and influence of different oxidizing reagents on tinoridine hydrochloride: Structural characterization of its degradation products using HPLC and HRMS

Autor: Kanchan Patil, Vivek Dhiman, Laximan Velip, S. Gananadhamu, M.V.N. Kumar Talluri

Publikováno v: Rapid Communications in Mass Spectrometry. 36

RATIONALE Stress testing on tinoridine hydrochloride was carried out using a multidimensional approach. This included the hydrolytic (acidic, alkaline and neutral condition), different oxidative reagents, thermal, photolytic conditions, HPLC method d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7942315cb03ad73209e6c5c0036ab473
https://doi.org/10.1002/rcm.9210

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Author response for 'Comprehensive degradation profiling and influence of different oxidising reagents on tinoridine hydrochloride: Structural characterization of its degradation products using HPLC and HRMS'

Autor: null Vivek Dhiman, null Kanchan Patil, null Laximan Velip, null M. V. N. Kumar Talluri, null S. Gananadhamu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27ef7990264b3e9ee6defd5224fb10c9
https://doi.org/10.1002/rcm.9210/v2/response1

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Identification and characterization of urapidil stress degradation products by LC-Q-TOF-MS and NMR: Toxicity prediction of degradation products

Autor: Laximan, Velip, Vivek, Dhiman, Bhoopendra Singh, Kushwah, Vijaya Madhyanapu, Golla, S, Gananadhamu

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 211:114612

Urapidil, an antihypertensive drug is subjected to various stress conditions (acidic, basic, neutral, oxidative and photolytic) as per ICH guidelines. A stability indicating HPLC method was developed using InertSustain C8 (250 × 4.6 mm; 5 µm) colum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2648d934406228306ddae2c6c53cc6c
https://doi.org/10.1016/j.jpba.2022.114612

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Stress degradation study on entrectinib and characterization of its degradation products using HRMS and NMR

Autor: Vivek Dhiman, Ankit Balhara, Saranjit Singh, Laximan Velip, Gananadhamu Samanthula, Vijaya Madhyanapu Golla, Bhoopendra Singh Kushwah

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 208:114459

Entrectinib is a potent inhibitor of receptor tyrosine kinases and anaplastic lymphoma kinase. It is designated as an orphan drug. There exists no report of comprehensive degradation profiling of the drug in the literature. Therefore, the present stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f453daab4f30599ef4c1d535f0a54f2
https://doi.org/10.1016/j.jpba.2021.114459

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