Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Laxiang Wan"'
Autor:
Deliang Cao, Duan-Fang Liao, William F. Stenson, Mei Chris Huang, Jianghua Liu, Xuyu Zu, Laxiang Wan, Yingchun He, Yu Cao, Yiwen Bu, Chenfei Huang, John Gao, Wancai Yang, Xiaoning Li, Hongyan Ling, Ruilan Yan, Jun Ma, Yi Shen
Purpose: Ulcerative colitis and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Aldo-keto reductase 1B10 (AKR1B10) is specifically expressed in the colonic epithelium, but downregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7aa35704aa330e5e813dbe5e4ddae1
https://doi.org/10.1158/1078-0432.c.6523917
https://doi.org/10.1158/1078-0432.c.6523917
Autor:
Deliang Cao, Duan-Fang Liao, William F. Stenson, Mei Chris Huang, Jianghua Liu, Xuyu Zu, Laxiang Wan, Yingchun He, Yu Cao, Yiwen Bu, Chenfei Huang, John Gao, Wancai Yang, Xiaoning Li, Hongyan Ling, Ruilan Yan, Jun Ma, Yi Shen
Supplemental Figures S1-6, Tables S1-7. Figure S1. Targeted disruption of AKR1B8 gene. Figure S2. AKR1B and AKR1C subfamily expression. Figure S3. Deficiency of proliferation and self-renewal of colonic crypt cells in AKR1B8 -/- mice. Figure S4. DSS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac58dd7208294b177c0224ed74e2203
https://doi.org/10.1158/1078-0432.22458351.v1
https://doi.org/10.1158/1078-0432.22458351.v1
Autor:
Tong Wang, Lawrence G. Palmer, Laxiang Wan, Shuhua Xu, Jing Li, Ryo Hatano, Alan M. Weinstein, Lei Yang
Publikováno v:
American Journal of Physiology-Renal Physiology. 313:F505-F513
We studied gender differences in Na+-Cl− cotransporter (NCC) activity and expression in wild-type (WT) and AT1a receptor knockout (KO) mice. In renal clearance experiments, urine volume (UV), glomerular filtration rate, absolute Na+ (ENa) and K+ (E
Autor:
Qingshang Yan, Wen-Hui Wang, Junhua Guo, Haiyan Hu, Ke Dong, Steven C. Hebert, Ming Lu, Laxiang Wan, Emile L. Boulpaep, Gerhard Giebisch, Tong Wang
Publikováno v:
Journal of Biological Chemistry. 291:5259-5269
Romk knock-out mice show a similar phenotype to Bartter syndrome of salt wasting and dehydration due to reduced Na-K-2Cl-cotransporter activity. At least three ROMK isoforms have been identified in the kidney; however, unique functions of any of the
Autor:
Jing, Li, Ryo, Hatano, Shuhua, Xu, Laxiang, Wan, Lei, Yang, Alan M, Weinstein, Lawrence, Palmer, Tong, Wang
Publikováno v:
American journal of physiology. Renal physiology. 313(2)
We studied gender differences in Na
Publikováno v:
American Journal of Physiology-Renal Physiology. 303:F1507-F1516
Underlying glomerulotubular balance (GTB) is the impact of axial flow to regulate Na+and HCO3−transport by modulating Na+-H+exchanger 3 (NHE3) and H-ATPase activity. It is not known whether the cascade of events following a change in flow relies on
Autor:
Laxiang Wan, Bradford Kim, H. Michael Gach, Stuart D. Flynn, Amy Ziemba, James L. McCabe, Deliang Cao, Giuseppe Pizzorno, Ruilan Yan
Publikováno v:
Molecular Cancer Therapeutics. 10:2330-2339
Abrogation of uridine phosphorylase (UPase) leads to abnormalities in pyrimidine metabolism and host protection against 5-fluorouracil (5-FU) toxicity. We elucidated the effects on the metabolism and antitumor efficacy of 5-FU and capecitabine (N4-pe
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 29:488-503
Uridine phosphorylase (UPase) has been shown to be induced in various human and murine tumors and could potentially serve as a specific target for the modulation of tumor-selectivity of fluoropyrimidines. However, the signaling mechanisms underlying
Autor:
Deliang Cao, John Gao, Xiaoning Li, Duan-Fang Liao, Yi Shen, Hongyan Ling, Wancai Yang, Mei Chris Huang, Ruilan Yan, Jun Ma, Yiwen Bu, Yingchun He, William F. Stenson, Xuyu Zu, Chenfei Huang, Laxiang Wan, Jianghua Liu, Yu Cao
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 21(6)
Purpose: Ulcerative colitis and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Aldo-keto reductase 1B10 (AKR1B10) is specifically expressed in the colonic epithelium, but downregulat
In response to volume expansion, locally generated dopamine decreases proximal tubule reabsorption by reducing both Na/H-exchanger 3 (NHE3) and Na-K-ATPase activity. We have previously demonstrated that mouse proximal tubules in vitro respond to chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9def6f54090581c6f7ac700fa39468
https://europepmc.org/articles/PMC3433864/
https://europepmc.org/articles/PMC3433864/