Zobrazeno 1 - 10 of 931 pro vyhledávání: '"Lawson, AD"'
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Improved tumor targeting with chemically cross-linked recombinant antibody fragments
Autor: King, DJ, Turner, A, Farnsworth, AP, Adair, JR, Owens, RJ, Pedley, RB, Baldock, D, Proudfoot, KA, Lawson, AD, Beeley, NR
The construction and use of recombinant chimeric and later fully humanized (CDR-grafted) antibodies to tumor-associated antigens has reduced the immune response generated to these antibodies in clinical studies. However, their long circulating half-l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::62ab984ff9fe8b16827b8a9ff52b72b6
https://ora.ox.ac.uk/objects/uuid:499db092-6b7a-41e3-8b23-142e5c0db9ed
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2
Akademický článek
The allosteric modulation of complement C5 by knob domain peptides.
Autor: Macpherson A; UCB, Slough, United Kingdom.; Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom., Laabei M; Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom., Ahdash Z; UCB, Slough, United Kingdom., Graewert MA; European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany., Birtley JR; UCB, Slough, United Kingdom., Schulze ME; UCB, Slough, United Kingdom., Crennell S; Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom., Robinson SA; Department of Statistics, University of Oxford, Oxford, United Kingdom., Holmes B; UCB, Slough, United Kingdom., Oleinikovas V; UCB, Slough, United Kingdom., Nilsson PH; UCB, Slough, United Kingdom.; Department of Chemistry and Biomedicine, Linnaeus University, Kalmar, Sweden.; Department of Immunology, Oslo University Hospital, University of Oslo, Oslo, Norway., Snowden J; UCB, Slough, United Kingdom., Ellis V; UCB, Slough, United Kingdom., Mollnes TE; Department of Immunology, Oslo University Hospital, University of Oslo, Oslo, Norway.; Research Laboratory, Bodø Hospital, K.G. Jebsen TREC, University of Tromsø, Tromsø, Norway.; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway., Deane CM; Department of Statistics, University of Oxford, Oxford, United Kingdom., Svergun D; European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany., Lawson AD; UCB, Slough, United Kingdom., van den Elsen JM; Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.; Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom.
Publikováno v: ELife [Elife] 2021 Feb 11; Vol. 10. Date of Electronic Publication: 2021 Feb 11.
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3
Akademický článek
Revolutionizing cancer treatment: an in-depth exploration of CAR-T cell therapies.
Autor: Kandav G; Chandigarh College of Pharmacy, Chandigarh Group of Colleges, Landran, Sahibzada Ajit Singh Nagar, Punjab, 140307, India. gurpreetk11.1990@gmail.com., Chandel A; Chandigarh College of Pharmacy, Chandigarh Group of Colleges, Landran, Sahibzada Ajit Singh Nagar, Punjab, 140307, India.
Publikováno v: Medical oncology (Northwood, London, England) [Med Oncol] 2024 Oct 14; Vol. 41 (11), pp. 275. Date of Electronic Publication: 2024 Oct 14.
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4
Akademický článek
Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
Autor: Stöppler D; Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany., Macpherson A; UCB Celltech, Slough, United Kingdom., Smith-Penzel S; Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland., Basse N; Sanofi, Strasbourg, France., Lecomte F; UCB Celltech, Slough, United Kingdom., Deboves H; Evotec, Milton, United Kingdom., Taylor RD; UCB Celltech, Slough, United Kingdom., Norman T; UCB Celltech, Slough, United Kingdom., Porter J; Midatech Pharma Plc, Milton, United Kingdom., Waters LC; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom., Westwood M; UCB Celltech, Slough, United Kingdom., Cossins B; UCB Celltech, Slough, United Kingdom., Cain K; Vertex, Milton, United Kingdom., White J; UCB Celltech, Slough, United Kingdom., Griffin R; UCB Celltech, Slough, United Kingdom., Prosser C; UCB Celltech, Slough, United Kingdom., Kelm S; UCB Celltech, Slough, United Kingdom., Sullivan AH; Beryllium Discovery, Bedford, Massachusetts, United States of America., Fox D 3rd; Beryllium Discovery, Bedford, Massachusetts, United States of America., Carr MD; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom., Henry A; UCB Celltech, Slough, United Kingdom., Taylor R; UCB Celltech, Slough, United Kingdom., Meier BH; Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland., Oschkinat H; Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany., Lawson AD; UCB Celltech, Slough, United Kingdom.
Publikováno v: PLoS biology [PLoS Biol] 2018 May 21; Vol. 16 (5), pp. e2006192. Date of Electronic Publication: 2018 May 21 (Print Publication: 2018).
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5
Akademický článek
Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors.
Autor: Chen, Tong1 (AUTHOR), Wang, Mingzhao1 (AUTHOR), Chen, Yanchao1 (AUTHOR), Liu, Yutao1 (AUTHOR) liuyutao@cicams.ac.cn
Publikováno v: Cancer Cell International. 4/16/2024, Vol. 24 Issue 1, p1-24. 24p.
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6
Akademický článek
The Art of Bioimmunogenomics (BIGs) 5.0 in CAR-T Cell Therapy for Lymphoma Management.
Autor: Anurogo, Dito1,2 (AUTHOR), Luthfiana, Dewi3 (AUTHOR), Anripa, Nuralfin4,5 (AUTHOR), Fauziah, Apriliani Ismi6 (AUTHOR), Soleha, Maratu7,8 (AUTHOR), Rahmah, Laila9,10 (AUTHOR), Ratnawati, Hana11 (AUTHOR), Wargasetia, Teresa Liliana11 (AUTHOR), Pratiwi, Sari Eka12 (AUTHOR), Siregar, Riswal Nafi7 (AUTHOR), Sholichah, Ratis Nour13 (AUTHOR), Maulana, Muhammad Sobri14 (AUTHOR), Ikrar, Taruna15,16,17,18,19 (AUTHOR) dr.ikrar.phd@gmail.com, Chang, Yu Hsiang1,20 (AUTHOR), Qiu, Jiantai Timothy1,21,22 (AUTHOR) dr.ikrar.phd@gmail.com
Publikováno v: Advanced Pharmaceutical Bulletin. 2024, Vol. 14 Issue 2, p314-330. 17p.
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8
Akademický článek
Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery.
Autor: Taylor RD; UCB , 216 Bath Road, Slough, SL1 3WE, U.K., MacCoss M; Bohicket Pharma Consulting LLC , 2556 Seabrook Island Road, Seabrook Island, South Carolina 29455, United States., Lawson AD; UCB , 216 Bath Road, Slough, SL1 3WE, U.K.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Mar 09; Vol. 60 (5), pp. 1638-1647. Date of Electronic Publication: 2016 Dec 23.
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9
Akademický článek
Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
Autor: Adams R; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Burnley RJ; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Valenzano CR; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Qureshi O; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Doyle C; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Lumb S; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Del Carmen Lopez M; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Griffin R; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., McMillan D; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Taylor RD; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Meier C; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Mori P; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Griffin LM; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Wernery U; Central Veterinary Research Laboratory, P.O.Box 597, Dubai, United Arab Emirates., Kinne J; Central Veterinary Research Laboratory, P.O.Box 597, Dubai, United Arab Emirates., Rapecki S; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Baker TS; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Lawson AD; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Wright M; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK., Ettorre A; New Medicines, UCB-Celltech, 208 Bath Road, SL1 3WE, Slough UK.
Publikováno v: Scientific reports [Sci Rep] 2017 Jan 30; Vol. 7, pp. 37716. Date of Electronic Publication: 2017 Jan 30.
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10
Akademický článek
Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping.
Autor: Liu X; UCB Celltech, 216 Bath Road, Slough, United Kingdom., Taylor RD; UCB Celltech, 216 Bath Road, Slough, United Kingdom., Griffin L; UCB Celltech, 216 Bath Road, Slough, United Kingdom., Coker SF; UCB Celltech, 216 Bath Road, Slough, United Kingdom., Adams R; UCB Celltech, 216 Bath Road, Slough, United Kingdom., Ceska T; UCB Celltech, 216 Bath Road, Slough, United Kingdom., Shi J; UCB Pharma, Chemin du Foriest 1, B-1420 Braine-l'Alleud, Belgium., Lawson AD; UCB Celltech, 216 Bath Road, Slough, United Kingdom., Baker T; UCB Celltech, 216 Bath Road, Slough, United Kingdom.
Publikováno v: Scientific reports [Sci Rep] 2017 Jan 27; Vol. 7, pp. 41306. Date of Electronic Publication: 2017 Jan 27.
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