Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Lawryn H Kasper"'
Autor:
Fei Zheng, Lawryn H Kasper, David C Bedford, Stephanie Lerach, Brett J W Teubner, Paul K Brindle
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146366 (2016)
Autism spectrum disorders (ASDs) are a group of neurodevelopmental afflictions characterized by repetitive behaviors, deficits in social interaction, and impaired communication skills. For most ASD patients, the underlying causes are unknown. Genetic
Externí odkaz:
https://doaj.org/article/fe14a33335c3421ebb6736fc080bf41f
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102076 (2014)
MED23, a subunit of the Mediator coactivator complex, is important for the expression of a subset of MAPK/ERK pathway-responsive genes, the constituents of which vary between cell types for reasons that are not completely clear. MAPK/ERK pathway-depe
Externí odkaz:
https://doaj.org/article/7087fad1fa4f4189b4243ad7a21d7f9b
Autor:
Lawryn H Kasper, Tomofusa Fukuyama, Stephanie Lerach, Yunchao Chang, Wu Xu, Song Wu, Kelli L Boyd, Paul K Brindle
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82684 (2013)
Adult blood cell production or definitive hematopoiesis requires the transcription factor c-Myb. The closely related KAT3 histone acetyltransferases CBP (CREBBP) and p300 (EP300) bind c-Myb through their KIX domains and mice homozygous for a p300 KIX
Externí odkaz:
https://doaj.org/article/2c85f4f85a3f48deb1b5925a3920a8f0
Autor:
Noa Furth, Danielle Algranati, Bareket Dassa, Olga Beresh, Vadim Fedyuk, Natasha Morris, Lawryn H. Kasper, Dan Jones, Michelle Monje, Suzanne J. Baker, Efrat Shema
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110836- (2022)
Summary: Cancer-associated mutations in genes encoding histones dramatically reshape chromatin and support tumorigenesis. Lysine to methionine substitution of residue 27 on histone H3 (K27M) is a driver mutation in high-grade pediatric gliomas, known
Externí odkaz:
https://doaj.org/article/117f2901cfb8476fbc341b4a3a4df1bc
Autor:
Suzanne J. Baker, Lawryn H. Kasper
Publikováno v:
Neuropathology and Applied Neurobiology. 46:73-85
Paediatric diffuse high-grade gliomas (pHGG) are rare, but deadly tumours. The discovery of recurrent mutations in the tail of histone H3, changing lysine 27 to methionine, or glycine 34 to arginine or valine, has illuminated a critical role for epig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21c1028da308f7998f73d70824fccb4e
https://doi.org/10.1111/nan.12591
https://doi.org/10.1111/nan.12591
Autor:
Kaitlin Budd, Chang-Hyuk Kwon, Lawryn H. Kasper, Christopher Roberts, Jordan Roach, Jennifer Ocasio-Adorno, Jon D. Larson, Suzanne J. Baker
Publikováno v:
Cancer Research. 82:IA007-IA007
Pediatric diffuse high-grade gliomas (HGGs) are a heterogeneous spectrum of disease with abysmal survival rates. Approximately half of diffuse high-grade gliomas in children arise in midline structures predominantly the brainstem, but also thalamus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c7a423fba47d282d7fb84f349d3f734
https://doi.org/10.1158/1538-7445.cancepi22-ia007
https://doi.org/10.1158/1538-7445.cancepi22-ia007
Autor:
Amar Gajjar, Jinghui Zhang, Yingzhe Wang, Xiaoyan Zhu, William Caufield, Chen He, Xiaoyu Li, Burgess B. Freeman, Zoran Rankovic, Gang Wu, Michelle Monje, Nathaniel R. Twarog, Duane G. Currier, Taosheng Chen, Kimberly S Mercer, Barbara Jonchere, Jason Chiang, Ke Xu, Lawryn H. Kasper, Jia Xie, Laura D. Hover, Ibrahim Qaddoumi, Christopher L. Tinkle, Cynthia Wetmore, Wenwei Lin, Anang A. Shelat, Paul Klimo, Giles W. Robinson, Santhosh A. Upadhyaya, Suzanne J. Baker, Brent A. Orr, Alberto Broniscer, Frederick A. Boop, Paige S. Dunphy, Martine F. Roussel, Paul A. Northcott, Brian Gudenas, Chang-Hyuk Kwon, James T. Dalton, Junyuan Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Pediatric high-grade glioma (pHGG) is a major contributor to cancer-related death in children. In vitro and in vivo disease models reflecting the intimate connection between developmental context and pathogenesis of pHGG are essential to advance unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b378e78d205642842686c121971441
http://europepmc.org/articles/PMC8253809
http://europepmc.org/articles/PMC8253809
Autor:
Brent L. Russell, Celeste Rosencrance, Xiaoyan Zhu, Rachel M. Noyes, Yiping Fan, Donald Yergeau, David Finkelstein, Hongjian Jin, Suzanne J. Baker, Ying Shao, Junyuan Zhang, Jinghui Zhang, Andre B. Silveira, Michael Rusch, Timothy I. Shaw, David W. Ellison, Stanley Pounds, Cynthia Wetmore, Gang Wu, Jon D. Larson, Alberto Broniscer, Liang Ding, Beisi Xu, Lawryn H. Kasper, Kristy Boggs, John Easton
Publikováno v:
Acta Neuropathologica. 137:637-655
Histone H3 K27M mutation is the defining molecular feature of the devastating pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). The prevalence of histone H3 K27M mutations indicates a critical role in DIPGs, but the contribution of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9336427f65ba87c4aecd1da824d81f7e
https://doi.org/10.1007/s00401-019-01975-4
https://doi.org/10.1007/s00401-019-01975-4
Autor:
Chen He, Brian Gudenas, James Dalton, Jason Chiang, Zoran Rankovic, Chang-Hyuk Kwon, Nathaniel R. Twarog, Wenwei Lin, Amar Gajjar, Michelle Monje, Ke Xu, Lawryn H. Kasper, Laura D. Hover, Brent A. Orr, Taosheng Chen, Burgess B. Freeman, Gang Wu, Kimberly S Mercer, Santhosh A. Upadhyaya, Paul Klimo, Yingzhe Wang, Giles W. Robinson, William Caufield, Paige S. Dunphy, Martine F. Roussel, Suzanne J. Baker, Ibrahim Qaddoumi, Cynthia Wetmore, Xiaoyu Li, Jinghui Zhang, Anang A. Shelat, Duane G. Currier, Barbara Jonchere, Christopher L. Tinkle, Paul A. Northcott, Alberto Broniscer, Frederick A. Boop, Junyuan Zhang, Xiaoyan Zhu
Pediatric high-grade glioma (pHGG) is a major contributor to cancer-related death in children.In vitroandin vivodisease models reflecting the intimate connection between developmental context and pathogenesis of pHGG are essential to advance understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50126b367618675b8183d0d1f1bd54c
https://doi.org/10.1101/2020.12.06.407973
https://doi.org/10.1101/2020.12.06.407973
Autor:
Yiping Fan, Gang Wu, Jon D. Larson, Jinghui Zhang, Hongjian Jin, Lawryn H. Kasper, Suzanne J. Baker
Publikováno v:
Bioinformatics
Motivation The traditional reads per million normalization method is inappropriate for the evaluation of ChIP-seq data when treatments or mutations have global effects. Changes in global levels of histone modifications can be detected with exogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c562d86ac3b269ba8a824953f80a21eb
https://doi.org/10.1093/bioinformatics/btz720
https://doi.org/10.1093/bioinformatics/btz720