Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Lawrence Wolfe"'
Autor:
Caroline Richardson, Zining Wu, Henriëtte M. G. Willems, William E. Wixted, Alison Jo-Anne Woolford, Charlotte Mary Griffiths-Jones, Yolanda Sanchez, David Norton, Jeffrey K. Kerns, T.G. Davies, William G. Bonnette, Sharna J. Rich, James F. Callahan, Hong Nie, Lawrence Wolfe, Maria Grazia Carr, Marcel L. Verdonk, William L. Rumsey, Tom D. Heightman
Publikováno v:
Journal of Medicinal Chemistry. 64:15949-15972
The NRF2-mediated cytoprotective response is central to cellular homoeostasis, and there is increasing interest in developing small-molecule activators of this pathway as therapeutics for diseases involving chronic oxidative stress. The protein KEAP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba196f8cf42319174247f8aba6d5c760
https://doi.org/10.1021/acs.jmedchem.1c01351
https://doi.org/10.1021/acs.jmedchem.1c01351
Autor:
Shuping Dong, Yolanda Sanchez, Tindy Li, Claudia E. Murar, Anthony J. Wilson, Brent W. Mccleland, Hongwei Qi, Patricia L. Podolin, Marc Galop, Christopher J. Moody, Hongxing Yan, John Yonchuk, Roderick S. Davis, Alan P. Graves, Catherine Booth-Genthe, Joseph P. Foley, Jen-Pyng Kou, Jeffrey K. Kerns, Brian Bolognese, James F. Callahan, Mary Mentzer, Lawrence Wolfe, Jeffrey C. Boehm, Robin Carr
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:579-588
The antioxidant natural product sulforaphane (SFN) is an oil with poor aqueous and thermal stability. Recent work with SFN has sought to optimize methods of formulation for oral and topical administration. Herein we report the design of new analogs o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b415f7b6666ea7f677038e87013d3b1
https://doi.org/10.1016/j.bmc.2018.12.026
https://doi.org/10.1016/j.bmc.2018.12.026
Autor:
Lawrence Wolfe-Xavier
The world was quietly going about its'normal business'when late in 2019 the entire global world of 195 countries, even China, was turned completely on its head by a fake'virus'and a fake'pandemic'. However, the world was not to know at the time, and
Autor:
Jak Grimes, Zining Wu, Sapna Desai, Andrew J. Brown, Angela Bridges, Neil Charter, Andrew M. Mason, Albert Isidro-Llobet, Deidre Dalmas Wilk, Lakshmi Anantharaman, Andrew R. Green, James Lodge, Rita Moita Santos, Lawrence Wolfe
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
Activation of MrgX2, an orphan G protein‐coupled receptor expressed on mast cells, leads to degranulation and histamine release. Human MrgX2 binds promiscuously to structurally diverse peptides and small molecules that tend to have basic properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1af92083a17c29e9066700e43a62bab
https://doaj.org/article/d52477c4710a45b380964101c0429cd7
https://doaj.org/article/d52477c4710a45b380964101c0429cd7
Autor:
Lawrence Wolfe-Xavier
Today's lifestyles do not provide us with the foundations for true, long-term happiness. The causes of our problems are clearly identified, with achievable solutions proposed for us all. The Covid-19 Disaster globally halted'Normal Life', the root ca
Autor:
Hu Li, Hongwei Qi, Brian Donovan, Ming Jiang, Derek D. Poore, Zining Wu, Michael Fischer, Subhas J. Chakravorty, Lawrence Wolfe, Thomas D. Sweitzer, Glenn A. Hofmann
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(2)
Nrf2, a master regulator of the phase II gene response to stress, is kept at low concentrations in the cell through binding to Keap1, an adaptor protein for the Cul3 ubiquitin ligase complex. To identify Nrf2 activators, two separate time-resolved fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c412b192a8a78edb39df6756b4fcfa
https://pubmed.ncbi.nlm.nih.gov/30383469
https://pubmed.ncbi.nlm.nih.gov/30383469
Autor:
James Louie, Kristine Karkoska, Sujatha Rajan, Abena Appiah-Kubi, Lawrence Wolfe, Banu Aygun, Lorry G. Rubin
Publikováno v:
Pediatric bloodcancer. 65(1)
The intracellular parasites Babesia microti and Babesia duncani can be transmitted by blood transfusion and cause severe life-threatening hemolytic anemia in high-risk patients, including those with sickle cell disease. The rarity of the diagnosis, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8015c1df2d397cca93021dc8dd8ef1a7
https://pubmed.ncbi.nlm.nih.gov/28766838
https://pubmed.ncbi.nlm.nih.gov/28766838
Autor:
Zining Wu, Lawrence Wolfe, Andrew R. Green, Deidre Dalmas Wilk, Neil Charter, Jak Grimes, Rita Moita Santos, Albert Isidro Llobet, Andrew M. Mason, Sapna Desai, Andrew J. Brown
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d65ec38f1b8aee6acc54ec95199b3428
https://doi.org/10.1016/j.vascn.2019.05.084
https://doi.org/10.1016/j.vascn.2019.05.084
Autor:
Susmita, Sarangi, Lucie, Lanikova, Katarina, Kapralova, Suchitra, Acharya, Sabina, Swierczek, Jeffrey M, Lipton, Lawrence, Wolfe, Josef T, Prchal
Publikováno v:
Pediatric bloodcancer. 61(11)
von Hippel-Lindau (VHL) protein is the principal negative regulator of hypoxia sensing mediated by transcription factors. Mutations in exon 3 of the VHL gene lead to Chuvash (VHL(R200W)) and Croatian (VHL(H191D)) polycythemias. Here, we describe an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38d3a8da8244da80910e25c53ca92314
https://pubmed.ncbi.nlm.nih.gov/24729484
https://pubmed.ncbi.nlm.nih.gov/24729484
Autor:
Robert J. Arceci, M.D., Suchitra S. Acharya, Melissa A. Alderfer, Mark Atlas, Rochelle Bagatell, Mary Ann Bonilla, James Bussel, Mitchell S. Cairo, Andrew Chen, Jeffrey Dome, Steven DuBois, Carolyn Fein Levy, Jonathan Fish, Debra L. Friedman, Richard Gorlick, Eric Gratias, Jessica Hochberg, Katherine A. Janeway, Janet L. Kwiatkowski, Philip Lanzkowsky, Jeffrey M. Lipton, Neyssa Marina, Jill S. Menell, Thomas A. Olson, Pinki Prasad, Julie R. Park, Josef T. Prchal, Arlene Redner, Thomas Renaud, Susan Rheingold, Lorry Glen Rubin, Indira Sahdev, Jessica Scerbo, David T. Teachey, M. Issai Vanan, Leonard H. Wexler, Lori S. Wiener, Lawrence Wolfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9df50a1c152baa2f8f19c2398628f03d
https://doi.org/10.1016/b978-0-12-375154-6.00037-9
https://doi.org/10.1016/b978-0-12-375154-6.00037-9