Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lawrence W. L. Woo"'
Autor:
Lawrence W. L. Woo, D. C. Parish, Christopher R. Ireson, Surinder K. Chander, Michael J. Reed, Atul Purohit, Barry V. L. Potter
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 84:337-342
Steroid sulphatase inhibitors which decrease or prevent the biosynthesis of oestrogens, potentially have an important role in the treatment of breast cancer in postmenopausal women. The non-steroidal sulphatase inhibitor 667 COUMATE has been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90595fad6b6356ef6bc0c1e08d05ec7e
https://doi.org/10.1016/s0960-0760(03)00047-5
https://doi.org/10.1016/s0960-0760(03)00047-5
Autor:
K.A. Vernon, Barry V. L. Potter, Michael J. Reed, A.E. Wagenaar Hummelinck, Lawrence W. L. Woo, Atul Purohit, Hatem Hejaz
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 64:269-275
Steroid sulphatases regulate the formation of oestrogenic steroids which can support the growth of endocrine-dependent breast tumours. The development of potent steroid sulphatase inhibitors could therefore have considerable therapeutic potential. Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146a0dc3c518165935900f14441213e9
https://doi.org/10.1016/s0960-0760(97)00196-9
https://doi.org/10.1016/s0960-0760(97)00196-9
Autor:
Sergio Abbate, Giovanna Longhi, Ettore Castiglioni, France Lebon, Paul M. Wood, Lawrence W. L. Woo, Barry V. L. Potter
Publikováno v:
Chirality. 21(9)
The absolute configuration of a newly designed, letrozole-based chiral aromatase inhibitor that could not be defined by crystallographic techniques has been determined by means of vibrational and electronic circular dichroism and by optical rotation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bde57009c555d4760492f776a31f758
https://pubmed.ncbi.nlm.nih.gov/19161217
https://pubmed.ncbi.nlm.nih.gov/19161217
Autor:
A.E. van Strien, Hatem Hejaz, M.J. Reed, Barry V. L. Potter, Lawrence W. L. Woo, Atul Purohit
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 69(1-6)
Inhibition of steroid sulphatase is now an important target for the development of new drugs for the treatment of women with endocrine-dependent breast tumours. The first potent sulphatase inhibitor identified, oestrone-3-O-sulphamate (EMATE) proved,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e58f78db009cde4dee54b1a67339fd5
https://pubmed.ncbi.nlm.nih.gov/10418996
https://pubmed.ncbi.nlm.nih.gov/10418996
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2549
Routes are described for the synthesis of 3-alkyl-3-(prop-2-ynyl)pyrrolidine-2,5-diones 5 and 6, which are not available by the literature method for the corresponding prop-2-enyl analogues, and 3-carboxy-3-(prop-2-ynyl)pyrrolidine-2,5-dione 7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df0fba6a1209c916b5c52ed1bc7e55be
https://doi.org/10.1039/p19930002549
https://doi.org/10.1039/p19930002549