Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lawrence W. Hartley"'
Autor:
Bach Nicholas J, Dennis R. Berry, Robert D. Dillard, Edward David Mihelich, Jean-Pierre Wery, Cynthia D. Sommers, Lea M. Johnson, David W. Snyder, Donald G. Carlson, David K. Clawson, Emma R. McKinney, Amy C. Smith, Richard Walter Schevitz, Susan E. Draheim, Lawrence W. Hartley, Jennifer L. Olkowski, Noel D. Jones, Nickolay Y. Chirgadze
Publikováno v:
Journal of Medicinal Chemistry. 39:5137-5158
As reported in our previous paper, a series of indole-3-acetamides which possessed potency and selectivity as inhibitors of human nonpancreatic secretory phospholipase A2(hnps-PLA2) was developed. The design of these compounds was based on informatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb0858e7cadcd119a6d3f11a160b093
https://doi.org/10.1021/jm960486n
https://doi.org/10.1021/jm960486n
Autor:
Robert D. Dillard, Susan E. Draheim, Bach Nicholas J, Cynthia D. Sommers, Amy C. Smith, Emma R. McKinney, Noel D. Jones, Jennifer L. Olkowski, Edward David Mihelich, Jean-Pierre Wery, David W. Snyder, Lawrence W. Hartley, Donald G. Carlson, Richard Walter Schevitz, Nickolay Y. Chirgadze, Dennis R. Berry, David K. Clawson, Lea M. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 39:5159-5175
Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a4d3e2c3e6fd72e60021a3469bd5da
https://doi.org/10.1021/jm960487f
https://doi.org/10.1021/jm960487f
Autor:
Lawrence W. Hartley, Bach Nicholas J, David W. Snyder, Edward David Mihelich, Robert D. Dillard, Susan E. Draheim, Jean-Pierre Wery, David K. Clawson, C. Sommers, Donald G. Carlson, Richard Walter Schevitz, Jennifer L. Olkowski, Noel D. Jones, Nickolay Y. Chirgadze
Publikováno v:
Nature Structural Biology
A lead compound obtained from a high volume human non-pancreatic secretory phospholipase A2 (hnps-PLA2) screen has been developed into a potent inhibitor using detailed structural knowledge of inhibitor binding to the enzyme active site. Four crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a39496bafe98a1eb877d330d4835647
http://europepmc.org/articles/PMC7097651
http://europepmc.org/articles/PMC7097651
Autor:
Amy C. Smith, Lea M. Johnson, Robert D. Dillard, Lawrence W. Hartley, Donald G. Carlson, Noel D. Jones, Nickolay Y. Chirgadze, Emma R. McKinney, Richard Walter Schevitz, Susan E. Draheim, Jennifer L. Olkowski, Bach Nicholas J, Dennis R. Berry, David W. Snyder, Jean-Pierre Wery, Cynthia D. Sommers, David K. Clawson, Edward David Mihelich
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dccdd1798a2a7acf8d0453faf4a3f38
https://doi.org/10.1002/chin.199716152
https://doi.org/10.1002/chin.199716152
Autor:
Donald G. Carlson, Cynthia D. Sommers, Richard Walter Schevitz, Bach Nicholas J, Susan E. Draheim, Edward David Mihelich, Nickolay Y. Chirgadze, Amy C. Smith, Jennifer L. Olkowski, David K. Clawson, Jean-Pierre Wery, Robert D. Dillard, Noel D. Jones, David W. Snyder, Emma R. McKinney, Dennis R. Berry, Lea M. Johnson, Lawrence W. Hartley
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18953de424a69d0b1c2580eceb94fb59
https://doi.org/10.1002/chin.199716151
https://doi.org/10.1002/chin.199716151
Autor:
Lawrence W. Hartley, Edward C. R. Smith, Richard L. Tielking, Donald G. Carlson, J. Scott Sawyer, Marcia K. Chastain, David W. Snyder, Douglas W. Beight
Publikováno v:
Journal of medicinal chemistry. 48(3)
A vinyl azide cyclization method was used to synthesize three different carbocyclic[g]indole scaffolds as inhibitors of human nonpancreatic secretory phospholipase A2. Each scaffold demonstrated potent enzyme activity in a chromogenic assay system, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebed408d5d7cdb3d012dc7cc4b404e1
https://pubmed.ncbi.nlm.nih.gov/15689175
https://pubmed.ncbi.nlm.nih.gov/15689175
Autor:
Robert D. Dillard, Nicholas J. Bach, Susan E. Draheim, Dennis R. Berry, Donald G. Carlson, Nickolay Y. Chirgadze, David K. Clawson, Lawrence W. Hartley, Lea M. Johnson, Noel D. Jones, Emma R. McKinney, Edward D. Mihelich, Jennifer L. Olkowski, Richard W. Schevitz, Amy C. Smith, David W. Snyder, Cynthia D. Sommers, Jean-Pierre Wery
Publikováno v:
Journal of medicinal chemistry. 39(26)
Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258b47ef40521e42d74456539df7f156
https://pubmed.ncbi.nlm.nih.gov/9005255
https://pubmed.ncbi.nlm.nih.gov/9005255
Autor:
John D. Sharp, Lawrence W. Hartley, James Schrementi, Bach Nicholas J, Min Song, Susan E. Draheim, David W. Snyder, Donald G. Carlson, Jesse L. Bobbitt, Donald L. White, Lawrence Fisher, Niles Fox, Robert D. Dillard, Edward David Mihelich
Publikováno v:
European journal of pharmacology. 308(2)
Transgenic mice were created which overexpress human secretory non-pancreatic phospholipase A2 (sPLA2) pansomatically as a potential disease and drug-testing model. The mice were produced using a DNA construct in which the inducible mouse metallothio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6960cd88c36019cfd5826d9ed593ca
https://pubmed.ncbi.nlm.nih.gov/8840132
https://pubmed.ncbi.nlm.nih.gov/8840132
Autor:
Edward B. Blackmon, Stephen G. Somkuti, Joseph F. Daugherty, Paul A. Vieta, Lawrence W. Hartley
Publikováno v:
American Journal of Obstetrics and Gynecology. 171:567-568
Three premenopausal women had transvaginal evisceration after hysterectomy; the original approach was abdominal in two and vaginal in one. Postoperative cuff infection may contribute to evisceration, and symptoms vary with the length of time after ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1847bd2841a4981f628907e728c2f275
https://doi.org/10.1016/0002-9378(94)90306-9
https://doi.org/10.1016/0002-9378(94)90306-9
Publikováno v:
Journal of Immunological Methods. 58:255-262
Mice were sensitized with sheep red blood cells (SRBC) and challenged 3–7 days later with a mid tail subcutaneous injection of SRBC. Delayed type hypersensitivity (DTH) was assessed by the amount of tail swelling elicited by antigen challenge and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f88eb6e51409e813494d28be07d77d51
https://doi.org/10.1016/0022-1759(83)90280-6
https://doi.org/10.1016/0022-1759(83)90280-6