Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Lawrence W. Dick"'
Autor:
Geoffri Ricci, Kevin Minsker, Austin Kapish, James Osborn, Sha Ha, Joseph Davide, Joseph P. Califano, Darrell Sehlin, Richard R. Rustandi, Lawrence W. Dick, Josef Vlasak, Timothy D. Culp, Andreas Baudy, Edward Bell, Malini Mukherjee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Direct at line monitoring of live virus particles in commercial manufacturing of vaccines is challenging due to their small size. Detection of malformed or damaged virions with reduced potency is rate-limited by release potency assays with l
Externí odkaz:
https://doaj.org/article/6fd2905286724233b97e09383c9378da
Autor:
Pete A. DePhillips, Dai Wang, Colleen E. Price, Matthew C. Troutman, Daniel C. Freed, Lawrence W. Dick, Timothy D. Culp, Guanghua Li, Van M. Hoang, Zhong Liu, Tong-Ming Fu, Sha Ha, John W. Loughney, Richard R. Rustandi, Fengsheng Li
Publikováno v:
Journal of Biological Chemistry. 290:15985-15995
Congenital infection of human cytomegalovirus (HCMV) is one of the leading causes of nongenetic birth defects, and development of a prophylactic vaccine against HCMV is of high priority for public health. The gH/gL/pUL128–131 pentameric complex med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b793d24a341e1e5820b6d42f4602cb09
https://doi.org/10.1074/jbc.m115.652230
https://doi.org/10.1074/jbc.m115.652230
Autor:
Craig T. Przysiecki, Lawrence W. Dick, Lan Zhang, Sha Ha, John T. Mehl, John W. Loughney, Van M. Hoang, Lance Dieter, Richard R. Rustandi, Anna Mach
Publikováno v:
Human Vaccines & Immunotherapeutics. 11:1518-1525
The development of a multivalent outer membrane vesicle (OMV) vaccine where each strain contributes multiple key protein antigens presents numerous analytical challenges. One major difficulty is the ability to accurately and specifically quantitate e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3643cdce91c3dc2d7f3b220da521db6d
https://doi.org/10.1080/21645515.2015.1016678
https://doi.org/10.1080/21645515.2015.1016678
Autor:
Canping, Jiang, Sarah, Scherfner, Lawrence W, Dick, David, Mahon, Difei, Qiu, Kuang-Chuan, Cheng, Abhinav A, Shukla
Publikováno v:
Biotechnology Progress. 27:442-450
The use of yeast- and plant-derived hydrolysates in cell culture production processes has sparked concerns over the potential immunogenicity risk posed by β-glucans and yeast peptides contained in these raw materials. This article utilizes a combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2d9049f1ce69f506ac3049192b708f
https://doi.org/10.1002/btpr.568
https://doi.org/10.1002/btpr.568
Autor:
Difei Qiu, Lawrence W. Dick, John Devincentis, Kuang-Chuan Cheng, Michael Adamo, An-Horng Lee
Publikováno v:
Journal of Chromatography B. 878:1865-1870
In this paper, we discuss an improved high-performance liquid chromatography (HPLC) method for the quantitation of polysorbate 80 (polyoxyethylenesorbitan monooleate), a commonly used stabilizing excipient in therapeutic drug solutions. This method i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e61cb3ebe7249f68788a212faaf0dfd
https://doi.org/10.1016/j.jchromb.2010.04.039
https://doi.org/10.1016/j.jchromb.2010.04.039
Publikováno v:
Journal of Chromatography B. 877:3841-3849
Isomerization plays a key role in protein degradation. This isomerization is often difficult to detect by many protein characterization methods such as SDS-PAGE, SEC, and IEF. This work shows the identification of an isomerized aspartic acid residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8018bb3f288e8282967a1274f478f480
https://doi.org/10.1016/j.jchromb.2009.09.031
https://doi.org/10.1016/j.jchromb.2009.09.031
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 49:181-192
Carbohydrates can change a drug's properties including solubility, affinity towards antigen, pharmacokinetics and pharmacodynamics. Due to this importance, carbohydrate composition is utilized as a parameter to evaluate a drug candidate's quality. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e7f5b0b783d830a489cede01aa8aea
https://doi.org/10.1016/j.jpba.2008.10.008
https://doi.org/10.1016/j.jpba.2008.10.008
Publikováno v:
Biotechnology and Bioengineering. 100:1132-1143
The C-terminal lysine variation is commonly observed in biopharmaceutical monoclonal antibodies. This modification can be important since it is found to be sensitive to the production process. The methods commonly used to probe this charge variation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59fb3fe4fb69a9b4f8492d75b37c2908
https://doi.org/10.1002/bit.21855
https://doi.org/10.1002/bit.21855
Publikováno v:
Analytical Chemistry. 79:273-279
Capture and detection of Immunoglobulin E (IgE) in simple solution and in human serum using an aptamer-modified probe surface for affinity Matrix-Assisted Laser Desorption-Ionization Mass Spectroscopy (affinity MALDI-MS) detection is reported. Detect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bbd154583b0b208a0b6fa9e98f5ac8
https://doi.org/10.1021/ac061256b
https://doi.org/10.1021/ac061256b
Publikováno v:
Analytica Chimica Acta. 519:197-205
G-quartet DNA stationary phases prepared by covalent attachment of the oligonucleotides to capillary surfaces were investigated for separations of albumins of different species in open tubular capillary electrochromatography (OTCEC). Albumins were ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8cc605ae47a1e0a6905d4137563db56
https://doi.org/10.1016/j.aca.2004.04.051
https://doi.org/10.1016/j.aca.2004.04.051