Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Lawrence W. Castellani"'
Autor:
Cynthia Hong, Michele N. Bradley, Xin Rong, Xuping Wang, Alan Wagner, Victor Grijalva, Lawrence W. Castellani, Jon Salazar, Susan Realegeno, Rima Boyadjian, Alan M. Fogelman, Brian J. Van Lenten, Srinivasa T. Reddy, Aldons J. Lusis, Rajendra K. Tangirala, Peter Tontonoz
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1126-1133 (2012)
The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis, but the relative importance of the two LXRs in atheroprotection is incompletely understood. We show here that LXRα, the dominant LXR isotype expressed in live
Externí odkaz:
https://doaj.org/article/ff30e527bbf84aa4bcabb5bb64d96c53
Autor:
Xuebing Feng, Hongyun Li, Alexis A. Rumbin, Xuping Wang, Antonio La Cava, Katherine Brechtelsbauer, Lawrence W. Castellani, Joseph L. Witztum, Aldons J. Lusis, Betty P. Tsao
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 4, Pp 794-805 (2007)
To establish a mouse model of accelerated atherosclerosis in lupus, we generated apolipoprotein E-deficient (apoE−/−) and Faslpr/lpr (Fas−/−) C57BL/6 mice. On a normal chow diet, 5 month old apoE−/−Fas−/− mice had enlarged glomerular
Externí odkaz:
https://doaj.org/article/f0a451837ed84ec1868861f271a8d9f2
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 7, Pp 1366-1377 (2006)
Myeloperoxidase (MPO) is an oxidant-generating enzyme present in macrophages at atherosclerotic lesions and implicated in coronary artery disease (CAD). Although mouse models are important for investigating the role of MPO in atherosclerosis, neither
Externí odkaz:
https://doaj.org/article/8d669045b3ef4657b40d249aadad58c2
Autor:
Sonal S. Sheth, Lawrence W. Castellani, Soumya Chari, Cory Wagg, Christopher K. Thipphavong, Jackie S. Bodnar, Peter Tontonoz, Alan D. Attie, Gary D. Lopaschuk, Aldons J. Lusis
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 1, Pp 123-134 (2005)
Through a positional cloning approach, the thioredoxin-interacting protein gene (Txnip) was recently identified as causal for a form of combined hyperlipidemia in mice (Bodnar, J. S., A. Chatterjee, L. W. Castellani, D. A. Ross, J. Ohmen, J. Cavalcol
Externí odkaz:
https://doaj.org/article/c39a4c3809244d358e1825b60f9f7314
Autor:
Lawrence W. Castellani, Peter Gargalovic, Maria Febbraio, Sarada Charugundla, Ming-Len Jien, Aldons J. Lusis
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 12, Pp 2377-2387 (2004)
We previously demonstrated that transgenic mice overexpressing mouse apolipoprotein A-II (apoA-II) exhibit several traits associated with the insulin resistance (IR) syndrome, including increased atherosclerosis, hypertriglyceridemia, obesity, and IR
Externí odkaz:
https://doaj.org/article/390913d425e547d0800bc73392a84ee9
Autor:
Maria C. de Beer, Lawrence W. Castellani, Lei Cai, Arnold J. Stromberg, Frederick C. de Beer, Deneys R. van der Westhuyzen
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 4, Pp 706-715 (2004)
The class B scavenger receptors SR-BI and CD36 exhibit a broad ligand binding specificity. SR-BI is well characterized as a HDL receptor that mediates selective cholesteryl ester uptake from HDL. CD36, a receptor for oxidized LDL, also binds HDL and
Externí odkaz:
https://doaj.org/article/583f3c19afdf479cb0ec5afef3d4fded
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 4, Pp 563-570 (2001)
Studies with mice have revealed that increased expression of apolipoprotein A-II (apoA-II) results in elevations in high density lipoprotein (HDL), the formation of larger HDL, and the development of early atherosclerosis. We now show that the increa
Externí odkaz:
https://doaj.org/article/27268df6ed784e40916863edc583e473
Autor:
Margarete Mehrabian, Lawrence W. Castellani, Ping-Zi Wen, Jack Wong, Tat Rithaporn, Susan Y. Hama, Gregory P. Hough, David Johnson, John J. Albers, Giuliano A. Mottino, Joy S. Frank, Mohamad Navab, Alan M. Fogelman, Aldons J. Lusis
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 12, Pp 1936-1946 (2000)
Strain CAST/Ei (CAST) mice exhibit unusually low levels of high density lipoproteins (HDL) as compared with most other strains of mice, including C57BL/6J (B6). This appears to be due in part to a functional deficiency of lecithin:cholesterol acyltra
Externí odkaz:
https://doaj.org/article/306b4bc1b7fa4004951a999f20acaf6f
Autor:
Aram Mouzeyan, Junghee Choi, Hooman Allayee, Xuping Wang, Janet Sinsheimer, Jack Phan, Lawrence W. Castellani, Karen Reue, Aldons J. Lusis, Richard C. Davis
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 4, Pp 573-582 (2000)
Dietary cholesterol is known to raise total and low density lipoprotein cholesterol concentrations in humans and experimental animals, but the response among individuals varies greatly. Here we describe a mouse strain, C57BL/6ByJ (B6By), that is resi
Externí odkaz:
https://doaj.org/article/80da8d9fed194748855adc4ad25e741a
Autor:
Jean-Louis Escary, Henry A. Choy, Karen Reue, Xu-Ping Wang, Lawrence W. Castellani, Christopher K. Glass, Aldons J. Lusis, Michael C. Schotz
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 3, Pp 397-404 (1999)
Foam cells formed from receptor-mediated uptake of lipoprotein cholesterol by macrophages in the arterial intima are critical in the initiation, progression, and stability of atherosclerotic lesions. Macrophages accumulate cholesterol when conditions
Externí odkaz:
https://doaj.org/article/49376936a7764534a7790ec4d72423aa