Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Lawrence W Bergman"'
Autor:
Bethany J Jenkins, Thomas M Daly, Joanne M Morrisey, Michael W Mather, Akhil B Vaidya, Lawrence W Bergman
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152197 (2016)
Coenzyme Q (CoQ, ubiquinone) is a central electron carrier in mitochondrial respiration. CoQ is synthesized through multiple steps involving a number of different enzymes. The prevailing view that the CoQ used in respiration exists as a free pool tha
Externí odkaz:
https://doaj.org/article/2d4f7a9080ec4dcc9717e57ae56a768f
Autor:
Akhil B. Vaidya, Lawrence W. Bergman, Michael W. Mather, Joanne M. Morrisey, Thomas M. Daly, Aarti A. Ramanathan
Plasmodium falciparum P-type ATPase (PfATP4) is a Na+ efflux pump crucial for maintaining low [Na+]i in malaria parasites during their intraerythrocytic development cycle. In recent years, multiple studies have shown PfATP4 to be the target of a larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3032a62e7a58752a624f7d5ee71986f0
https://doi.org/10.1101/2019.12.12.874826
https://doi.org/10.1101/2019.12.12.874826
Publikováno v:
Journal of Structural Biology. 178:61-73
The glideosome associated protein GAP50 is an essential protein in apicomplexan parasites such as Plasmodium, Toxoplasma and Cryptosporidium, several species of which are important human pathogens. The 44.6kDa protein is part of a multi-protein compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb3f6baf0fbdae9591c6eee92548e77
https://doi.org/10.1016/j.jsb.2012.02.009
https://doi.org/10.1016/j.jsb.2012.02.009
Autor:
Ijeoma Ejigiri, Photini Sinnis, Thomas M. Daly, Lawrence W. Bergman, Sandhya Kortagere, Joanne M. Morrisey, Akhil B. Vaidya, William J. Welsh
Publikováno v:
Journal of Chemical Information and Modeling. 50:840-849
Malaria is endemic in most developing countries, with nearly 500 million cases estimated to occur each year. The need to design a new generation of antimalarial drugs that can combat the most drug-resistant forms of the malarial parasite is well reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa1e67e7e144c27f401a50e84c6518b
https://doi.org/10.1021/ci100039k
https://doi.org/10.1021/ci100039k
Publikováno v:
Journal of Biological Chemistry. 283:17030-17038
The sexual cycle of Plasmodium is required for transmission of malaria from mosquitoes to mammals, but how parasites induce the expression of genes required for the sexual stages is not known. We disrupted the Plasmodium yoelii gene encoding high mob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838add286dc27b4bd74694a7e3acd46c
https://doi.org/10.1074/jbc.m801637200
https://doi.org/10.1074/jbc.m801637200
Publikováno v:
Eukaryotic Cell. 7:1062-1070
Efficient and specific host cell entry is of exquisite importance for intracellular pathogens. Parasites of the phylum Apicomplexa are highly motile and actively enter host cells. These functions are mediated by type I transmembrane invasins of the T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f0efc46c2aac284e9d0bff52ddb11a
https://doi.org/10.1128/ec.00089-08
https://doi.org/10.1128/ec.00089-08
Autor:
Ronald F. Dumpit, Nelly Camargo, Xinxia Peng, Thomas M. Daly, Yuko Ogata, Lawrence W. Bergman, Alice S. Tarun, Stefan H. I. Kappe, Hilda Silva-Rivera
Publikováno v:
Proceedings of the National Academy of Sciences. 105:305-310
For 50 years since their discovery, the malaria parasite liver stages (LS) have been difficult to analyze, impeding their utilization as a critical target for antiinfection vaccines and drugs. We have undertaken a comprehensive transcriptome analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4f2198cf030d48bdb3b2f15e51a8b0
https://doi.org/10.1073/pnas.0710780104
https://doi.org/10.1073/pnas.0710780104
Publikováno v:
Infection and Immunity. 72:1010-1018
Previously, we described the isolation of thePlasmodium yoeliisequence-related moleculesP. yoeliiMSP-7 (merozoite surface protein 7) andP. yoeliiMSRP-2 (MSP-7-related protein 2) by their ability to interact with the amino-terminal end ofP. yoeliiMSP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58e10ed19755f2c9f952fb9cb42b097
https://doi.org/10.1128/iai.72.2.1010-1018.2004
https://doi.org/10.1128/iai.72.2.1010-1018.2004
Autor:
Sarah Fox, Stefan H. I. Kappe, Victor Nussenzweig, Thomas M. Daly, Lawrence W. Bergman, Isabelle Coppens, Hisashi Fujioka, Kai Matuschewski, Karine Kaiser
Publikováno v:
Journal of Cell Science. 116:39-49
Apicomplexan host cell invasion and gliding motility depend on the parasite's actomyosin system located beneath the plasma membrane of invasive stages. Myosin A (MyoA), a class XIV unconventional myosin, is the motor protein. A model has been propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b8893d27600c3eef897d190f7dbe96
https://doi.org/10.1242/jcs.00194
https://doi.org/10.1242/jcs.00194
Autor:
Peter Siegl, Michael J. Delves, Matthew Berriman, Iñigo Angulo-Barturen, Vicky M. Avery, Boni F. Sebayang, Advait Nagle, Kiaran Kirk, Zhongsheng Zhang, Francisco-Javier Gamo, Matthew Wyvratt, Santiago Ferrer, Natalie J. Spillman, Jeremy N. Burrows, Marcin Stasiak, Joanne M. Morrisey, Thomas D. Otto, María Belén Jiménez-Díaz, Akhil B. Vaidya, Erkang Fan, María Santos Martínez, Jutta Marfurt, Grennady Wirjanata, Susan A. Charman, Thomas M. Daly, Sudipta Das, Arnab K. Chatterjee, Ric N. Price, Andrea Ruecker, Sandhya Kortagere, Lawrence W. Bergman
Publikováno v:
Nature Communications
The quest for new antimalarial drugs, especially those with novel modes of action, is essential in the face of emerging drug-resistant parasites. Here we describe a new chemical class of molecules, pyrazoleamides, with potent activity against human m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe57bc3866498931c4e84248fa3c9a6b
https://doi.org/10.1038/ncomms6521
https://doi.org/10.1038/ncomms6521