Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Lawrence W, Castellani"'
Autor:
Cynthia Hong, Michele N. Bradley, Xin Rong, Xuping Wang, Alan Wagner, Victor Grijalva, Lawrence W. Castellani, Jon Salazar, Susan Realegeno, Rima Boyadjian, Alan M. Fogelman, Brian J. Van Lenten, Srinivasa T. Reddy, Aldons J. Lusis, Rajendra K. Tangirala, Peter Tontonoz
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1126-1133 (2012)
The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis, but the relative importance of the two LXRs in atheroprotection is incompletely understood. We show here that LXRα, the dominant LXR isotype expressed in live
Externí odkaz:
https://doaj.org/article/ff30e527bbf84aa4bcabb5bb64d96c53
Autor:
Xuebing Feng, Hongyun Li, Alexis A. Rumbin, Xuping Wang, Antonio La Cava, Katherine Brechtelsbauer, Lawrence W. Castellani, Joseph L. Witztum, Aldons J. Lusis, Betty P. Tsao
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 4, Pp 794-805 (2007)
To establish a mouse model of accelerated atherosclerosis in lupus, we generated apolipoprotein E-deficient (apoE−/−) and Faslpr/lpr (Fas−/−) C57BL/6 mice. On a normal chow diet, 5 month old apoE−/−Fas−/− mice had enlarged glomerular
Externí odkaz:
https://doaj.org/article/f0a451837ed84ec1868861f271a8d9f2
Autor:
Simon T Hui, Brian W Parks, Elin Org, Frode Norheim, Nam Che, Calvin Pan, Lawrence W Castellani, Sarada Charugundla, Darwin L Dirks, Nikolaos Psychogios, Isaac Neuhaus, Robert E Gerszten, Todd Kirchgessner, Peter S Gargalovic, Aldons J Lusis
Publikováno v:
eLife, Vol 4 (2015)
To identify genetic and environmental factors contributing to the pathogenesis of non-alcoholic fatty liver disease, we examined liver steatosis and related clinical and molecular traits in more than 100 unique inbred mouse strains, which were fed a
Externí odkaz:
https://doaj.org/article/5f9ce024631843678500e7d03cc8bbb4
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 7, Pp 1366-1377 (2006)
Myeloperoxidase (MPO) is an oxidant-generating enzyme present in macrophages at atherosclerotic lesions and implicated in coronary artery disease (CAD). Although mouse models are important for investigating the role of MPO in atherosclerosis, neither
Externí odkaz:
https://doaj.org/article/8d669045b3ef4657b40d249aadad58c2
Autor:
Sonal S. Sheth, Lawrence W. Castellani, Soumya Chari, Cory Wagg, Christopher K. Thipphavong, Jackie S. Bodnar, Peter Tontonoz, Alan D. Attie, Gary D. Lopaschuk, Aldons J. Lusis
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 1, Pp 123-134 (2005)
Through a positional cloning approach, the thioredoxin-interacting protein gene (Txnip) was recently identified as causal for a form of combined hyperlipidemia in mice (Bodnar, J. S., A. Chatterjee, L. W. Castellani, D. A. Ross, J. Ohmen, J. Cavalcol
Externí odkaz:
https://doaj.org/article/c39a4c3809244d358e1825b60f9f7314
Autor:
Lawrence W. Castellani, Peter Gargalovic, Maria Febbraio, Sarada Charugundla, Ming-Len Jien, Aldons J. Lusis
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 12, Pp 2377-2387 (2004)
We previously demonstrated that transgenic mice overexpressing mouse apolipoprotein A-II (apoA-II) exhibit several traits associated with the insulin resistance (IR) syndrome, including increased atherosclerosis, hypertriglyceridemia, obesity, and IR
Externí odkaz:
https://doaj.org/article/390913d425e547d0800bc73392a84ee9
Autor:
Maria C. de Beer, Lawrence W. Castellani, Lei Cai, Arnold J. Stromberg, Frederick C. de Beer, Deneys R. van der Westhuyzen
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 4, Pp 706-715 (2004)
The class B scavenger receptors SR-BI and CD36 exhibit a broad ligand binding specificity. SR-BI is well characterized as a HDL receptor that mediates selective cholesteryl ester uptake from HDL. CD36, a receptor for oxidized LDL, also binds HDL and
Externí odkaz:
https://doaj.org/article/583f3c19afdf479cb0ec5afef3d4fded
Autor:
Ryoko Okamoto, Sigal Gery, Adrian F Gombart, Xuping Wang, Lawrence W Castellani, Tadayuki Akagi, Shuang Chen, Moshe Arditi, Quoc Ho, Aldons J Lusis, Quanlin Li, H Phillip Koeffler
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85341 (2014)
The CCAAT/enhancer binding proteins (C/EBPs) are transcription factors involved in hematopoietic cell development and induction of several inflammatory mediators. C/EBPε is expressed only in myeloid cells including monocytes/macrophages. Atheroscler
Externí odkaz:
https://doaj.org/article/a0f767b34e7e42c9ae4630ef2b72ad4f
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 4, Pp 563-570 (2001)
Studies with mice have revealed that increased expression of apolipoprotein A-II (apoA-II) results in elevations in high density lipoprotein (HDL), the formation of larger HDL, and the development of early atherosclerosis. We now show that the increa
Externí odkaz:
https://doaj.org/article/27268df6ed784e40916863edc583e473
Autor:
Margarete Mehrabian, Lawrence W. Castellani, Ping-Zi Wen, Jack Wong, Tat Rithaporn, Susan Y. Hama, Gregory P. Hough, David Johnson, John J. Albers, Giuliano A. Mottino, Joy S. Frank, Mohamad Navab, Alan M. Fogelman, Aldons J. Lusis
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 12, Pp 1936-1946 (2000)
Strain CAST/Ei (CAST) mice exhibit unusually low levels of high density lipoproteins (HDL) as compared with most other strains of mice, including C57BL/6J (B6). This appears to be due in part to a functional deficiency of lecithin:cholesterol acyltra
Externí odkaz:
https://doaj.org/article/306b4bc1b7fa4004951a999f20acaf6f