Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lawrence T, Feldman"'
Publikováno v:
Journal of Virology. 71:6714-6719
The latency-associated transcript (LAT) promoter of herpes simplex virus type 1 (HSV-1) is unique among the many promoters on the viral genome in that it remains active during the latent state. We have previously shown that a DNA fragment comprising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5424f381c9bddd900cf9a359f9170c1f
https://doi.org/10.1128/jvi.71.9.6714-6719.1997
https://doi.org/10.1128/jvi.71.9.6714-6719.1997
Autor:
Aiko Tan, Lawrence T. Feldman, Nigel T. Maidment, David C. Bloom, Jack G. Stevens, Vivian B. Dissette
Publikováno v:
Molecular Brain Research. 31:48-60
A problem in utilizing herpes simplex virus (HSV) as a vector for expression of foreign genes in CNS neurons has been the inability to facilitate long-term expression of the engineered genes. Previously, we showed that the murine moloney leukemia vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6bfeb00cb45bd06b5cf42cd987aa0a
https://doi.org/10.1016/0169-328x(95)00031-m
https://doi.org/10.1016/0169-328x(95)00031-m
Publikováno v:
Journal of Neurovirology. 1:259-267
One problem in devising strategies of gene transfer to the nervous system is targeting specific neuronal populations. To evaluate the potential for using herpes simplex virus (HSV) as a vector for gene transfer to spinal cord motor neurons, the HSV-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fefad8cbf68dda36780f4db947b392
https://doi.org/10.3109/13550289509114022
https://doi.org/10.3109/13550289509114022
Publikováno v:
Journal of Virology. 68:7148-7158
The ability to direct foreign gene expression from the herpes simplex virus type 1 (HSV-1) genome during an acute or latent infection is a subject of increasing importance in the utilization of HSV vectors for gene therapy. Little is known about the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1558cb7a5efae92d892cc16be2a48751
https://doi.org/10.1128/jvi.68.11.7148-7158.1994
https://doi.org/10.1128/jvi.68.11.7148-7158.1994
Publikováno v:
Journal of Virology. 68:5337-5343
It has been previously reported that the latency-associated transcript (LAT) promoter contains a DNA sequence at the LAT transcription start site which resembles the ICP4 consensus DNA binding site and that this site allows ICP4-mediated downregulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1473a12364c2e7a081f77e50a4b08699
https://doi.org/10.1128/jvi.68.9.5337-5343.1994
https://doi.org/10.1128/jvi.68.9.5337-5343.1994
Autor:
Lawrence T. Feldman
Publikováno v:
Seminars in Virology. 5:207-212
Transcription of the genome of HSV-1 during latency is limited to a single transcription unit of 8.3 kb. From this primary transcript two 3′ co-terminal introns are spliced. The promoter for this transcription unit contains possible neuronal as wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c92686a6327f2a477cae25d6a5c4423
https://doi.org/10.1006/smvy.1994.1022
https://doi.org/10.1006/smvy.1994.1022
Publikováno v:
Virology. 189:150-160
Pathways of viral gene expression were investigated during the acute phase of sensory ganglionic infection with HSV-1. To facilitate these studies we constructed KOS/62-3, an HSV-1 vector in which the Escherichia coli lac-Z gene was inserted behind b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1081068adabc4f19395cc00f000f6518
https://doi.org/10.1016/0042-6822(92)90690-q
https://doi.org/10.1016/0042-6822(92)90690-q
Publikováno v:
Journal of neurovirology. 13(1)
Herpes simplex virus type 1 (HSV-1) primarily infects mucoepithelial tissues of the eye, the orofacial region, and to a lesser extent the genitalia. The virus is retrogradely transported through the axons of sensory and sympathetic neurons to their c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d445a3298d86886e6548acf4012a2e
https://pubmed.ncbi.nlm.nih.gov/17454449
https://pubmed.ncbi.nlm.nih.gov/17454449
Autor:
Lawrence T, Feldman
Publikováno v:
International review of neurobiology. 55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c93d7730bd3a9e491ec2a301aca63117
https://pubmed.ncbi.nlm.nih.gov/12968532
https://pubmed.ncbi.nlm.nih.gov/12968532