Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Lawrence T, Bish"'
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23818 (2011)
Myostatin is a negative regulator of skeletal muscle mass whose activity is upregulated in adult heart failure (HF); however, its role in congenital heart disease (CHD) is unknown.We studied myostatin and IGF-1 expression via Western blot in cardiac
Externí odkaz:
https://doaj.org/article/edfa671eb047403ab72861c7a8066eca
Autor:
Lawrence T Bish, Mark Yarchoan, Meg M Sleeper, Jeffrey A Gazzara, Kevin J Morine, Pedro Acosta, Elisabeth R Barton, H Lee Sweeney
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20856 (2011)
Duchenne muscular dystrophy (DMD) is a degenerative disorder affecting skeletal and cardiac muscle for which there is no effective therapy. Angiotension receptor blockade (ARB) has excellent therapeutic potential in DMD based on recent data demonstra
Externí odkaz:
https://doaj.org/article/dd9d30e4e2ae4bbe8b03695216c160a3
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10230 (2010)
Myostatin is well established as a negative regulator of skeletal muscle growth, but its role in the heart is controversial. Our goal in this study was to characterize myostatin regulation following cardiomyocyte stress and to examine the role of myo
Externí odkaz:
https://doaj.org/article/8bc320743c3540ebbacd3809aeb2f033
Autor:
Kevin J Morine, Lawrence T Bish, Klara Pendrak, Meg M Sleeper, Elisabeth R Barton, H Lee Sweeney
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9176 (2010)
Myostatin inhibition is a promising therapeutic strategy to maintain muscle mass in a variety of disorders, including the muscular dystrophies, cachexia, and sarcopenia. Previously described approaches to blocking myostatin signaling include injectio
Externí odkaz:
https://doaj.org/article/c82d615db8c641b4933c0ebbf297da65
Autor:
Janelle M. Spinazzola, Krista Vandenborne, Glenn A. Walter, Sean C. Forbes, Elisabeth R. Barton, Celine Baligand, H.L. Sweeney, Fan Ye, Lawrence T. Bish, D Plant
Publikováno v:
Gene therapy
In this study, we tested the feasibility of non-invasively measuring phosphoarginine (PArg) after gene delivery of arginine kinase (AK) using an adeno-associated virus (AAV) to murine hindlimbs. This was achieved by evaluating the time course, region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3976b78c40910b53879a7949e6f37a36
http://europepmc.org/articles/PMC3975678
http://europepmc.org/articles/PMC3975678
Autor:
Margaret M. Sleeper, Lawrence T. Bish, Kevin J. Morine, Gretchen E. Singletary, Glenn A. Walter, Dennis J. Trafny, Caryn A. Reynolds, Krista Vandenborne, Janet R. Bogan, Jennifer Pham, H. Lee Sweeney, Joe N. Kornegay, Sean C. Forbes
Publikováno v:
Human Gene Therapy. 22:1499-1509
Duchenne muscular dystrophy (DMD) is a lethal, X-linked recessive disease affecting 1 in 3,500 newborn boys for which there is no effective treatment or cure. One novel strategy that has therapeutic potential for DMD is inhibition of myostatin, a neg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c14c397112e5326e18467627c75226
https://doi.org/10.1089/hum.2011.102
https://doi.org/10.1089/hum.2011.102
Autor:
Xin Mu, H. Lee Sweeney, Margaret M. Sleeper, Lawrence T. Bish, Guangping Gao, Jiachuan Duan, Li Wang, You Lou, Lan Sun, Chunyan Hu
Publikováno v:
Human Gene Therapy. 22:979-984
Heart disease is the leading cause of morbidity and mortality, and cardiac gene transfer has potential as a novel therapeutic approach. We previously demonstrated safe and efficient gene transfer to the canine heart using a percutaneous transendocard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7341f94ea69d818de97bba0f14f30a
https://doi.org/10.1089/hum.2011.042
https://doi.org/10.1089/hum.2011.042
Autor:
Lawrence T. Bish, James M. Wilson, Margaret M. Sleeper, Guangping Gao, Jeffrey Gazzara, Katherine A. High, Elanor Withnall, Caryn A. Reynolds, George Buchlis, H. Lee Sweeney, Gretchen E. Singletary, Daniel Hui
Publikováno v:
Human Gene Therapy. 22:969-977
Derangements in calcium cycling have been described in failing hearts, and preclinical studies have suggested that therapies aimed at correcting this defect can lead to improvements in cardiac function and survival. One strategy to improve calcium cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206dd3b38adfd77fd95e0b3f600b2547
https://doi.org/10.1089/hum.2011.035
https://doi.org/10.1089/hum.2011.035
Autor:
Joshua T. Selsby, Se-Jin Lee, Meg M. Sleeper, H. Lee Sweeney, Kevin J. Morine, Klara Pendrak, Jeffery A. Gazzara, Lawrence T. Bish, Elisabeth R. Barton
Publikováno v:
Muscle & Nerve. 42:722-730
Modulation of transforming growth factor-β (TGF-β) signaling to promote muscle growth holds tremendous promise for the muscular dystrophies and other disorders involving the loss of functional muscle mass. Previous studies have focused on the TGF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7fb669734ed62e6fc37d4da204addba
https://doi.org/10.1002/mus.21743
https://doi.org/10.1002/mus.21743
Publikováno v:
Veterinary Clinics of North America: Small Animal Practice. 40:717-724
Therapeutic gene transfer holds promise as a way to treat dilated cardiomyopathy from any underlying cause because the approach attempts to address metabolic disturbances that occur at the molecular level of the failing heart. Calcium-handling abnorm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a127489f0a1fd3ee15a240f02f82ed
https://doi.org/10.1016/j.cvsm.2010.03.005
https://doi.org/10.1016/j.cvsm.2010.03.005