Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lawrence Szewczuk"'
Autor:
Shannon Dallas, Thomas Wilde, Avijit Ghosh, Jianyao Wang, Yawei Dong, Gaochao Tian, Daohong Liao, Xueliang Li, Lawrence Szewczuk, Peter King, David C. Evans, Yifan Shi, Kurtis E. Bachman, Javier Suarez, Beth Pietrak, James P. Edwards, Carlo Sensenhauser, Hao Chen, Vineet Pande, Peter J. Connolly, Karen DiLoreto, William G Bonnette, Shefali Patel, Zhuming Zhang
Publikováno v:
Journal of Medicinal Chemistry. 64:11570-11596
Selective cyclooxygenase (COX)-2 inhibitors have been extensively studied for colorectal cancer (CRC) chemoprevention. Celecoxib has been reported to reduce the incidence of colorectal adenomas and CRC but is also associated with an increased risk of
Autor:
Michael R. Brandt, Pascal Bonaventure, Christine Dugovic, William G Bonnette, Lawrence Szewczuk, Ryan M Wyatt, Kristen M. Chevalier, Timothy W. Lovenberg, Brian Lord, Tatiana Koudriakova, Allison White, Ian Fraser, Peter J. Connolly, Kay Ahn, Michelle Wennerholm, Javier Suarez, Sujin Yun, Steven W. Sutton, Brahma Ghosh, Natalie Welty, Leslie Nguyen, Bin Zhu, Sui-Po Zhang, Gaochao Tian, Mark J. Macielag, Michael K. Ameriks, Christopher M. Flores
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 372:339-353
The serine hydrolase monoacylglycerol lipase (MAGL) is the rate-limiting enzyme responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) into arachidonic acid and glycerol. Inhibition of 2-AG degradation leads to elevation
Autor:
Frederik J. Rombouts, Lento William, Ingrid Velter, Ann Vos, Aldo Peschiulli, Reuillon Tristan, Maria Dominguez Blanco, Matthieu Jouffroy, Lisa McQueen, Helena Steyvers, Mariette Bekkers, Cristina Altrocchi, Beth Pietrak, Seong Joo Koo, Lawrence Szewczuk, David Walker, Kathryn Packman, Ruud Bueters, Petra Vinken, Amy Johnson, Ricardo Attar, Ulrike Philippar
Publikováno v:
Cancer Research. 82:2133-2133
Appropriate control of cell death is a fundamental biological process which is frequently dysregulated during tumor development and therapeutic resistance. Apoptosis is a form of regulated cell death initiated by either the extracellular environment
Autor:
Dennis S. Yamashita, Christopher S. Brook, Lawrence Szewczuk, David G. Tew, Thaddeus A. Tomaszek, Xiaoyang Dong, Daniel F. Veber, Hye-Ja Oh
Publikováno v:
Journal of Combinatorial Chemistry. 1:207-215
To more rapidly prepare members of the 1,3-bis(acylamino)-2-butanone class of cysteine protease inhibitors, a solid-phase synthesis was developed. 1-Azido-3-amino-2,2-dimethoxybutane (4), which has the two amino groups differentiated and the ketone p
Autor:
Thomas Joseph Carr, Mary J. Bossard, Alison M. Badger, Thaddeus A. Tomaszek, Fred H. Drake, Mark Alan Levy, Lawrence Szewczuk, Scott K. Thompson, Ian E. James, Bartholomew J. Votta, Daniel F. Veber, Maxine Gowen, Janice R. Connor, R.A. Dodds, Bradbeer Jeremy N
Publikováno v:
Journal of Bone and Mineral Research. 12:1396-1406
We have shown previously that cathepsin K, a recently identified member of the papain superfamily of cysteine proteases, is expressed selectively in osteoclasts and is the predominant cysteine protease in these cells. Based upon its abundant cell typ