Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Lawrence Segal"'
Autor:
Martijn Rooseboom, Neslihan Aygun Kocabas, Colin North, Richard James Radcliffe, Lawrence Segal
Publikováno v:
Regulatory Toxicology and Pharmacology. 141:105387
Autor:
Colin M. North, Martijn Rooseboom, Neslihan Aygun Kocabas, Nicholas Synhaeve, Richard James Radcliffe, Lawrence Segal
Publikováno v:
Regulatory Toxicology and Pharmacology. 140:105380
Publikováno v:
Toxicology Reports, Vol 5, Iss, Pp 531-541 (2018)
Toxicology Reports
Toxicology Reports
Highlights • The potential systemic toxicity and mutagenicity of Oligopin®, a French Maritime Pine Bark extract, was evaluated. • Oligopin® was nongenotoxic in both bacterial and human cell assays. • Oligopin® was not acutely toxic and 90 da
Autor:
Lawrence Segal, Eric Destexhe, Karen Thacker, Nathalie Garçon, Michel Fochesato, Giulia Giordano
Publikováno v:
Reproductive Toxicology. 69:297-307
The herpes zoster subunit vaccine (HZ/su) is an investigational vaccine for the prevention of shingles, a disease caused by the varicella zoster virus (VZV). It is composed of recombinant VZV glycoprotein E (gE) and AS01. We assessed the potential to
Autor:
Lawrence Segal, Eric Destexhe, Nathalie Garçon, Marcel V.W. Wijnands, Menk K. Prinsen, Giulia Giordano
Publikováno v:
Journal of Applied Toxicology. 37:132-141
HZ/su is an investigational recombinant subunit vaccine for the prevention of shingles, a disease resulting from the reactivation of varicella zoster virus. The vaccine is composed of recombinant varicella zoster virus glycoprotein E (gE), and liposo
Autor:
Catherine Gérard, Nathalie Garçon, Roy Forster, C. F. Kuper, Nathalie Baudson, Lawrence Segal, J. Silvano
Publikováno v:
Journal of Applied Toxicology
Combination of tumor antigens with immunostimulants is a promising approach in cancer immunotherapy. We assessed animal model toxicity of AS15 combined with various tumor antigens: WT1 (rabbits), or p501, dHER2 and recPRAME (cynomolgus monkeys), admi
Publikováno v:
Journal of Applied Toxicology. 35:1577-1585
The human papillomavirus (HPV)-16/18 vaccine (Cervarix®) is a prophylactic vaccine for the prevention of cervical cancer. The vaccine contains recombinant virus-like particles assembled from the L1 major capsid proteins of the cervical cancer-causin
Autor:
Julien Le Gal, Thomas Martin, Gaëlle Gautier, Eric Destexhe, Frieke Kuper, Lawrence Segal, Danielle Morelle, Arnaud M. Didierlaurent, Sandrine Wouters, Nathalie Garçon
Publikováno v:
Journal of Applied Toxicology. 35:1564-1576
Pandemic-influenza vaccines containing split-inactivated-virus antigen have been formulated with the immunostimulatory Adjuvant System AS03 to enhance the antigen immunogenicity and reduce antigen content per dose. AS03 is an oil-in-water emulsion co
Autor:
Eric Destexhe, Lawrence Segal, R. Forster, N. Baudson, Nathalie Garçon, Diane Stannard, Owen K. Wilby, C.M. Gérard, E. Grosdidier
Publikováno v:
Reproductive Toxicology. 51:90-105
We assessed potential toxic effects of the MAGE-A3 Cancer Immunotherapeutic on female fertility and embryo-fetal, pre- and post-natal development in rats and on male fertility in rats and monkeys. Three groups of 48 female (Study 1) or 22 male (Study