Zobrazeno 1 - 10
of 508
pro vyhledávání: '"Lawrence S. Wilkinson"'
Autor:
Josephine E. Haddon, Daniel Titherage, Julia R. Heckenast, Jennifer Carter, Michael J. Owen, Jeremy Hall, Lawrence S. Wilkinson, Matthew W. Jones
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Impaired behavioural flexibility is a core feature of neuropsychiatric disorders and is associated with underlying dysfunction of fronto-striatal circuitry. Reduced dosage of Cyfip1 is a risk factor for neuropsychiatric disorder, as evidence
Externí odkaz:
https://doaj.org/article/ff9feaf84b2d4dadb10bfac41d15a835
Autor:
Niels Haan, Laura J. Westacott, Jenny Carter, Michael J. Owen, William P. Gray, Jeremy Hall, Lawrence S. Wilkinson
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Genetic risk factors can significantly increase chances of developing psychiatric disorders, but the underlying biological processes through which this risk is effected remain largely unknown. Here we show that haploinsufficiency of Cyfip1,
Externí odkaz:
https://doaj.org/article/b757f4e27d1649beb2573520696f2160
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
We now know that the immune system plays a major role in the complex processes underlying brain development throughout the lifespan, carrying out a number of important homeostatic functions under physiological conditions in the absence of pathologica
Externí odkaz:
https://doaj.org/article/b06a0d27788242f8af8b4ea24bb5ecbf
Autor:
Ana I. Silva, Josephine E. Haddon, Yasir Ahmed Syed, Simon Trent, Tzu-Ching E. Lin, Yateen Patel, Jenny Carter, Niels Haan, Robert C. Honey, Trevor Humby, Yaniv Assaf, Michael J. Owen, David E. J. Linden, Jeremy Hall, Lawrence S. Wilkinson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
People with a genetic deletion of the 15q11.2 locus are at increased risk for psychiatric disorders and white matter disturbances, but the gene(s) responsible are unclear. Here, the authors show that low dosage of CYFIP1, present in the human 15q11.2
Externí odkaz:
https://doaj.org/article/411296870f6b40bf8e1be35dea45f741
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 2, Iss 3, Pp 190-199 (2015)
Turner syndrome (TS), most frequently caused by X-monosomy (45,X), is characterized in part by cardiovascular abnormalities, including aortopathy and bicuspid aortic valve (BAV). There is a need for animal models that recapitulate the cardiovascular
Externí odkaz:
https://doaj.org/article/0764d810f382416aac9b5dcc306a034c
Autor:
Ana I. Silva, Friederike Ehrhart, Magnus O. Ulfarsson, Hreinn Stefansson, Kari Stefansson, Lawrence S. Wilkinson, Jeremy Hall, David E.J. Linden
Publikováno v:
Biological Psychiatry. 92:341-361
Genomic copy number variants (CNVs) are associated with a high risk of neurodevelopmental disorders. A growing body of genetic studies suggests that these high-risk genetic variants converge in common molecular pathways, and that common pathways also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd424cf8639cf3c8e2bb6f35d3c05eca
https://doi.org/10.1016/j.biopsych.2022.03.018
https://doi.org/10.1016/j.biopsych.2022.03.018
Autor:
Nicholas E Clifton, Matthew L Bosworth, Niels Haan, Elliott Rees, Peter A Holmans, Lawrence S Wilkinson, Anthony R Isles, Mark O Collins, Jeremy Hall
Large-scale genomic studies of schizophrenia implicate genes involved in the epigenetic regulation of transcription by histone methylation and genes encoding components of the synapse. However, the interactions between these pathways in conferring ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7af540f88367548341152f9659cbc7
https://orca.cardiff.ac.uk/id/eprint/149622/2/HMG-20~1.PDF
https://orca.cardiff.ac.uk/id/eprint/149622/2/HMG-20~1.PDF
Autor:
Birger Scholz, Amie N Doidge, Philip Barnes, Jeremy Hall, Lawrence S Wilkinson, Kerrie L Thomas
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0153102 (2016)
We investigated the distinctiveness of gene regulatory networks in CA1 associated with the extinction of contextual fear memory (CFM) after recall using Affymetrix GeneChip Rat Genome 230 2.0 Arrays. These data were compared to previously published r
Externí odkaz:
https://doaj.org/article/85af7e2044f0420e824f0c6638cc39e6
Publikováno v:
Frontiers in neuroscience. 16
We now know that the immune system plays a major role in the complex processes underlying brain development throughout the lifespan, carrying out a number of important homeostatic functions under physiological conditions in the absence of pathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d3f2db5ea8ef02bb95010f37de8b87
https://pubmed.ncbi.nlm.nih.gov/35600620
https://pubmed.ncbi.nlm.nih.gov/35600620
A number of studies implicate the loss of function (LoF) mutations affecting the histone methyl transferase SETD1A in the aetiology of a range of neurodevelopmental disorders including schizophrenia. Here, we examined the behavioural consequences of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08250e1f9cd5a3d81dac42a6fb925e98
https://doi.org/10.1101/2021.12.10.471949
https://doi.org/10.1101/2021.12.10.471949