Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Lawrence S. Olanoff"'
Autor:
James M. Anderson, Lawrence S. Olanoff
Publikováno v:
Medical Applications of Controlled Release ISBN: 9780429276620
Sustained and/or controlled release of biological agents is a concept that has received a great deal of attention during the past decade. Systems designed to release drugs at a rate directly influenced by the nature of their surrounding environment w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07e30c8b70891ce5abc897551467678b
https://doi.org/10.1201/9780429276620-11
https://doi.org/10.1201/9780429276620-11
Autor:
Steven R. Pollock, Lawrence S. Olanoff
Publikováno v:
Journal of Controlled Release. 11:331-341
Clinical pharmacology evaluation plays a unique and vital role in the design of novel drug delivery systems. The purpose of this review is to describe how clinical pharmacology principles and methodologies can be applied to the study and development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45ee54cc41caf6e6f04e3512567cfa14
https://doi.org/10.1016/0168-3659(90)90145-j
https://doi.org/10.1016/0168-3659(90)90145-j
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 92:88-91
The patency rate of internal mammary artery grafts is reported to be better than that of saphenous vein grafts in myocardial revascularization operations. To identify a possible biochemical explanation for this phenomenon, we studied the production o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9c437d76766558ead53eaae746162cd
https://doi.org/10.1016/s0022-5223(19)35935-5
https://doi.org/10.1016/s0022-5223(19)35935-5
Publikováno v:
Journal of Pharmaceutical Sciences. 68:1147-1150
A membrane-controlled drug delivery device was developed to release tetracycline at zero-order rates. The tetracycline delivery vehicle is a trilaminate disk consisting of core and coating membranes fabricated from a series of 2-hydroxyethyl methacry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa74bc0b4fc5e4c7825efc9ca8d4de1
https://doi.org/10.1002/jps.2600680924
https://doi.org/10.1002/jps.2600680924
Publikováno v:
British Journal of Clinical Pharmacology. 22:317-323
The objective of this study was to determine the relationships between the total oral clearance of propranolol and the partial clearances through its primary metabolic pathways, i.e. glucuronidation, side-chain oxidation and ring oxidation. Seven you
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c87bbde92f4cb3ced94875574bf633
https://doi.org/10.1111/j.1365-2125.1986.tb02893.x
https://doi.org/10.1111/j.1365-2125.1986.tb02893.x
Autor:
Richard E. Gibson, Lawrence S. Olanoff
Publikováno v:
Journal of Controlled Release. 6:361-366
Intranasal absorption has been demonstrated for various drugs, including peptidic compounds, under a wide range of delivery conditions. However, little is known of the physicochemical nature of the nasal mucosal membrane and how specific changes in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65f8b0ec8d8a11bc6627a53b90b16cc3
https://doi.org/10.1016/0168-3659(87)90089-7
https://doi.org/10.1016/0168-3659(87)90089-7
Publikováno v:
Clinical Pharmacology and Therapeutics. 44:225-231
The buccal absorption of flurbiprofen was studied in normal men to quantify the transport from the oral cavity in humans and to evaluate the closed—perfusion cell apparatus as a means to study drug transport across externally accessible biologic me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebe753fa19a1c3da0de0262c1f7b00c
https://doi.org/10.1038/clpt.1988.141
https://doi.org/10.1038/clpt.1988.141
Autor:
Perry V. Halushka, Lawrence S. Olanoff, H. David Reines, Mitchell F. Hollon, Thomas M. Fuhrman
Publikováno v:
Journal of Surgical Research. 42:284-289
Metabolites of arachidonic acid, particularly thromboxanes, have been implicated as mediators of lung injury. The formation of thromboxane A2 can be decreased by glucocorticoid steroids by inhibiting the enzyme phospholipase A2 or by ibuprofen which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae04ef122c4403f645b9621589948c5
https://doi.org/10.1016/0022-4804(87)90145-4
https://doi.org/10.1016/0022-4804(87)90145-4
Publikováno v:
Clinical Pharmacology and Therapeutics. 37:391-395
Levels of thromboxane B2 (TxB2), the stable metabolite of thromboxane A2, are elevated in human and experimental septic shock. The thromboxane synthetase inhibitor dazoxiben has improved survival and decreased pulmonary hypertension in experimental e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dda86934fdbcd73dc14851adabdbabd
https://doi.org/10.1038/clpt.1985.60
https://doi.org/10.1038/clpt.1985.60
Publikováno v:
Clinical Pharmacology and Therapeutics. 35:755-761
Our objective was to determine the kinetics of (+)- and (-)-propranolol after intravenous doses of racemic drug. Five normal subjects received 0.1 mg/kg of a pseudoracemate of propranolol that consisted of deuterium-labeled (+)-propranolol and unlabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9a97d12b63bbbeba6a98bc4e05c427
https://doi.org/10.1038/clpt.1984.107
https://doi.org/10.1038/clpt.1984.107