Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Lawrence S. Hon"'
Autor:
Lawrence S. Honig, Marwan N. Sabbagh, Christopher H. van Dyck, Reisa A. Sperling, Steven Hersch, Andre Matta, Luigi Giorgi, Michelle Gee, Michio Kanekiyo, David Li, Derk Purcell, Shobha Dhadda, Michael Irizarry, Lynn Kramer
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/235d44fcb4a64fba89f8c186629bc9ac
Autor:
Douglas Galasko, Martin R. Farlow, Brendan P. Lucey, Lawrence S. Honig, Donald Elbert, Randall Bateman, Jeremiah Momper, Ronald G. Thomas, Robert A. Rissman, Judy Pa, Vahan Aslanyan, Archana Balasubramanian, Tim West, Maria Maccecchini, Howard H. Feldman
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Amyloid beta protein (Aβ) is a treatment target in Alzheimer’s Disease (AD). Lowering production of its parent protein, APP, has benefits in preclinical models. Posiphen, an orally administered small molecule, binds to an iron-
Externí odkaz:
https://doaj.org/article/e42d62be4d5d45feab248f4b5d8078a5
Autor:
Hsin-Pei Wang, Rebeca Scalco, Naomi Saito, Laurel Beckett, My-Le Nguyen, Emily Z. Huie, Lawrence S. Honig, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Dan M. Mungas, Lee-Way Jin, Brittany N. Dugger
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract Cerebrovascular and α-synuclein pathologies are frequently observed alongside Alzheimer disease (AD). The heterogeneity of AD necessitates comprehensive approaches to postmortem studies, including the representation of historically underrep
Externí odkaz:
https://doaj.org/article/2ccca9693bd8481a91ee168a49211a38
Autor:
Lawrence S. Honig, Marwan N. Sabbagh, Christopher H. van Dyck, Reisa A. Sperling, Steven Hersch, Andre Matta, Luigi Giorgi, Michelle Gee, Michio Kanekiyo, David Li, Derk Purcell, Shobha Dhadda, Michael Irizarry, Lynn Kramer
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Alzheimer disease (AD) is a major health problem of aging, with tremendous burden on healthcare systems, patients, and families globally. Lecanemab, an FDA-approved amyloid beta (Aβ)-directed antibody indicated for the treatment
Externí odkaz:
https://doaj.org/article/37323811cfca4e539a625fdbaee2b067
Autor:
Rebeca Scalco, Naomi Saito, Laurel Beckett, My-Le Nguyen, Emily Huie, Hsin-Pei Wang, Delaney A. Flaherty, Lawrence S. Honig, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Lee-Way Jin, Brittany N. Dugger
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Despite the increasing demographic diversity of the United States’ aging population, there remain significant gaps in post-mortem research investigating the ethnoracial heterogeneity in the neuropathological landscape of Alzheimer Disease
Externí odkaz:
https://doaj.org/article/c400d7d0dfbe4c4d88b0540088c7067d
Autor:
Shubha Vij, Heiner Kuhl, Inna S. Kuznetsova, Aleksey Komissarov, Andrey A. Yurchenko, Peter Van Heusden, Siddharth Singh, Natascha M. Thevasagayam, Sai Rama Sridatta Prakki, Kathiresan Purushothaman, Jolly M. Saju, Junhui Jiang, Stanley Kimbung Mbandi, Mario Jonas, Amy Hin Yan Tong, Sarah Mwangi, Doreen Lau, Si Yan Ngoh, Woei Chang Liew, Xueyan Shen, Lawrence S. Hon, James P. Drake, Matthew Boitano, Richard Hall, Chen-Shan Chin, Ramkumar Lachumanan, Jonas Korlach, Vladimir Trifonov, Marsel Kabilov, Alexey Tupikin, Darrell Green, Simon Moxon, Tyler Garvin, Fritz J. Sedlazeck, Gregory W. Vurture, Gopikrishna Gopalapillai, Vinaya Kumar Katneni, Tansyn H. Noble, Vinod Scaria, Sridhar Sivasubbu, Dean R. Jerry, Stephen J. O'Brien, Michael C. Schatz, Tamás Dalmay, Stephen W. Turner, Si Lok, Alan Christoffels, László Orbán
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 12, p e1006500 (2016)
PLoS Genetics, Vol 12, Iss 12, p e1006500 (2016)
We report here the ~670 Mb genome assembly of the Asian seabass (Lates calcarifer), a tropical marine teleost. We used long-read sequencing augmented by transcriptomics, optical and genetic mapping along with shared synteny from closely related fish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb7e13d3681f3c2610a7fb7b430c613
http://europepmc.org/articles/PMC5147801
http://europepmc.org/articles/PMC5147801
Autor:
Ramkumar Lachumanan, Richard Hall, Vinod Scaria, Gregory Vurture, Xueyan Shen, László Orbán, Matthew Boitano, Lawrence S. Hon, Woei Chang Liew, Si Lok, James P Drake, Tamas Dalmay, Dean R. Jerry, Vinaya Kumar Katneni, Junhui Jiang, Alan Christoffels, Andrey A. Yurchenko, Peter van Heusden, Inna S. Kuznetsova, Fritz J. Sedlazeck, Kathiresan Purushothaman, Tyler Garvin, Aleksey Komissarov, Sai Rama Sridatta Prakki, Michael C. Schatz, Amy Hin Yan Tong, Natascha May Thevasagayam, Stephen Turner, Gopikrishna Gopalapillai, Marsel R. Kabilov, Tansyn Noble, Heiner Kuhl, Jonas Korlach, Chen-Shan Chin, Doreen Lau, Stanley Kimbung Mbandi, Vladimir A. Trifonov, Sridhar Sivasubbu, Shubha Vij, Simon Moxon, Siddharth Singh, Darrell Green, Si Yan Ngoh, Jolly M. Saju, Sarah Mwangi, Mario Jonas, Stephen J. O'Brien, Alexey E. Tupikin
Publikováno v:
PLoS Genetics, Vol 12, Iss 4, p e1005954 (2016)
PLoS Genetics
PLoS Genetics
We report here the ~670 Mb genome assembly of the Asian seabass (Lates calcarifer), a tropical marine teleost. We used long-read sequencing augmented by transcriptomics, optical and genetic mapping along with shared synteny from closely related fish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21248b1ffc3909031f0a79b335e50849
https://ueaeprints.uea.ac.uk/id/eprint/58296/
https://ueaeprints.uea.ac.uk/id/eprint/58296/
Publikováno v:
Human Mutation. 30:99-106
Signal peptides are N-terminal sequences that mediate the targeting and translocation of secreted or cell-surface proteins to the endoplasmic reticulum (ER) membrane. Because of the variability among signal peptides, traditional methods for predictin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008a5f1d165c329f65d4ef116ea43f12
https://doi.org/10.1002/humu.20798
https://doi.org/10.1002/humu.20798
Publikováno v:
Current Bioinformatics. 3:46-55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f79c84006388e5a594c241f67ab4eff
https://doi.org/10.2174/157489308783329841
https://doi.org/10.2174/157489308783329841
Publikováno v:
Nucleic Acids Research
GeneHub-GEPIS is a web application that performs digital expression analysis in human and mouse tissues based on an integrated gene database. Using aggregated expressed sequence tag (EST) library information and EST counts, the application calculates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa9fffc45c4f41f27ee3ae0efca4d33
https://doi.org/10.1093/nar/gkm381
https://doi.org/10.1093/nar/gkm381