Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Lawrence Recht"'
Autor:
Jiaxin Sun, Chirag B. Patel, Taichang Jang, Milton Merchant, Chen Chen, Shiva Kazerounian, Anne R. Diers, Michael A. Kiebish, Vivek K. Vishnudas, Stephane Gesta, Rangaprasad Sarangarajan, Niven R. Narain, Seema Nagpal, Lawrence Recht
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Metabolic reprogramming in cancer cells, vs. non-cancer cells, elevates levels of reactive oxygen species (ROS) leading to higher oxidative stress. The elevated ROS levels suggest a vulnerability to excess prooxidant loads leading to selecti
Externí odkaz:
https://doaj.org/article/f351ed5583a042e9aacf892af8e97331
Autor:
Michael C. Jin, Elisa K. Liu, Siyu Shi, Iris C. Gibbs, Reena Thomas, Lawrence Recht, Scott G. Soltys, Erqi L. Pollom, Steven D. Chang, Melanie Hayden Gephart, Seema Nagpal, Gordon Li
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Introduction: Gliosarcomas are clinically aggressive tumors, histologically distinct from glioblastoma. Data regarding the impact of extent of resection and post-operative adjuvant therapy on gliosarcoma outcomes are limited.Methods: Patients with hi
Externí odkaz:
https://doaj.org/article/b511d5907ae4467fa266bc33fed03898
Autor:
Lei Deng, Jason H. Stafford, Shie-Chau Liu, Sophia B. Chernikova, Milton Merchant, Lawrence Recht, J. Martin Brown
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 1, Pp 1-7 (2017)
Despite the approval of antiangiogenic therapy for glioblastoma multiforme (GBM) patients, survival benefits are still limited. One of the resistance mechanisms for antiangiogenic therapy is the induction of hypoxia and subsequent recruitment of macr
Externí odkaz:
https://doaj.org/article/9a063b90518c43ef8b06f0db5778ff48
Autor:
Le Zheng, Yan Zhang, Shiying Hao, Lin Chen, Zhen Sun, Chi Yan, John C Whitin, Taichang Jang, Milton Merchant, Doff B McElhinney, Karl G Sylvester, Harvey J Cohen, Lawrence Recht, Xiaoming Yao, Xuefeng B Ling
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223558 (2019)
Malignant gliomas remain incurable with a poor prognosis despite of aggressive treatment. We have been studying the development of brain tumors in a glioma rat model, where rats develop brain tumors after prenatal exposure to ethylnitrosourea (ENU),
Externí odkaz:
https://doaj.org/article/701ccb93275b4e0a91f755713acd73c4
Autor:
Keshav Datta, Mette H Lauritzen, Milton Merchant, Taichang Jang, Shie-Chau Liu, Ralph Hurd, Lawrence Recht, Daniel M Spielman
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225313 (2019)
BackgroundMetabolism in tumor shifts from oxidative phosphorylation to inefficient glycolysis resulting in overproduction of lactate (Warburg effect), and cancers may be effectively treated if this imbalance were corrected. The aim of this longitudin
Externí odkaz:
https://doaj.org/article/136966632a074d21ad12676d4c066038
Autor:
John C Whitin, Taichang Jang, Milton Merchant, Tom T-S Yu, Kenneth Lau, Benjamin Recht, Harvey J Cohen, Lawrence Recht
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49724 (2012)
BACKGROUND: Understanding the early relationship between brain tumor cells and their environment could lead to more sensitive biomarkers and new therapeutic strategies. We have been using a rodent model of neurocarcinogenesis in which all animals dev
Externí odkaz:
https://doaj.org/article/ff36ab1df69541618698c47897395eeb
Autor:
Mohammed Dar, Dominic W. Lai, Jennifer McDevitt, Matthew Gribbin, Denison Kuruvilla, Thomas Kaley, Vicky Makker, Efrat Dotan, Lawrence Recht, Michael Birrer, Deborah K. Armstrong, Ronald Natale, Naiyer Rizvi, David M. Hyman
SUPPLEMENTARY TABLES Supplementary Table 1. Treatment-emergent grade 3/4 adverse events in the safety population (n=116) Supplementary Table 2. MEDI3617 pharmacokinetic parameters Supplementary Table 3. Treatment outcome: objective response and progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b73097687608e3f3c7d778debbbc10
https://doi.org/10.1158/1078-0432.22465569.v1
https://doi.org/10.1158/1078-0432.22465569.v1
Autor:
Mohammed Dar, Dominic W. Lai, Jennifer McDevitt, Matthew Gribbin, Denison Kuruvilla, Thomas Kaley, Vicky Makker, Efrat Dotan, Lawrence Recht, Michael Birrer, Deborah K. Armstrong, Ronald Natale, Naiyer Rizvi, David M. Hyman
Purpose: This first-in-human study aimed to determine the MTD and safety of MEDI3617, a selective anti–angiopoietin-2 (Ang2) mAb, alone and combined with bevacizumab or cytotoxic chemotherapy.Patients and Methods: This phase I/Ib, multicenter, open
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce3ad3a2b09aeb49cdd59cc67d0dc04
https://doi.org/10.1158/1078-0432.c.6526068.v1
https://doi.org/10.1158/1078-0432.c.6526068.v1
Autor:
Israt S. Alam, Nobuko Uchida, Pauline Chu, Lewis Naya, Melanie Hayden-Gephart, Corinne Beinat, Guido Davidzon, Jessa B. Castillo, Mary Ellen I. Koran, Andrei Iagaru, Geoffrey I. Warnock, Harsh Gandhi, Donald E. Born, Samantha T. Reyes, Jun Hyung Park, Kim Halbert, Michelle L. James, Lawrence Recht, Irving L. Weissman, Dawn Holley, Pablo Buccino, Monica Granucci, Bin Shen, Eli Johnson, Rahul Sinha, Sanjiv S. Gambhir, Daniel Dan Liu, Seema Nagpal, Megan Phillips, Tom Haywood, Mehdi Khalighi, Reena Thomas, Chirag B. Patel, Surya Murty, Tarik F. Massoud, Joy Q He
Publikováno v:
Clinical Cancer Research. 27:6467-6478
Purpose: Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key process of cancer metabolism. PKM2 is preferentially expressed by glioblastoma (GBM) cells with minimal expression in healthy brain. We describe the development, validat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20b211c501bb8334bd352758ee11613b
https://doi.org/10.1158/1078-0432.ccr-21-0544
https://doi.org/10.1158/1078-0432.ccr-21-0544
Autor:
Reena Thomas, Wenying Kang, Melanie Hayden Gephart, Eben L. Rosenthal, Johana C. M. Vega Leonel, Guolan Lu, Quan Zhou, Grace Yi, Gordon Li, Marisa E. Hom, Michael, Lawrence Recht, Monica Granucci, Shannon Walters, Hannes Vogel, Gerald A. Grant, Romain Cayrol, Seema Nagpal, Nynke S. van den Berg, Chirag B. Patel, Roan C Raymundo, Naoki Nishio, Yu-Jin Lee, Michael Zhang
Publikováno v:
Theranostics
Rationale: First-line therapy for high-grade gliomas (HGGs) includes maximal safe surgical resection. The extent of resection predicts overall survival, but current neuroimaging approaches lack tumor specificity. The epidermal growth factor receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3425f6ee1b690b6fa3b96a4768d47f
https://doi.org/10.7150/thno.60582
https://doi.org/10.7150/thno.60582