Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Lawrence R. Phillips"'
Autor:
Chad N. Hancock, Luke H. Stockwin, Dianne L. Newton, Suzanne Borgel, Lawrence R. Phillips, Melinda G. Hollingshead, Sherry X. Yu, Tracy L. Wolfe
Publikováno v:
International Journal of Cancer. 127:2510-2519
The "Warburg effect," also termed aerobic glycolysis, describes the increased reliance of cancer cells on glycolysis for ATP production, even in the presence of oxygen. Consequently, there is continued interest in inhibitors of glycolysis as cancer t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097b01910313800497c30045a96bdfd2
https://doi.org/10.1002/ijc.25499
https://doi.org/10.1002/ijc.25499
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 32:261-272
A gradient reversed-phase high performance liquid chromatographic method was developed for determining NSC 737664 (2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide; ABT-888) in human plasma and urine. Chromatographic separation used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f027abc78b3cadd7ffd6e69b5f7b0ee
https://doi.org/10.1080/10826070802603351
https://doi.org/10.1080/10826070802603351
Autor:
Joel A. Bozue, Lawrence R. Phillips, Itai Mendelson, Arthur M. Friedlander, Avigdor Shafferman, Christopher K. Cote, P.F. Fellows, Narayanan Parthasarathy
Publikováno v:
Microbial Pathogenesis. 38:1-12
Carbohydrate analyses of whole-spore extracts have confirmed the presence of rhamnose in the spore of the fully virulent Ames strain of Bacillus anthracis. A gene cluster containing loci with high homology to the rhamnose biosynthetic genes, rmlACBD,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b156296fa85d981e39afb6cfdaec7a
https://doi.org/10.1016/j.micpath.2004.10.001
https://doi.org/10.1016/j.micpath.2004.10.001
Autor:
Marcin K. Chmielewski, Serge L. Beaucage, Lawrence R. Phillips, Andrzej Grajkowski, Andrzej Wilk
Publikováno v:
Tetrahedron Letters. 42:5635-5639
An efficient and economical method for the solid-phase synthesis of oligodeoxyribonucleotides and their phosphorothioate analogues is described. The method entails the use of the 4-oxopentyl group for phosphate/thiophosphate protection. Post-synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c4cf0b6d8a59e2fd54fb4e4de48f2c0
https://doi.org/10.1016/s0040-4039(01)01094-2
https://doi.org/10.1016/s0040-4039(01)01094-2
Autor:
Marcin K. Chmielewski, Andrzej Grajkowski, Serge L. Beaucage, Lawrence R. Phillips, Andrzej Wilk
Publikováno v:
Organic Letters. 3:1287-1290
[reaction in text] The 2-(N-formyl-N-methyl)aminoethyl deoxyribonucleoside phosphoramidite 1 has been synthesized and used in the solid-phase synthesis of an octadecathymidylic acid as a cost-efficient monomer for potential application in the prepara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b72eb1037ce076189e3a62af0d0c1f
https://doi.org/10.1021/ol0156852
https://doi.org/10.1021/ol0156852
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 23:395-402
Zinc finger motifs have been found to be important in a variety of protein structures including transcription factors and viral nucleocapsid proteins. Recently, it was demonstrated that various aromatic disulfides effectively remove the metal ion fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fc28e153f3d79258880fd05ba47a91
https://doi.org/10.1016/s0731-7085(00)00311-3
https://doi.org/10.1016/s0731-7085(00)00311-3
Autor:
Lawrence R. Phillips, Tyra House, Tracy L. Wolfe, John Buckley, Chris Bramhall, Sherman F. Stinson
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 741:205-211
During the course of our study to develop analytical methodology for quantitating the investigative antitumor agent 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran -4-one (DAF; NSC 686288) in plasma, a significant concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6074a1051c5a6449c8d8ca0d122185
https://doi.org/10.1016/s0378-4347(00)00094-3
https://doi.org/10.1016/s0378-4347(00)00094-3
Publikováno v:
Journal of the American Chemical Society. 122:2149-2156
A simple and straightforward synthesis of the pyrimidine 2‘-deoxyribonucleoside cyclic N-acylphosphoramidites RP-1 and SP-1 is described. Specifically, (±)-2-amino-1-phenylethanol 2 was chemoselect...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98d78b60b635fca976d572f1b340d718
https://doi.org/10.1021/ja991773u
https://doi.org/10.1021/ja991773u
Publikováno v:
The Journal of Organic Chemistry. 64:7515-7522
The 4-[N-methyl-N-(2,2,2-trifluoroacetyl)amino]butyl group for phosphate protection in the synthesis of oligodeoxyribonucleotides has been developed to completely prevent nucleobase alkylation by acrylonitrile that could potentially occur upon deprot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89805f19631a7c3c513b51f7e1ac850b
https://doi.org/10.1021/jo990835w
https://doi.org/10.1021/jo990835w
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 732:315-321
Certain naturally occurring isoflavonoids have been shown to inhibit protein-tyrosine kinases, and this has led to investigations of ring-modified structural analogs. Most recently, 2-(3-methyl-4-aminophenyl)-benzothiazole (MAB: NSC 674495) was shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0691f14568503dba133dfc3b1caa8f2f
https://doi.org/10.1016/s0378-4347(99)00295-9
https://doi.org/10.1016/s0378-4347(99)00295-9