Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Lawrence R. Marcin"'
Autor:
Jeremy H. Toyn, Lorin A. Thompson, Kimberley A. Lentz, Jere E. Meredith, Catherine R. Burton, Sethu Sankaranararyanan, Valerie Guss, Tracey Hall, Lawrence G. Iben, Carol M. Krause, Rudy Krause, Xu-Alan Lin, Maria Pierdomenico, Craig Polson, Alan S. Robertson, R. Rex Denton, James E. Grace, John Morrison, Joseph Raybon, Xiaoliang Zhuo, Kimberly Snow, Ramesh Padmanabha, Michele Agler, Kim Esposito, David Harden, Margaret Prack, Sam Varma, Victoria Wong, Yingjie Zhu, Tatyana Zvyaga, Samuel Gerritz, Lawrence R. Marcin, Mendi A. Higgins, Jianliang Shi, Cong Wei, Joseph L. Cantone, Dieter M. Drexler, John E. Macor, Richard E. Olson, Michael K. Ahlijanian, Charles F. Albright
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2014 (2014)
Alzheimer’s disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-β peptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased by γ-secretase modulators (GSM), whi
Externí odkaz:
https://doaj.org/article/1dce320132d4411583a19dcbfe2b54ae
Autor:
John E. Macor, Yunhui Zhang, James E. Grace, Lorin A. Thompson, Jeremy H. Toyn, Lawrence R. Marcin, Subramaniam Krishnananthan, Jianliang Shi, Dmitry Zuev, Daniel Smith, Jianqing Li, Yong-Jin Wu, Jason M. Guernon, Xiaoliang Zhuo, Tatyana Zvyaga, Xu Li, Arvind Mathur, John Morrison, Jere E. Meredith, Charles F. Albright, S. Roy Kimura, Mendi A. Higgins, Kimberley A. Lentz, Richard E. Olson, Rex Denton, Kenneth M. Boy, Catherine R. Burton, Ashok K. Trehan, Michael K. Ahlijanian
Publikováno v:
ACS Medicinal Chemistry Letters
A triazine hit identified from a screen of the BMS compound collection was optimized for potency, in vivo activity, and off-target profile to produce the bicyclic pyrimidine γ-secretase modulator BMS-932481. The compound showed robust reductions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed62d494eee5e78e1c6f0f7838951135
http://europepmc.org/articles/PMC6421538
http://europepmc.org/articles/PMC6421538
Autor:
Mahesh Paschapur, Jeffrey M. Brown, Tanmaya Bastia, Lawrence R. Marcin, Jayakumar Sankara Warrier, Srinivasan Thangathirupathy, Joanne J. Bronson, Raja Reddy Kallem, Huiping Zhang, Jyoti Gulia, Alda Fernandes, Digavalli V. Sivarao, Deborah Keavy, Amy Newton, Jianqing Li, Pattipati S. Naidu, Kuchibhotla Vijaya Kumar, James Kempson, Michael R. Weed, Rick L. Pieschl, Mark Bookbinder, Charlie F. Albright, Kimberly Newberry, Yu-Wen Li, Dalton King, Manjunath Ramarao, Jean Simmermacher, Linda J. Bristow, Meenakshee Sinha, Eric Shields, Lorin A. Thompson, John E. Macor, Charulatha Sanmathi, Imadul Islam, B.N. Srikumar, Richard E. Olson, John D. Graef, Arvind Mathur, Narasimharaju Kalidindi, Joseph Polino, Michael Sinz, Thaddeus F. Molski, Jayant Aher, Reeba K. Vikramadithyan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 363:377-393
(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169) and the phosphate prodrug 4-((3S,4S)-3-fluoro-1-((R)-1-(4-methylbenzyl)-2-oxopyrrolidin-3-yl)piperidin-4-yl)phenyl dihydrogen phosphate (BMS-98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fc12be7607ec5d5401f625fdca24cd2
https://doi.org/10.1124/jpet.117.242784
https://doi.org/10.1124/jpet.117.242784
Autor:
Valerie J. Whiterock, Amy Easton, Regina Miller, Lawrence R. Marcin, Meredith Ferrante, Bradley C. Pearce, John B. Hogan, Joanne J. Bronson, Clotilde Bourin, Mendi A. Higgins, Robert G. Gentles, F. Christopher Zusi, Walter Kostich, John E. Macor, Michael Gulianello, Min Ding, Linda J. Bristow, Adam Hendricson, Kim A. Johnson, Andrew Alt, Yanling Huang, Matthew A. Seager
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:496-513
Triazolopyridine ethers with mGlu2 positive allosteric modulator (PAM) activity are disclosed. The synthesis, in vitro activity, and metabolic stability data for a series of analogs is provided. The effort resulted in the discovery of a potent, selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4fbbfea4e7fe10fc6e8c858a57219bd
https://doi.org/10.1016/j.bmc.2016.11.018
https://doi.org/10.1016/j.bmc.2016.11.018
Autor:
Arvind Mathur, Rajareddy Kallem, Thaddeus F. Molski, Manjunatha Narayana Rao Kamble, Michelle Nophsker, Huiping Zhang, Murali Subramanian, Dalton King, Linda J. Bristow, Lawrence R. Marcin, B.N. Srikumar, Grandhi Venkat Ram Krishna Mohan Gupta, Kumar Kuchibhotla Vijaya, Jayakumar Sankara Warrier, Michael Sinz, Charulatha Sanmathi, G. Nagaraju, Xiaoliang Zhuo, Raju Mannoori, Imadul Islam, Alicia Ng, Pattipati S. Naidu, Eric Shields, Joanne J. Bronson, Narasimharaju Kalidindi, Reeba K. Vikramadithyan, Gopikishan Tonukunuru, Lorin A. Thompson, James Kempson, Srinivasan Thangathirupathy, Jogi Srinivas, Bradley C. Pearce, Jyoti Gulia, Jean Simmermacher, Srinivas Cheruku, Mahesh Paschapur, Jianliang Shi, John E. Macor, Jayant Aher, Manjunath Ramarao, Charlie F. Albright, Richard E. Olson, Rex Denton, Aliphedi B. Reddy, Hyunsoo Park, Karageorge George N, Tanmaya Bastia, Jianqing Li
Publikováno v:
ACS medicinal chemistry letters. 9(5)
[Image: see text] There is a significant unmet medical need for more efficacious and rapidly acting antidepressants. Toward this end, negative allosteric modulators of the N-methyl-d-aspartate receptor subtype GluN2B have demonstrated encouraging the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b5b1329a3adeaa60f04b63eb061394
https://pubmed.ncbi.nlm.nih.gov/29795762
https://pubmed.ncbi.nlm.nih.gov/29795762
Autor:
Linda J, Bristow, Jyoti, Gulia, Michael R, Weed, Bettadapura N, Srikumar, Yu-Wen, Li, John D, Graef, Pattipati S, Naidu, Charulatha, Sanmathi, Jayant, Aher, Tanmaya, Bastia, Mahesh, Paschapur, Narasimharaju, Kalidindi, Kuchibhotla Vijaya, Kumar, Thaddeus, Molski, Rick, Pieschl, Alda, Fernandes, Jeffrey M, Brown, Digavalli V, Sivarao, Kimberly, Newberry, Mark, Bookbinder, Joseph, Polino, Deborah, Keavy, Amy, Newton, Eric, Shields, Jean, Simmermacher, James, Kempson, Jianqing, Li, Huiping, Zhang, Arvind, Mathur, Raja Reddy, Kallem, Meenakshee, Sinha, Manjunath, Ramarao, Reeba K, Vikramadithyan, Srinivasan, Thangathirupathy, Jayakumar, Warrier, Imadul, Islam, Joanne J, Bronson, Richard E, Olson, John E, Macor, Charlie F, Albright, Dalton, King, Lorin A, Thompson, Lawrence R, Marcin, Michael, Sinz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 363(3)
(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd1b2a02de8ae2373f7595e246bd87cd
https://pubmed.ncbi.nlm.nih.gov/28954811
https://pubmed.ncbi.nlm.nih.gov/28954811
Autor:
Mendi A. Higgins, Jianliang Shi, Lawrence R. Marcin, Yong-Jin Wu, Jason M. Guernon, Fukang Yang, Lorin A. Thompson, Lawrence B. Snyder
Publikováno v:
Tetrahedron Letters. 55:2134-2137
A series of β-disubstituted N-sulfinyl β-amino isoxazolyl ketones has been prepared by addition of tert-butanesulfinyl ketimines with the n-BuLi-generated enolates of isoxazolyl methyl ketones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::293c93c3d5dffa2f2afa9596a1316b52
https://doi.org/10.1016/j.tetlet.2014.02.053
https://doi.org/10.1016/j.tetlet.2014.02.053
Autor:
Mendi A, Higgins, Lawrence R, Marcin, F, Christopher Zusi, Robert, Gentles, Min, Ding, Bradley C, Pearce, Amy, Easton, Walter A, Kostich, Matthew A, Seager, Clotilde, Bourin, Linda J, Bristow, Kim A, Johnson, Regina, Miller, John, Hogan, Valerie, Whiterock, Michael, Gulianello, Meredith, Ferrante, Yanling, Huang, Adam, Hendricson, Andrew, Alt, John E, Macor, Joanne J, Bronson
Publikováno v:
Bioorganicmedicinal chemistry. 25(2)
Triazolopyridine ethers with mGlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c51d8b2216df7c3ae7ce8e46554f0338
https://pubmed.ncbi.nlm.nih.gov/27914948
https://pubmed.ncbi.nlm.nih.gov/27914948
Autor:
Thaddeus F. Molski, Ronald J. Mattson, Gail K. Mattson, Qi Gao, Dedong Wu, Lawrence R. Marcin, Nicholas J. Lodge
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1027-1030
Substituted 1-tosyl-3-vinylindoles undergo [3+2] dipolar cycloaddition with cyclic nitrones to afford substituted isoxazoles in good yield and high diastereoselectivity. The cycloadducts were readily converted in 4 steps into ring constrained homotry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cab3271678063be9233a1223cc6e52
https://doi.org/10.1016/j.bmcl.2009.12.043
https://doi.org/10.1016/j.bmcl.2009.12.043
Autor:
Gail K. Mattson, Charles P. Sloan, Matthew T. Taber, Brett R. Beno, Ronald J. Mattson, Melissa A. Cunningham, Qi Gao, Mendi A. Higgins, Nicholas J. Lodge, Thaddeus F. Molski, Jeffrey A. Deskus, Jonathan L. Ditta, Lawrence R. Marcin, John D. Catt, Derek J. Denhart
Publikováno v:
Journal of Medicinal Chemistry. 48:6023-6034
A series of indole cyclopropylmethylamines were found to be potent serotonin reuptake inhibitors. Nitrile substituents at the 5 and 7 positions of the indole ring gave high affinity for hSERT, and the preferred cyclopropane stereochemistry was determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514771b7591736c2884b7eaa83854f2d
https://doi.org/10.1021/jm0503291
https://doi.org/10.1021/jm0503291