Výsledky vyhledávání - "Lawrence R. MacDonald"

Impact of Using Uniform Attenuation Coefficients for Heterogeneously Dense Breasts in a Dedicated Breast PET/X-ray Scanner

Autor: Gregory M. Sturgeon, Lawrence R. MacDonald, Chengeng Zeng, William P. Segars, Paul E. Kinahan, Robert L. Harrison, Joseph Y. Lo

Publikováno v: IEEE Trans Radiat Plasma Med Sci

We investigated PET image quantification when using a uniform attenuation coefficient ( $\mu $ ) for attenuation correction (AC) of anthropomorphic density phantoms derived from high-resolution breast CT scans. A breast PET system was modeled with pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2d06550791ec5b9fb9dd9c005d1d5b
https://europepmc.org/articles/PMC7643852/

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The PET/X dedicated breast-PET scanner for optimizing cancer therapy

Autor: Don DeWitt, Lawrence R. MacDonald, Robert S. Miyaoka, Sergei Dolinski, Larry Pierce, Chengeng Zeng, Paul E. Kinahan, William C. J. Hunter

Publikováno v: IWBI

We are currently building the PET/X scanner, which is a breast positron emission tomography (PET) scanner combined with a standard X-ray mammography system. The role for the PET/X scanner is to precisely measure changes in radiotracer uptake after an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82603203ab4814d26fd3ace9a84f4cb6
https://doi.org/10.1117/12.2318419

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Characterization of highly multiplexed monolithic PET / gamma camera detector modules:Paper

Autor: Stefano Pedemonte, K. Van Leemput, Robert S. Miyaoka, Lawrence R. MacDonald, Don DeWitt, Larry Pierce, William C. J. Hunter

Publikováno v: Pierce, L A, Pedemonte, S, Dewitt, S, Macdonald, L, Hunter, W C J, Leemput, V & Miyaoka, R 2018, ' Characterization of highly multiplexed monolithic PET / gamma camera detector modules : Paper ', Physics in Medicine and Biology, vol. 63, no. 7, 075017 . https://doi.org/10.1088/1361-6560/aab380

PET detectors use signal multiplexing to reduce the total number of electronics channels needed to cover a given area. Using measured thin-beam calibration data, we tested a principal component based multiplexing scheme for scintillation detectors. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece3059111ccc58c31a74ec56b190cb2
https://orbit.dtu.dk/en/publications/c36ff8a2-1f73-414d-b67b-282eb1b9d2b0

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Comparison of prone versus supine 18F-FDG-PET of locally advanced breast cancer: Phantom and preliminary clinical studies

Autor: Lawrence R. MacDonald, Tzu Cheng Lee, Savannah C. Partridge, Hakmook Kang, Sudheer D. Rani, Hannah M. Linden, Xia Li, Jason M. Williams, Paul E. Kinahan, Lori R. Arlinghaus, Jennifer G. Whisenant, Thomas E. Yankeelov, Richard G. Abramson

Publikováno v: Medical Physics. 42:3801-3813

Purpose: Previous studies have demonstrated how imaging of the breast with patients lying prone using a supportive positioning device markedly facilitates longitudinal and/or multimodal image registration. In this contribution, the authors’ primary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::239648400cdea300f36a4604a1d30f66
https://doi.org/10.1118/1.4921363

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Dual energy computed tomography quantification of carotid plaques calcification: comparison between monochromatic and polychromatic energies with pathology correlation

Autor: Lawrence R. MacDonald, Marina S. Ferguson, Lorenzo Di Cesare Mannelli, Marcello Mancini, Serena Monti, Dongxiang Xu, Lee M. Mitsumori, William P. Shuman, Chun Yuan, Monica Ragucci

Publikováno v: European radiology (2014). doi:10.1007/s00330-014-3523-0
info:cnr-pdr/source/autori:Mannelli L.; MacDonald L.; Mancini M.; Ferguson M.; Shuman W.P.; Ragucci M.; Monti S.; Xu D.; Yuan C.; Mitsumori L.M./titolo:Dual energy computed tomography quantification of carotid plaques calcification: comparison between monochromatic and polychromatic energies with pathology correlation/doi:10.1007%2Fs00330-014-3523-0/rivista:European radiology/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume
European radiology 2 (2015): 1238–1246.
info:cnr-pdr/source/autori:Mannelli L, MacDonald L, Mancini M, Ferguson M, Shuman WP, Ragucci M, Monti S, Xu D, Yuan C, Mitsumori LM/titolo:Dual energy computed tomography quantification of carotid plaques calcification: comparison between monochromatic and polychromatic energies with pathology correlation/doi:/rivista:European radiology/anno:2015/pagina_da:1238/pagina_a:1246/intervallo_pagine:1238–1246/volume:2

We compared carotid plaque calcification detection sensitivity and apparent cross-sectional area on CT as a function of CT beam energy using conventional CT techniques and virtual mono-energetic CT images generated from dual-energy acquisitions. Five

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c903dbd24e21479b395a6a75ab7924
https://doi.org/10.1007/s00330-014-3523-0

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Effects of Detector Thickness on Geometric Sensitivity and Event Positioning Errors in the Rectangular PET/X Scanner

Autor: Lawrence R. MacDonald, William C. J. Hunter, Paul E. Kinahan, Robert S. Miyaoka

Publikováno v: IEEE Transactions on Nuclear Science. 60:3242-3252

We used simulations to investigate the relationship between sensitivity and spatial resolution as a function of crystal thickness in a rectangular PET scanner intended for quantitative assessment of breast cancers. The system had two 20 × 15-cm2 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f530f970d9694628e4ea95be824a687b
https://doi.org/10.1109/tns.2013.2278841

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SCOUT: a fast Monte-Carlo modeling tool of scintillation camera output

Autor: Robert S. Miyaoka, Harrison H. Barrett, John P. Muzi, Thomas K. Lewellen, Lawrence R. MacDonald, Wendy McDougald, William C. J. Hunter

Publikováno v: Physics in Medicine and Biology. 58:3581-3598

We have developed a Monte-Carlo photon-tracking and readout simulator called SCOUT to study the stochastic behavior of signals output from a simplified rectangular scintillation-camera design. SCOUT models the salient processes affecting signal gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147518f184e2bed2e888a2368975f510
https://doi.org/10.1088/0031-9155/58/11/3581

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Evaluation of Cross-Calibrated 68Ge/68Ga Phantoms for Assessing PET/CT Measurement Bias in Oncology Imaging for Single- and Multicenter Trials

Autor: Hannah M. Linden, Robert K. Doot, Lawrence R. MacDonald, Wendy McDougald, Brian F. Elston, Keith C. Allberg, Darrin Byrd, Paul E. Kinahan

Publikováno v: Tomography; Volume 2; Issue 4; Pages: 353-360
Tomography
Volume 2
Issue 4
Pages 353-360
Tomography : a journal for imaging research

Quantitative PET imaging is an important tool for clinical trials evaluating the response of cancers to investigational therapies. The standardized uptake value, used as a quantitative imaging biomarker, is dependent on multiple parameters that may c

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Evaluation of event position reconstruction in monolithic crystals that are optically coupled

Autor: William C. J. Hunter, A. Del Guerra, Thomas K. Lewellen, Robert S. Miyaoka, Maria Giuseppina Bisogni, Paul E. Kinahan, Matteo Morrocchi, Lawrence R. MacDonald

A PET detector featuring a pseudo-monolithic crystal is being developed as a more cost-effective alternative to a full monolithic crystal PET detector. This work evaluates different methods to localize the scintillation events in quartered monolithic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a4a197c534555b1483fd5b34f41a69
https://europepmc.org/articles/PMC5132859/

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Positron emission mammography (PEM): Effect of activity concentration, object size, and object contrast on phantom lesion detection

Autor: David Haseley, James Rogers, Lawrence R. MacDonald, J. David Beatty, Carolyn L. Wang, Mary M. Kelly, Franklin Liu, Marna Eissa, Jay R. Parikh

Publikováno v: Medical Physics. 39:6499-6508

Purpose: To characterize the relationship between lesion detection sensitivity and injected activity as a function of lesion size and contrast on the PEM (positron emission mammography) Flex Solo II scanner using phantom experiments. Methods: Phantom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef90680aea61587a02a6b1dd97d19cb4
https://doi.org/10.1118/1.4754651

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