Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Lawrence R Kleinberg"'
Autor:
Lindsey Sloan, Rupashree Sen, Chunnan Liu, Michele Doucet, Lee Blosser, Lisa Katulis, David O. Kamson, Stuart Grossman, Matthias Holdhoff, Kristin J. Redmond, Harry Quon, Michael Lim, Charles Eberhart, Drew M. Pardoll, Chen Hu, Sudipto Ganguly, Lawrence R. Kleinberg
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThis is a prospective, rigorous inquiry into the systemic immune effects of standard adjuvant chemoradiotherapy, for WHO grade 4, glioblastoma. The purpose is to identify peripheral immunologic effects never yet reported in key immune pop
Externí odkaz:
https://doaj.org/article/742f40ed623045fca8f5d562b5aa68af
Autor:
Abinand C. Rejimon, Karthik K. Ramesh, Anuradha G. Trivedi, Vicki Huang, Eduard Schreibmann, Brent D. Weinberg, Lawrence R. Kleinberg, Hui-Kuo G. Shu, Hyunsuk Shim, Jeffrey J. Olson
Publikováno v:
Tomography, Vol 10, Iss 3, Pp 428-443 (2024)
Current diagnostic and therapeutic approaches for gliomas have limitations hindering survival outcomes. We propose spectroscopic magnetic resonance imaging as an adjunct to standard MRI to bridge these gaps. Spectroscopic MRI is a volumetric MRI tech
Externí odkaz:
https://doaj.org/article/96083e5061b6430facb2085954d78839
Autor:
Chi-Ming Chang, Karthik K. Ramesh, Vicki Huang, Saumya Gurbani, Lawrence R. Kleinberg, Brent D. Weinberg, Hyunsuk Shim, Hui-Kuo G. Shu
Publikováno v:
Tomography, Vol 9, Iss 3, Pp 942-954 (2023)
Histone deacetylase inhibitors (HDACis) are drugs that target the epigenetic state of cells by modifying the compaction of chromatin through effects on histone acetylation. Gliomas often harbor a mutation of isocitrate dehydrogenase (IDH) 1 or 2 that
Externí odkaz:
https://doaj.org/article/87774fd481ee4919b2a361c6eb91bdf0
Autor:
Anuradha G. Trivedi, Su Hyun Kim, Karthik K. Ramesh, Alexander S. Giuffrida, Brent D. Weinberg, Eric A. Mellon, Lawrence R. Kleinberg, Peter B. Barker, Hui Han, Hui-Kuo G. Shu, Hyunsuk Shim, Eduard Schreibmann
Publikováno v:
Tomography, Vol 9, Iss 3, Pp 1052-1061 (2023)
Accurate radiation therapy (RT) targeting is crucial for glioblastoma treatment but may be challenging using clinical imaging alone due to the infiltrative nature of glioblastomas. Precise targeting by whole-brain spectroscopic MRI, which maps tumor
Externí odkaz:
https://doaj.org/article/5e485b96372241f582bdefa0ac6356d7
Autor:
Lindsey Greenlund, Ryan Shanley, Kellen Mulford, Elizabeth C. Neil, Jessica Lawrence, Susan Arnold, Michael Olin, G. Elizabeth Pluhar, Andrew S. Venteicher, Clark C. Chen, Clara Ferreira, Margaret Reynolds, L. Chinsoo Cho, Christopher Wilke, B. Aika Shoo, Jianling Yuan, Kathryn Dusenbery, Lawrence R. Kleinberg, Stephanie A. Terezakis, Lindsey Sloan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTreatment for glioblastomas, aggressive and nearly uniformly fatal brain tumors, provide limited long-term success. Immunosuppression by myeloid cells in both the tumor microenvironment and systemic circulation are believed to contribute
Externí odkaz:
https://doaj.org/article/d1f68d365a3b44f692c9eb36b746cbf0
Autor:
Karthik K. Ramesh, Vicki Huang, Jeffrey Rosenthal, Eric A. Mellon, Mohammed Goryawala, Peter B. Barker, Saumya S. Gurbani, Anuradha G. Trivedi, Alexander S. Giuffrida, Eduard Schreibmann, Hui Han, Macarena de le Fuente, Erin M. Dunbar, Matthias Holdhoff, Lawrence R. Kleinberg, Hui-Kuo G. Shu, Hyunsuk Shim, Brent D. Weinberg
Publikováno v:
Tomography, Vol 9, Iss 1, Pp 362-374 (2023)
Glioblastoma (GBM) is a fatal disease, with poor prognosis exacerbated by difficulty in assessing tumor extent with imaging. Spectroscopic MRI (sMRI) is a non-contrast imaging technique measuring endogenous metabolite levels of the brain that can ser
Externí odkaz:
https://doaj.org/article/7e1bf384b7a148daa2140d6801c84cdc
Autor:
Jay-Jiguang Zhu, Samuel A. Goldlust, Lawrence R. Kleinberg, Jérôme Honnorat, Nancy Ann Oberheim Bush, Zvi Ram
Publikováno v:
Discover Oncology, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Purpose Tumor Treating Fields (TTFields) therapy, a noninvasive, anti-mitotic treatment modality, is approved for recurrent glioblastoma (rGBM) and newly diagnosed GBM based on phase III, EF-11 (NCT00379470) and EF-14 (NCT00916409) studies,
Externí odkaz:
https://doaj.org/article/6b86f4fa02bc4df287f3f7a35440e9c2
Autor:
Yilin Cao, MD, Valeria Fabre, MD, Roberta Anderson, DNP, Gregory Bova, Annette N. Souranis, RT(T), Valerie Briner, RT(T), Lawrence R. Kleinberg, MD, Sarah Han-Oh, PhD, Jean L. Wright, MD, Akila N. Viswanathan, MD, MPH
Publikováno v:
Advances in Radiation Oncology, Vol 8, Iss 2, Pp 101094- (2023)
Purpose: To develop the safest possible environment for treating urgent patients with COVID-19 requiring radiation, we describe the unique construction of negative air pressure computed tomography simulator and linear accelerator treatment vaults in
Externí odkaz:
https://doaj.org/article/0ae1fabbc5ae4f8a88054ce748b378bf
Autor:
Karen Xu, Karthik Ramesh, Vicki Huang, Saumya S. Gurbani, James Scott Cordova, Eduard Schreibmann, Brent D. Weinberg, Soma Sengupta, Alfredo D. Voloschin, Matthias Holdhoff, Peter B. Barker, Lawrence R. Kleinberg, Jeffrey J. Olson, Hui-Kuo G. Shu, Hyunsuk Shim
Publikováno v:
Tomography, Vol 8, Iss 2, Pp 688-700 (2022)
Glioblastoma (GBM) is highly aggressive and has a poor prognosis. Belinostat is a histone deacetylase inhibitor with blood–brain barrier permeability, anti-GBM activity, and the potential to enhance chemoradiation. The purpose of this clinical tria
Externí odkaz:
https://doaj.org/article/c5d64c1e66924dba9ace3ae3ee5433e3
Autor:
Jordina Rincon-Torroella, Megan Parker, Kelly Jiang, Josh Materi, Tej D. Azad, David Olayinka Kamson, Lawrence R. Kleinberg, Henry Brem, Chetan Bettegowda
Publikováno v:
Brain and Spine, Vol 3, Iss , Pp 102146- (2023)
Externí odkaz:
https://doaj.org/article/602710e7d27a4a7bbbfec829da03d2d2