Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lawrence R Gray"'
Autor:
Arpit Sharma, Lalita Oonthonpan, Ryan D Sheldon, Adam J Rauckhorst, Zhiyong Zhu, Sean C Tompkins, Kevin Cho, Wojciech J Grzesik, Lawrence R Gray, Diego A Scerbo, Alvin D Pewa, Emily M Cushing, Michael C Dyle, James E Cox, Chris Adams, Brandon S Davies, Richard K Shields, Andrew W Norris, Gary Patti, Leonid V Zingman, Eric B Taylor
Publikováno v:
eLife, Vol 8 (2019)
Metabolic cycles are a fundamental element of cellular and organismal function. Among the most critical in higher organisms is the Cori Cycle, the systemic cycling between lactate and glucose. Here, skeletal muscle-specific Mitochondrial Pyruvate Car
Externí odkaz:
https://doaj.org/article/13cd1adfdce945bdbb60969f1404d117
Autor:
Sean C. Tompkins, Ryan D. Sheldon, Adam J. Rauckhorst, Maria F. Noterman, Shane R. Solst, Jane L. Buchanan, Kranti A. Mapuskar, Alvin D. Pewa, Lawrence R. Gray, Lalita Oonthonpan, Arpit Sharma, Diego A. Scerbo, Adam J. Dupuy, Douglas R. Spitz, Eric B. Taylor
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2608-2619.e6 (2019)
Summary: Hepatocellular carcinoma (HCC) is a devastating cancer increasingly caused by non-alcoholic fatty liver disease (NAFLD). Disrupting the liver Mitochondrial Pyruvate Carrier (MPC) in mice attenuates NAFLD. Thus, we considered whether liver MP
Externí odkaz:
https://doaj.org/article/29feff27e7dd4d07ab314d89da837088
Autor:
Shannon Hitchcock, Alvin D. Pewa, Eric B. Taylor, Lawrence R. Gray, Jonas Maximilian Marx, Isabelle Robillard-Frayne, Thomas Cassier, Rose McGlauflin, Fariba Tayyari, Paul V. Taufalele, Lauren Haff, Lynn M. Teesch, Jamie Soto, Peter A. Crawford, Kathy Zimmerman, Trevor Funari, Jennifer L. Stueve, Robert M. Weiss, Christine Des Rosiers, E. Douglas Lewandowski, E. Dale Abel, Yuan Zhang, James E. Cox, Adam J. Rauckhorst, Kevin D. Lin, William J. Kutschke, Patrycja Puchalska, Jared Rutter, Jesse D. Cochran, Kevin M. Kato
Publikováno v:
Nature metabolism
In addition to fatty acids, glucose and lactate are important myocardial substrates under physiologic and stress conditions. They are metabolized to pyruvate, which enters mitochondria via the mitochondrial pyruvate carrier (MPC) for citric acid cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3413162a397848a5e3eb89491638c1b3
https://doi.org/10.1038/s42255-020-00288-1
https://doi.org/10.1038/s42255-020-00288-1
Autor:
Adam J. Rauckhorst, Xiaorong Fu, Katherine N. Gibson-Corley, Alvin D. Pewa, Ryan D. Sheldon, Eric B. Taylor, James E. Cox, Charlotte R. Feddersen, Shawn C. Burgess, Adam J. Dupuy, Lawrence R. Gray
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1468-1479 (2017)
Molecular Metabolism
Molecular Metabolism
Objective Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytosol into the mitochondrial m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80260421dd9726225c6f9a3cac3cf9fa
http://www.sciencedirect.com/science/article/pii/S2212877817306828
http://www.sciencedirect.com/science/article/pii/S2212877817306828
Autor:
Eric B. Taylor, Kevin Cho, Emily M. Cushing, Christopher M. Adams, Brandon S.J. Davies, Gary J. Patti, James E. Cox, Diego A Scerbo, Zhiyong Zhu, Lawrence R. Gray, Adam J. Rauckhorst, Wojciech J. Grzesik, Richard K. Shields, Michael C. Dyle, Arpit Sharma, Lalita Oonthonpan, Sean C. Tompkins, Andrew W. Norris, Leonid V. Zingman, Ryan D. Sheldon, Alvin D. Pewa
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Metabolic cycles are a fundamental element of cellular and organismal function. Among the most critical in higher organisms is the Cori Cycle, the systemic cycling between lactate and glucose. Here, skeletal muscle-specific Mitochondrial Pyruvate Car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2177ec19b7bfb3092c484e6534c92ae6
https://doi.org/10.7554/elife.45873
https://doi.org/10.7554/elife.45873
Publikováno v:
JCI Insight. 4
The Mitochondrial Pyruvate Carrier (MPC) occupies a central metabolic node by transporting cytosolic pyruvate into the mitochondrial matrix and linking glycolysis with mitochondrial metabolism. Two reported human MPC1 mutations cause developmental ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a15d8dba31b1e68d2dd6f643c35443
https://doi.org/10.1172/jci.insight.126132
https://doi.org/10.1172/jci.insight.126132
Autor:
Lawrence R. Gray, Michael C. Dyle, Kevin Cho, Andrew W. Norris, Arpit Sharma, Alvin D. Pewa, Eric B. Taylor, Emily M. Cushing, Christopher M. Adams, Adam J. Rauckhorst, Leonid V. Zingman, Zhiyong Zhu, Sean C. Tompkins, Lalita Oonthonpan, Richard K. Shields, Ryan D. Sheldon, Wojciech J. Grzesik, Diego A Scerbo, Brandon S.J. Davies, James E. Cox, Gary J. Patti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6fd7c09a9ed6c3c31f52227e1340afa
https://doi.org/10.7554/elife.45873.027
https://doi.org/10.7554/elife.45873.027
Publikováno v:
Journal of Biological Chemistry. 291:7409-7417
The discovery that the MPC1 and MPC2 genes encode the protein components of the mitochondrial pyruvate carrier (MPC) has invigorated studies of mitochondrial pyruvate transport and its regulation in normal and disease states. Indeed, recent reports h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186f368ac2416bebe6f87b1c4589f6e7
https://doi.org/10.1074/jbc.m115.711663
https://doi.org/10.1074/jbc.m115.711663
Autor:
Isabelle Robillard-Frayne, James E. Cox, William J. Kutschke, E. Dale Abel, Lauren Haff, Alvin D. Pewa, Eric B. Taylor, Peter A. Crawford, Jennifer L. Stueve, Christine Des Rosiers, E. Douglas Lewandowski, Kevin D. Lin, Trevor Funari, Shannon Hitchcock, Yuan Zhang, Kathy Zimmerman, Paul V. Taufalele, Thomas Cassier, Lawrence R. Gray, Rose McGlauflin, Jonas Maximilian Marx, Robert M. Weiss, Patrycja Puchalska, Jared Rutter, Jesse D. Cochran, Kevin M. Kato, Fariba Tayyari, Adam J. Rauckhorst, Jamie Soto, Lynn M. Teesch
Publikováno v:
Nature Metabolism. 2:1498-1498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03b54607500db41817f046f2a2540011
https://doi.org/10.1038/s42255-020-00322-2
https://doi.org/10.1038/s42255-020-00322-2
Autor:
Erin E. Lane, Lalita Oonthonpan, James E. Cox, Shawn C. Burgess, Jared Rutter, Ashley Dohlman, Matthew J. Potthoff, Lawrence R. Gray, Sean C. Tompkins, Adam J. Rauckhorst, Jianxin Xie, Arpit Sharma, Ren Miao, Kathryn S. Brown, Andrew W. Norris, Alvin D. Pewa, Eric B. Taylor, Diana Zepeda-Orozco, Xiaorong Fu, Mst Rasheda Sultana
Publikováno v:
Cell Metabolism. 22(4):669-681
SummaryGluconeogenesis is critical for maintenance of euglycemia during fasting. Elevated gluconeogenesis during type 2 diabetes (T2D) contributes to chronic hyperglycemia. Pyruvate is a major gluconeogenic substrate and requires import into the mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8539d20edf7ac7da737f89bf45f6aa62