Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Lawrence O Whiteley"'
Publikováno v:
The Journal of toxicological sciences. 46(2)
The number of gene therapies in development continues to increase, as they represent a novel method to treat, and potentially cure, many diseases. Gene therapies can be conducted with an in vivo or ex vivo approach, to cause gene augmentation, gene s
Publikováno v:
Nucleic acid therapeutics. 26(2)
Development of locked nucleic acid (LNA) gapmers, antisense oligonucleotides used for efficient inhibition of target RNA expression, is limited by nontarget-mediated hepatotoxicity. Increased binding of hepatocellular proteins to toxic LNA gapmers ma