Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lawrence MacPherson"'
Autor:
Stuart L. Schreiber, Michael Foley, Andrew Germain, Willmen Youngsaye, Timothy A. Lewis, Lawrence MacPherson, Michelle Palmer, Marek M. Nagiec, Christina Scherer, Han-Je Kim, Partha P. Nag, Michel Weïwer, BenjaminZ. Stanton, Chris Dockendorff, Melissa Bennion, Amal Ting, Jose Perez, Sara J. Buhrlage, Linlong Xue
Publikováno v:
ACS Medicinal Chemistry Letters
Macrocyclic Hedgehog (Hh) pathway inhibitors have been discovered with improved potency and maximal inhibition relative to the previously reported macrocycle robotnikinin. Analogues were prepared using a modular and efficient build-couple-pair (BCP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc04990686166e13543e4d28b5f1f68
https://doi.org/10.1021/ml300172p
https://doi.org/10.1021/ml300172p
Autor:
Kevin J. Embrey, Julie Demeritt, Joanna Bryant, Beth Andrews, George B. Mullen, Ning Gao, Lawrence Macpherson, James T. Loch, Ken Hull, Bryan Prince, Brian Sherer, Alok Singh, P. Ann Boriack-Sjodin, Sheila Irene Hauck, Oluyinka Green, Ann E. Eakin, Haihong Ni, Ruth Illingworth, Dave Timms, Maria Uria-Nickelsen, Grant K. Walkup, Neil James Hales, Alexander L. Breeze, April E. Blodgett, Shanta Bist
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:1240-1246
DNA gyrase is an essential enzyme in bacteria, and its inhibition results in the disruption of DNA synthesis and, subsequently, cell death. The pyrrolamides are a novel class of antibacterial agents targeting DNA gyrase. These compounds were identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b8b08a77f0d6262fe9dd591b0c4d6a
https://doi.org/10.1128/aac.05485-11
https://doi.org/10.1128/aac.05485-11
Autor:
Michelle Palmer, Sivaraman Dandapani, Cristina Galan-Rodriguez, Leigh C. Carmody, Chris Dockendorff, Ana Rodriguez, Andrew R. Germain, Lawrence MacPherson, Stephen Johnston, Benito Munoz, Joshua A. Bittker, Stuart L. Schreiber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7197-7200
We report the outcome of a high-throughput small-molecule screen to identify novel, nontoxic, inhibitors of Trypansoma cruzi, as potential starting points for therapeutics to treat for both the acute and chronic stages of Chagas disease. Two compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703bc96e5374ce40d59f73a02506b049
https://doi.org/10.1016/j.bmcl.2011.09.057
https://doi.org/10.1016/j.bmcl.2011.09.057
Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor
Autor:
Chris Dockendorff, Lynn VerPlank, Joseph Negri, Daniel A. Smith, Robert Flaumenhaft, Stuart L. Schreiber, James R. Dilks, Louisa Dowal, Michelle Palmer, Lawrence MacPherson, Omozuanvbo Aisiku, Susanna F. Gunnink
Publikováno v:
ACS Medicinal Chemistry Letters
A high-throughput screen of the NIH-MLSMR compound collection, along with a series of secondary assays to identify potential targets of hit compounds, previously identified a 1,3-diaminobenzene scaffold that targets protease-activated receptor 1 (PAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34633bfdc69e2fd9dd2ac2b7e91723e8
https://pubmed.ncbi.nlm.nih.gov/22408714
https://pubmed.ncbi.nlm.nih.gov/22408714
Autor:
Michelle Palmer, Kenichi Shimada, Sivaraman Dandapani, Brent R. Stockwell, Timothy A. Lewis, Benito Munoz, Lawrence MacPherson, Michel Weïwer, Joshua A. Bittker, Wan Seok Yang, Stuart L. Schreiber
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(4)
Synthetic lethal screening is a chemical biology approach to identify small molecules that selectively kill oncogene-expressing cell lines with the goal of identifying pathways that provide specific targets against cancer cells. We performed a high-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0535fe1ddf5ff753aa66a4aae13789
https://pubmed.ncbi.nlm.nih.gov/22297109
https://pubmed.ncbi.nlm.nih.gov/22297109
Autor:
Michelle Palmer, Stuart L. Schreiber, Benjamin Vincent, Barbara Morgan, Benito Munoz, Sara J. Buhrlage, Sivaraman Dandapani, Willmen Youngsaye, Luke Whitesell, Cathy L Hartland, Joshua A. Bittker, Susan Lindquist, Stephen Johnston, Lawrence MacPherson
Publikováno v:
PMC
The effectiveness of the potent antifungal drug fluconazole is being compromised by the rise of drug-resistant fungal pathogens. While inhibition of Hsp90 or calcineurin can reverse drug resistance in Candida, such inhibitors also impair the homologo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89eb5bf088a3aee42cfff8a69d15d02d
http://hdl.handle.net/1721.1/99136
http://hdl.handle.net/1721.1/99136
Autor:
Alexander Satz, Lawrence Macpherson, Gregory S. Basarab, Bolin Geng, Ekundayo Osimboni, Pamela Hill, Charles J. Eyermann, Janelle Comita-Prevoir, Madhusudhan Reddy Gowravaram, George B. Mullen, Tomas Lundqvist, Marshall Morningstar, Andrew Kiely, James T. Loch
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
An SAR study of an HTS screening hit generated a series of pyridodiazepine amines as potent inhibitors of Helicobacter pylori glutamate racemase (MurI) showing highly selective anti-H. pylori activity, marked improved solubility, and reduced plasma p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569ca10e683562576800e405bb8042c7
https://pubmed.ncbi.nlm.nih.gov/19097892
https://pubmed.ncbi.nlm.nih.gov/19097892
Autor:
Jason Burbank, Lynn VerPlank, James R. Dilks, Price S. Blair, Robert Gould, Albert Mairuhu, Michelle Palmer, Robert Flaumenhaft, Lawrence MacPherson, Gil Walzer, Tyler Aldredge, Chris Dockendorff, Joseph Negri
Publikováno v:
Blood. 114:4009-4009
Abstract 4009 Poster Board III-945 Platelets are anucleate cells that are not amenable to traditional forward genetic analysis. In collaboration with the Broad Institute Probe Development Center, we have performed a chemical genetic analysis of plate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53c3e59b1c7cedbedf852701d6f7ced3
https://doi.org/10.1182/blood.v114.22.4009.4009
https://doi.org/10.1182/blood.v114.22.4009.4009